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B5DEH2

- ERLN2_RAT

UniProt

B5DEH2 - ERLN2_RAT

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Protein

Erlin-2

Gene

Erlin2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (By similarity).By similarity

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Erlin-2By similarity
Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2ImportedBy similarity
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2By similarity
Short name:
SPFH domain-containing protein 2ImportedBy similarity
Gene namesi
Name:Erlin2Imported
Synonyms:Spfh2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1309010. Erlin2.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence Analysis
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Topological domaini25 – 339315ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Erlin-2PRO_0000371230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB5DEH2.
PRIDEiB5DEH2.

PTM databases

PhosphoSiteiB5DEH2.

Expressioni

Gene expression databases

GenevestigatoriB5DEH2.

Interactioni

Subunit structurei

Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170 (By similarity). Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination (By similarity).By similarity

Protein-protein interaction databases

BioGridi253334. 6 interactions.
IntActiB5DEH2. 2 interactions.
STRINGi10116.ENSRNOP00000018973.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 309133Interaction with ERLIN1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Sequence Analysis

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307809.
GeneTreeiENSGT00390000014666.
HOGENOMiHOG000251613.
InParanoidiB5DEH2.
OMAiNMFVDSA.
OrthoDBiEOG7Z69D1.
PhylomeDBiB5DEH2.
TreeFamiTF313059.

Family and domain databases

InterProiIPR001107. Band_7.
[Graphical view]
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DEH2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH
60 70 80 90 100
LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPHAV
110 120 130 140 150
YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL
160 170 180 190 200
ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ
210 220 230 240 250
KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK KISEIEDAAF
260 270 280 290 300
LAREKAKADA ECYTALKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD
310 320 330
IPNMFMDSAG GLGKQSEGLS DKLGFGLEDE PLETATKDN
Length:339
Mass (Da):37,710
Last modified:October 14, 2008 - v1
Checksum:iA777F11C4B1A47D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473970 Genomic DNA. Translation: EDM09088.1.
BC168668 mRNA. Translation: AAI68668.1.
RefSeqiNP_001099558.1. NM_001106088.2.
XP_008769545.1. XM_008771323.1.
XP_008769546.1. XM_008771324.1.
UniGeneiRn.12619.

Genome annotation databases

EnsembliENSRNOT00000018973; ENSRNOP00000018973; ENSRNOG00000013763.
GeneIDi290823.
KEGGirno:290823.
UCSCiRGD:1309010. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473970 Genomic DNA. Translation: EDM09088.1 .
BC168668 mRNA. Translation: AAI68668.1 .
RefSeqi NP_001099558.1. NM_001106088.2.
XP_008769545.1. XM_008771323.1.
XP_008769546.1. XM_008771324.1.
UniGenei Rn.12619.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 253334. 6 interactions.
IntActi B5DEH2. 2 interactions.
STRINGi 10116.ENSRNOP00000018973.

PTM databases

PhosphoSitei B5DEH2.

Proteomic databases

PaxDbi B5DEH2.
PRIDEi B5DEH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018973 ; ENSRNOP00000018973 ; ENSRNOG00000013763 .
GeneIDi 290823.
KEGGi rno:290823.
UCSCi RGD:1309010. rat.

Organism-specific databases

CTDi 11160.
RGDi 1309010. Erlin2.

Phylogenomic databases

eggNOGi NOG307809.
GeneTreei ENSGT00390000014666.
HOGENOMi HOG000251613.
InParanoidi B5DEH2.
OMAi NMFVDSA.
OrthoDBi EOG7Z69D1.
PhylomeDBi B5DEH2.
TreeFami TF313059.

Miscellaneous databases

NextBioi 631715.
PROi B5DEH2.

Gene expression databases

Genevestigatori B5DEH2.

Family and domain databases

InterProi IPR001107. Band_7.
[Graphical view ]
Pfami PF01145. Band_7. 1 hit.
[Graphical view ]
SMARTi SM00244. PHB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ProstateImported.
  3. Maurya D.K., Bhargava P.
    Submitted (MAR-2009) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiERLN2_RAT
AccessioniPrimary (citable) accession number: B5DEH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3