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B5DEH2 (ERLN2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Erlin-2
Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Short name=SPFH domain-containing protein 2
Gene names
Name:Erlin2
Synonyms:Spfh2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway By similarity.

Subunit structure

Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170 By similarity. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity. Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane By similarity. UniProtKB O94905

Sequence similarities

Belongs to the band 7/mec-2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Erlin-2
PRO_0000371230

Regions

Topological domain1 – 33Cytoplasmic Potential
Transmembrane4 – 2421Helical; Potential
Topological domain25 – 339315Extracellular Potential
Region177 – 309133Interaction with ERLIN1 By similarity

Amino acid modifications

Glycosylation1061N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B5DEH2 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: A777F11C4B1A47D7

FASTA33937,710
        10         20         30         40         50         60 
MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH LMLPFITSYK 

        70         80         90        100        110        120 
SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPHAV YDIVKNYTAD YDKALIFNKI 

       130        140        150        160        170        180 
HHELNQFCSV HTLQEVYIEL FDQIDENLKL ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR 

       190        200        210        220        230        240 
RNYELMESEK TKLLIAAQKQ KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK 

       250        260        270        280        290        300 
KISEIEDAAF LAREKAKADA ECYTALKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD 

       310        320        330 
IPNMFMDSAG GLGKQSEGLS DKLGFGLEDE PLETATKDN 

« Hide

References

« Hide 'large scale' references
[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[3]Maurya D.K., Bhargava P.
Submitted (MAR-2009) to UniProtKB
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH473970 Genomic DNA. Translation: EDM09088.1.
BC168668 mRNA. Translation: AAI68668.1.
RefSeqNP_001099558.1. NM_001106088.2.
UniGeneRn.12619.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid253334. 2 interactions.
IntActB5DEH2. 2 interactions.
STRING10116.ENSRNOP00000018973.

PTM databases

PhosphoSiteB5DEH2.

Proteomic databases

PaxDbB5DEH2.
PRIDEB5DEH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018973; ENSRNOP00000018973; ENSRNOG00000013763.
GeneID290823.
KEGGrno:290823.
UCSCRGD:1309010. rat.

Organism-specific databases

CTD11160.
RGD1309010. Erlin2.

Phylogenomic databases

eggNOGNOG307809.
GeneTreeENSGT00390000014666.
HOGENOMHOG000251613.
OMANMFVDSA.
OrthoDBEOG7Z69D1.
PhylomeDBB5DEH2.
TreeFamTF313059.

Gene expression databases

GenevestigatorB5DEH2.

Family and domain databases

InterProIPR001107. Band_7.
[Graphical view]
PfamPF01145. Band_7. 1 hit.
[Graphical view]
SMARTSM00244. PHB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio631715.
PROB5DEH2.

Entry information

Entry nameERLN2_RAT
AccessionPrimary (citable) accession number: B5DEH2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families