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B5DEH2

- ERLN2_RAT

UniProt

B5DEH2 - ERLN2_RAT

Protein

Erlin-2

Gene

Erlin2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway By similarity.By similarity

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Erlin-2By similarity
    Alternative name(s):
    Endoplasmic reticulum lipid raft-associated protein 2ImportedBy similarity
    Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2By similarity
    Short name:
    SPFH domain-containing protein 2ImportedBy similarity
    Gene namesi
    Name:Erlin2Imported
    Synonyms:Spfh2By similarity
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi1309010. Erlin2.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl
    4. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Erlin-2PRO_0000371230Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiB5DEH2.
    PRIDEiB5DEH2.

    PTM databases

    PhosphoSiteiB5DEH2.

    Expressioni

    Gene expression databases

    GenevestigatoriB5DEH2.

    Interactioni

    Subunit structurei

    Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170 By similarity. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination By similarity.By similarity

    Protein-protein interaction databases

    BioGridi253334. 2 interactions.
    IntActiB5DEH2. 2 interactions.
    STRINGi10116.ENSRNOP00000018973.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33CytoplasmicSequence Analysis
    Topological domaini25 – 339315ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni177 – 309133Interaction with ERLIN1By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the band 7/mec-2 family.Sequence Analysis

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307809.
    GeneTreeiENSGT00390000014666.
    HOGENOMiHOG000251613.
    OMAiNMFVDSA.
    OrthoDBiEOG7Z69D1.
    PhylomeDBiB5DEH2.
    TreeFamiTF313059.

    Family and domain databases

    InterProiIPR001107. Band_7.
    [Graphical view]
    PfamiPF01145. Band_7. 1 hit.
    [Graphical view]
    SMARTiSM00244. PHB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5DEH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH    50
    LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPHAV 100
    YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL 150
    ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ 200
    KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK KISEIEDAAF 250
    LAREKAKADA ECYTALKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD 300
    IPNMFMDSAG GLGKQSEGLS DKLGFGLEDE PLETATKDN 339
    Length:339
    Mass (Da):37,710
    Last modified:October 14, 2008 - v1
    Checksum:iA777F11C4B1A47D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473970 Genomic DNA. Translation: EDM09088.1.
    BC168668 mRNA. Translation: AAI68668.1.
    RefSeqiNP_001099558.1. NM_001106088.2.
    UniGeneiRn.12619.

    Genome annotation databases

    EnsembliENSRNOT00000018973; ENSRNOP00000018973; ENSRNOG00000013763.
    GeneIDi290823.
    KEGGirno:290823.
    UCSCiRGD:1309010. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473970 Genomic DNA. Translation: EDM09088.1 .
    BC168668 mRNA. Translation: AAI68668.1 .
    RefSeqi NP_001099558.1. NM_001106088.2.
    UniGenei Rn.12619.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 253334. 2 interactions.
    IntActi B5DEH2. 2 interactions.
    STRINGi 10116.ENSRNOP00000018973.

    PTM databases

    PhosphoSitei B5DEH2.

    Proteomic databases

    PaxDbi B5DEH2.
    PRIDEi B5DEH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018973 ; ENSRNOP00000018973 ; ENSRNOG00000013763 .
    GeneIDi 290823.
    KEGGi rno:290823.
    UCSCi RGD:1309010. rat.

    Organism-specific databases

    CTDi 11160.
    RGDi 1309010. Erlin2.

    Phylogenomic databases

    eggNOGi NOG307809.
    GeneTreei ENSGT00390000014666.
    HOGENOMi HOG000251613.
    OMAi NMFVDSA.
    OrthoDBi EOG7Z69D1.
    PhylomeDBi B5DEH2.
    TreeFami TF313059.

    Miscellaneous databases

    NextBioi 631715.
    PROi B5DEH2.

    Gene expression databases

    Genevestigatori B5DEH2.

    Family and domain databases

    InterProi IPR001107. Band_7.
    [Graphical view ]
    Pfami PF01145. Band_7. 1 hit.
    [Graphical view ]
    SMARTi SM00244. PHB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ProstateImported.
    3. Maurya D.K., Bhargava P.
      Submitted (MAR-2009) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiERLN2_RAT
    AccessioniPrimary (citable) accession number: B5DEH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3