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B5DEG1

- B5DEG1_RAT

UniProt

B5DEG1 - B5DEG1_RAT

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Protein
Submitted name:

Protein Itga8

Gene
Itga8, RGD1564327
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. brain development Source: RGD
  2. cell adhesion Source: UniProtKB-KW
  3. cell projection organization Source: Ensembl
  4. establishment of protein localization Source: Ensembl
  5. extracellular matrix organization Source: Ensembl
  6. inner ear morphogenesis Source: Ensembl
  7. integrin-mediated signaling pathway Source: UniProtKB-KW
  8. memory Source: Ensembl
  9. metanephros development Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
  11. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  12. smooth muscle tissue development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotations, ReceptorUniRule annotationSAAS annotations

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_198592. Molecules associated with elastic fibres.
REACT_198757. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Itga8Imported
Submitted name:
RGD1564327 proteinImported
Gene namesi
Name:Itga8Imported
Synonyms:RGD1564327Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi621634. Itga8.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. dendritic spine membrane Source: RGD
  3. integrin complex Source: InterPro
  4. perikaryon Source: RGD
  5. postsynaptic density Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriB5DEG1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022713.

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotation
Contains FG-GAP repeats.SAAS annotations

Keywords - Domaini

RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00750000117267.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
KOiK06584.
OMAiCRQIPFD.
OrthoDBiEOG7HQN77.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 6 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DEG1-1 [UniParc]FASTAAdd to Basket

« Hide

MSARTHRGPP ENWAPPFACL CCVSAVLGML WSPVSLAFNL DVDKLTVYSG     50
PEGSYFGYSL DFYIPDARTA SVLVGAPKAN TSQPDIVEGG AVYYCPWPAE 100
RSAQCKQIPF DTTNNRKIRV NGTKEPIEFK SNQWFGATVR AHKGKVVACA 150
PLYHWRTLKP NPAKDPVGTC YVAIQNFSAY AEHSPCRNSN VDPEGQGYCQ 200
AGFSLDFYKN GDLIVGGPGS FYWQGQVITV SVADIIANYS FKDILRKLAA 250
EKQTDVAPAS YDDSYLGYSV AAGEFTGDSL QELVAGIPRG AQNFGYVSII 300
NSTDMTFIQN FTGEQMASYF GYTVVVSDVN NDGMDDILVG APLFMEREFE 350
SNPREVGQVY LYLQVSALLF QDPQVLTGTE TFGRFGSSVA HLGDLNQDGY 400
NDIAIGVPFA GKDQRGKVLI YNGNARGLHS KPSQVLQGIW GSQTIPSGFG 450
FSLRGDADID KNDYPDLLVG AFGEGKVAVY RARPVVTVDA QLLLHPMIIN 500
LENKTCQIPE FPTPVACFSL RVCASIAGQS ISNTVALMAE VQLDFLKQKG 550
AIKRTLFLHN HQSHLIFPFV MRQQKSLHCQ DFMVYLRDET EFRDKLSPIN 600
VSLNYSLDDS TFEDGLEVKP ILNHYRENVV TEQAHILVDC GEDNLCVPDL 650
RLSARPDKQE IIIGDENHLM LIINARNEGE GAYEAELFVM IPEEADYVGI 700
ERNNKGLRLL SCEYKMENVT RMVVCDLGNP MVTGTNFSLG LRFAVPRLEK 750
TNMSINFDLQ IRSSNKDNPD SNFVSVQINV TAVAQVEIRG VSHPPQIVLP 800
IHNWEPAEEP HKEEEVGPLV EHIYELHNIG PSTISDSILE VGWPFSAREE 850
FLLYVFHLQT LGPLQCQTNP EINPQDIKPA ASPEDTPELS AFLRNATIPH 900
LVRKRDVPVV QPHRQSPAKI LNCTNIDCLQ ISCAVGRLGG GESAVLKVRS 950
RLWAHTFLQR KNDPYALASL VSFEVKKIPY KEQPAKLPAG STAIKTSVIW 1000
ATPNVSFSIP LWVIILAILL GLLVLAILTL ALWKCGFFDR ARPPQDEMTD 1050
REQLTSDKTP EA 1062
Length:1,062
Mass (Da):117,575
Last modified:October 14, 2008 - v1
Checksum:i24F33BC97E4B670C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06093120 Genomic DNA. No translation available.
AABR06093121 Genomic DNA. No translation available.
AABR06093122 Genomic DNA. No translation available.
AABR06093123 Genomic DNA. No translation available.
AABR06093124 Genomic DNA. No translation available.
AABR06093125 Genomic DNA. No translation available.
AABR06093126 Genomic DNA. No translation available.
AABR06093127 Genomic DNA. No translation available.
AABR06093128 Genomic DNA. No translation available.
AABR06093129 Genomic DNA. No translation available.
AABR06093130 Genomic DNA. No translation available.
AABR06093131 Genomic DNA. No translation available.
AABR06093132 Genomic DNA. No translation available.
AABR06093133 Genomic DNA. No translation available.
AABR06093134 Genomic DNA. No translation available.
AABR06093135 Genomic DNA. No translation available.
AABR06093136 Genomic DNA. No translation available.
AABR06093137 Genomic DNA. No translation available.
BC168655 mRNA. Translation: AAI68655.1.
RefSeqiNP_001167443.1. NM_001173972.1.
UniGeneiRn.69726.

Genome annotation databases

EnsembliENSRNOT00000022711; ENSRNOP00000022713; ENSRNOG00000016538.
GeneIDi364786.
KEGGirno:364786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06093120 Genomic DNA. No translation available.
AABR06093121 Genomic DNA. No translation available.
AABR06093122 Genomic DNA. No translation available.
AABR06093123 Genomic DNA. No translation available.
AABR06093124 Genomic DNA. No translation available.
AABR06093125 Genomic DNA. No translation available.
AABR06093126 Genomic DNA. No translation available.
AABR06093127 Genomic DNA. No translation available.
AABR06093128 Genomic DNA. No translation available.
AABR06093129 Genomic DNA. No translation available.
AABR06093130 Genomic DNA. No translation available.
AABR06093131 Genomic DNA. No translation available.
AABR06093132 Genomic DNA. No translation available.
AABR06093133 Genomic DNA. No translation available.
AABR06093134 Genomic DNA. No translation available.
AABR06093135 Genomic DNA. No translation available.
AABR06093136 Genomic DNA. No translation available.
AABR06093137 Genomic DNA. No translation available.
BC168655 mRNA. Translation: AAI68655.1 .
RefSeqi NP_001167443.1. NM_001173972.1.
UniGenei Rn.69726.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000022713.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022711 ; ENSRNOP00000022713 ; ENSRNOG00000016538 .
GeneIDi 364786.
KEGGi rno:364786.

Organism-specific databases

CTDi 8516.
RGDi 621634. Itga8.

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00750000117267.
HOGENOMi HOG000231603.
HOVERGENi HBG006186.
KOi K06584.
OMAi CRQIPFD.
OrthoDBi EOG7HQN77.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_198592. Molecules associated with elastic fibres.
REACT_198757. ECM proteoglycans.

Miscellaneous databases

NextBioi 686038.
PROi B5DEG1.

Gene expression databases

Genevestigatori B5DEG1.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 6 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiB5DEG1_RAT
AccessioniPrimary (citable) accession number: B5DEG1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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