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B5DEG1

- B5DEG1_RAT

UniProt

B5DEG1 - B5DEG1_RAT

Protein
Submitted name:

Protein Itga8

Gene

Itga8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. brain development Source: RGD
    2. cell adhesion Source: UniProtKB-KW
    3. cell projection organization Source: Ensembl
    4. establishment of protein localization Source: Ensembl
    5. extracellular matrix organization Source: Ensembl
    6. inner ear morphogenesis Source: Ensembl
    7. integrin-mediated signaling pathway Source: UniProtKB-KW
    8. memory Source: Ensembl
    9. metanephros development Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
    11. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    12. smooth muscle tissue development Source: Ensembl

    Keywords - Molecular functioni

    IntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation

    Keywords - Biological processi

    Cell adhesionUniRule annotationSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_198592. Molecules associated with elastic fibres.
    REACT_198757. ECM proteoglycans.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Itga8Imported
    Submitted name:
    RGD1564327 proteinImported
    Gene namesi
    Name:Itga8Imported
    Synonyms:RGD1564327Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi621634. Itga8.

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. dendritic spine membrane Source: RGD
    3. integrin complex Source: InterPro
    4. perikaryon Source: RGD
    5. postsynaptic density Source: RGD

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriB5DEG1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022713.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.UniRule annotation
    Contains FG-GAP repeats.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiNOG26407.
    GeneTreeiENSGT00750000117267.
    HOGENOMiHOG000231603.
    HOVERGENiHBG006186.
    KOiK06584.
    OMAiCRQIPFD.
    OrthoDBiEOG7HQN77.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 6 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5DEG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSARTHRGPP ENWAPPFACL CCVSAVLGML WSPVSLAFNL DVDKLTVYSG     50
    PEGSYFGYSL DFYIPDARTA SVLVGAPKAN TSQPDIVEGG AVYYCPWPAE 100
    RSAQCKQIPF DTTNNRKIRV NGTKEPIEFK SNQWFGATVR AHKGKVVACA 150
    PLYHWRTLKP NPAKDPVGTC YVAIQNFSAY AEHSPCRNSN VDPEGQGYCQ 200
    AGFSLDFYKN GDLIVGGPGS FYWQGQVITV SVADIIANYS FKDILRKLAA 250
    EKQTDVAPAS YDDSYLGYSV AAGEFTGDSL QELVAGIPRG AQNFGYVSII 300
    NSTDMTFIQN FTGEQMASYF GYTVVVSDVN NDGMDDILVG APLFMEREFE 350
    SNPREVGQVY LYLQVSALLF QDPQVLTGTE TFGRFGSSVA HLGDLNQDGY 400
    NDIAIGVPFA GKDQRGKVLI YNGNARGLHS KPSQVLQGIW GSQTIPSGFG 450
    FSLRGDADID KNDYPDLLVG AFGEGKVAVY RARPVVTVDA QLLLHPMIIN 500
    LENKTCQIPE FPTPVACFSL RVCASIAGQS ISNTVALMAE VQLDFLKQKG 550
    AIKRTLFLHN HQSHLIFPFV MRQQKSLHCQ DFMVYLRDET EFRDKLSPIN 600
    VSLNYSLDDS TFEDGLEVKP ILNHYRENVV TEQAHILVDC GEDNLCVPDL 650
    RLSARPDKQE IIIGDENHLM LIINARNEGE GAYEAELFVM IPEEADYVGI 700
    ERNNKGLRLL SCEYKMENVT RMVVCDLGNP MVTGTNFSLG LRFAVPRLEK 750
    TNMSINFDLQ IRSSNKDNPD SNFVSVQINV TAVAQVEIRG VSHPPQIVLP 800
    IHNWEPAEEP HKEEEVGPLV EHIYELHNIG PSTISDSILE VGWPFSAREE 850
    FLLYVFHLQT LGPLQCQTNP EINPQDIKPA ASPEDTPELS AFLRNATIPH 900
    LVRKRDVPVV QPHRQSPAKI LNCTNIDCLQ ISCAVGRLGG GESAVLKVRS 950
    RLWAHTFLQR KNDPYALASL VSFEVKKIPY KEQPAKLPAG STAIKTSVIW 1000
    ATPNVSFSIP LWVIILAILL GLLVLAILTL ALWKCGFFDR ARPPQDEMTD 1050
    REQLTSDKTP EA 1062
    Length:1,062
    Mass (Da):117,575
    Last modified:October 14, 2008 - v1
    Checksum:i24F33BC97E4B670C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06093120 Genomic DNA. No translation available.
    AABR06093121 Genomic DNA. No translation available.
    AABR06093122 Genomic DNA. No translation available.
    AABR06093123 Genomic DNA. No translation available.
    AABR06093124 Genomic DNA. No translation available.
    AABR06093125 Genomic DNA. No translation available.
    AABR06093126 Genomic DNA. No translation available.
    AABR06093127 Genomic DNA. No translation available.
    AABR06093128 Genomic DNA. No translation available.
    AABR06093129 Genomic DNA. No translation available.
    AABR06093130 Genomic DNA. No translation available.
    AABR06093131 Genomic DNA. No translation available.
    AABR06093132 Genomic DNA. No translation available.
    AABR06093133 Genomic DNA. No translation available.
    AABR06093134 Genomic DNA. No translation available.
    AABR06093135 Genomic DNA. No translation available.
    AABR06093136 Genomic DNA. No translation available.
    AABR06093137 Genomic DNA. No translation available.
    BC168655 mRNA. Translation: AAI68655.1.
    RefSeqiNP_001167443.1. NM_001173972.1.
    UniGeneiRn.69726.

    Genome annotation databases

    EnsembliENSRNOT00000022711; ENSRNOP00000022713; ENSRNOG00000016538.
    GeneIDi364786.
    KEGGirno:364786.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06093120 Genomic DNA. No translation available.
    AABR06093121 Genomic DNA. No translation available.
    AABR06093122 Genomic DNA. No translation available.
    AABR06093123 Genomic DNA. No translation available.
    AABR06093124 Genomic DNA. No translation available.
    AABR06093125 Genomic DNA. No translation available.
    AABR06093126 Genomic DNA. No translation available.
    AABR06093127 Genomic DNA. No translation available.
    AABR06093128 Genomic DNA. No translation available.
    AABR06093129 Genomic DNA. No translation available.
    AABR06093130 Genomic DNA. No translation available.
    AABR06093131 Genomic DNA. No translation available.
    AABR06093132 Genomic DNA. No translation available.
    AABR06093133 Genomic DNA. No translation available.
    AABR06093134 Genomic DNA. No translation available.
    AABR06093135 Genomic DNA. No translation available.
    AABR06093136 Genomic DNA. No translation available.
    AABR06093137 Genomic DNA. No translation available.
    BC168655 mRNA. Translation: AAI68655.1 .
    RefSeqi NP_001167443.1. NM_001173972.1.
    UniGenei Rn.69726.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022713.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022711 ; ENSRNOP00000022713 ; ENSRNOG00000016538 .
    GeneIDi 364786.
    KEGGi rno:364786.

    Organism-specific databases

    CTDi 8516.
    RGDi 621634. Itga8.

    Phylogenomic databases

    eggNOGi NOG26407.
    GeneTreei ENSGT00750000117267.
    HOGENOMi HOG000231603.
    HOVERGENi HBG006186.
    KOi K06584.
    OMAi CRQIPFD.
    OrthoDBi EOG7HQN77.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_198592. Molecules associated with elastic fibres.
    REACT_198757. ECM proteoglycans.

    Miscellaneous databases

    NextBioi 686038.
    PROi B5DEG1.

    Gene expression databases

    Genevestigatori B5DEG1.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 6 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiB5DEG1_RAT
    AccessioniPrimary (citable) accession number: B5DEG1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 14, 2008
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3