B5DEH2 (ERLN2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Erlin-2

Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Short name=SPFH domain-containing protein 2

Gene names

Name:	Erlin2
Synonyms:	Spfh2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway By similarity.
Subunit structure	Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170 By similarity. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity. Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane By similarity. UniProtKB O94905
Sequence similarities	Belongs to the band 7/mec-2 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER-associated protein catabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Erlin-2		PRO_0000371230
Regions
	Topological domain	1 – 3	3	Cytoplasmic Potential
	Transmembrane	4 – 24	21	Helical; Potential
	Topological domain	25 – 339	315	Extracellular Potential
	Region	177 – 309	133	Interaction with ERLIN1 By similarity
Amino acid modifications
	Glycosylation	106	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	B5DEH2 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: A777F11C4B1A47D7	FASTA	339	37,710
	10 20 30 40 50 60 MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH LMLPFITSYK 70 80 90 100 110 120 SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPHAV YDIVKNYTAD YDKALIFNKI 130 140 150 160 170 180 HHELNQFCSV HTLQEVYIEL FDQIDENLKL ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR 190 200 210 220 230 240 RNYELMESEK TKLLIAAQKQ KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK 250 260 270 280 290 300 KISEIEDAAF LAREKAKADA ECYTALKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD 310 320 330 IPNMFMDSAG GLGKQSEGLS DKLGFGLEDE PLETATKDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[3]	Maurya D.K., Bhargava P. Submitted (MAR-2009) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH473970 Genomic DNA. Translation: EDM09088.1. BC168668 mRNA. Translation: AAI68668.1.
IPI	IPI00201494.
RefSeq	NP_001099558.1. NM_001106088.2.
UniGene	Rn.12619.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000018973.
PTM databases
PhosphoSite	B5DEH2.
Proteomic databases
PaxDb	B5DEH2.
PRIDE	B5DEH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000018973; ENSRNOP00000018973; ENSRNOG00000013763.
GeneID	290823.
KEGG	rno:290823.
UCSC	RGD:1309010. rat.
Organism-specific databases
CTD	11160.
RGD	1309010. Erlin2.
Phylogenomic databases
eggNOG	NOG307809.
GeneTree	ENSGT00390000014666.
HOGENOM	HOG000251613.
OMA	AECYTAL.
OrthoDB	EOG4ZPDVS.
Gene expression databases
Genevestigator	B5DEH2.
Family and domain databases
InterPro	IPR001107. Band_7. [Graphical view]
Pfam	PF01145. Band_7. 1 hit. [Graphical view]
SMART	SM00244. PHB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	631715.

Entry information

Entry name

ERLN2_RAT

Accession

Primary (citable) accession number: B5DEH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program