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B5DEH2

- ERLN2_RAT

UniProt

B5DEH2 - ERLN2_RAT

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Protein
Erlin-2
Gene
Erlin2, Spfh2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway By similarity.

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Erlin-2
Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Short name:
SPFH domain-containing protein 2
Gene namesi
Name:Erlin2
Synonyms:Spfh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1309010. Erlin2.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity
Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33Cytoplasmic Reviewed prediction
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Topological domaini25 – 339315Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
  4. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Erlin-2
PRO_0000371230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB5DEH2.
PRIDEiB5DEH2.

PTM databases

PhosphoSiteiB5DEH2.

Expressioni

Gene expression databases

GenevestigatoriB5DEH2.

Interactioni

Subunit structurei

Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170 By similarity. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination By similarity.

Protein-protein interaction databases

BioGridi253334. 2 interactions.
IntActiB5DEH2. 2 interactions.
STRINGi10116.ENSRNOP00000018973.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 309133Interaction with ERLIN1 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the band 7/mec-2 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307809.
GeneTreeiENSGT00390000014666.
HOGENOMiHOG000251613.
OMAiNMFVDSA.
OrthoDBiEOG7Z69D1.
PhylomeDBiB5DEH2.
TreeFamiTF313059.

Family and domain databases

InterProiIPR001107. Band_7.
[Graphical view]
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DEH2-1 [UniParc]FASTAAdd to Basket

« Hide

MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH    50
LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPHAV 100
YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL 150
ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ 200
KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK KISEIEDAAF 250
LAREKAKADA ECYTALKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD 300
IPNMFMDSAG GLGKQSEGLS DKLGFGLEDE PLETATKDN 339
Length:339
Mass (Da):37,710
Last modified:October 14, 2008 - v1
Checksum:iA777F11C4B1A47D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH473970 Genomic DNA. Translation: EDM09088.1.
BC168668 mRNA. Translation: AAI68668.1.
RefSeqiNP_001099558.1. NM_001106088.2.
UniGeneiRn.12619.

Genome annotation databases

EnsembliENSRNOT00000018973; ENSRNOP00000018973; ENSRNOG00000013763.
GeneIDi290823.
KEGGirno:290823.
UCSCiRGD:1309010. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH473970 Genomic DNA. Translation: EDM09088.1 .
BC168668 mRNA. Translation: AAI68668.1 .
RefSeqi NP_001099558.1. NM_001106088.2.
UniGenei Rn.12619.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 253334. 2 interactions.
IntActi B5DEH2. 2 interactions.
STRINGi 10116.ENSRNOP00000018973.

PTM databases

PhosphoSitei B5DEH2.

Proteomic databases

PaxDbi B5DEH2.
PRIDEi B5DEH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018973 ; ENSRNOP00000018973 ; ENSRNOG00000013763 .
GeneIDi 290823.
KEGGi rno:290823.
UCSCi RGD:1309010. rat.

Organism-specific databases

CTDi 11160.
RGDi 1309010. Erlin2.

Phylogenomic databases

eggNOGi NOG307809.
GeneTreei ENSGT00390000014666.
HOGENOMi HOG000251613.
OMAi NMFVDSA.
OrthoDBi EOG7Z69D1.
PhylomeDBi B5DEH2.
TreeFami TF313059.

Miscellaneous databases

NextBioi 631715.
PROi B5DEH2.

Gene expression databases

Genevestigatori B5DEH2.

Family and domain databases

InterProi IPR001107. Band_7.
[Graphical view ]
Pfami PF01145. Band_7. 1 hit.
[Graphical view ]
SMARTi SM00244. PHB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Maurya D.K., Bhargava P.
    Submitted (MAR-2009) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiERLN2_RAT
AccessioniPrimary (citable) accession number: B5DEH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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