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Protein
Submitted name:

Integrin subunit alpha 8

Gene

Itga8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-2129379. Molecules associated with elastic fibres.
R-RNO-216083. Integrin cell surface interactions.
R-RNO-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin subunit alpha 8Imported
Submitted name:
RGD1564327 proteinImported
Gene namesi
Name:Itga8Imported
Synonyms:RGD1564327Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621634. Itga8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1011 – 1033HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000016538.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 104FG-GAPPROSITE-ProRule annotationAdd BLAST64
Repeati121 – 182FG-GAPPROSITE-ProRule annotationAdd BLAST62
Repeati187 – 239FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati252 – 305FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati306 – 371FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati372 – 430FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati434 – 497FG-GAPPROSITE-ProRule annotationAdd BLAST64
Domaini482 – 933Integrin_alpha2InterPro annotationAdd BLAST452

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
KOiK06584.
OMAiCRQIPFD.
OrthoDBiEOG091G05Z4.
TreeFamiTF105391.

Family and domain databases

InterProiView protein in InterPro
IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
PfamiView protein in Pfam
PF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PRINTSiPR01185. INTEGRINA.
SMARTiView protein in SMART
SM00191. Int_alpha. 6 hits.
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiView protein in PROSITE
PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.

Sequencei

Sequence statusi: Complete.

B5DEG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARTHRGPP ENWAPPFACL CCVSAVLGML WSPVSLAFNL DVDKLTVYSG
60 70 80 90 100
PEGSYFGYSL DFYIPDARTA SVLVGAPKAN TSQPDIVEGG AVYYCPWPAE
110 120 130 140 150
RSAQCKQIPF DTTNNRKIRV NGTKEPIEFK SNQWFGATVR AHKGKVVACA
160 170 180 190 200
PLYHWRTLKP NPAKDPVGTC YVAIQNFSAY AEHSPCRNSN VDPEGQGYCQ
210 220 230 240 250
AGFSLDFYKN GDLIVGGPGS FYWQGQVITV SVADIIANYS FKDILRKLAA
260 270 280 290 300
EKQTDVAPAS YDDSYLGYSV AAGEFTGDSL QELVAGIPRG AQNFGYVSII
310 320 330 340 350
NSTDMTFIQN FTGEQMASYF GYTVVVSDVN NDGMDDILVG APLFMEREFE
360 370 380 390 400
SNPREVGQVY LYLQVSALLF QDPQVLTGTE TFGRFGSSVA HLGDLNQDGY
410 420 430 440 450
NDIAIGVPFA GKDQRGKVLI YNGNARGLHS KPSQVLQGIW GSQTIPSGFG
460 470 480 490 500
FSLRGDADID KNDYPDLLVG AFGEGKVAVY RARPVVTVDA QLLLHPMIIN
510 520 530 540 550
LENKTCQIPE FPTPVACFSL RVCASIAGQS ISNTVALMAE VQLDFLKQKG
560 570 580 590 600
AIKRTLFLHN HQSHLIFPFV MRQQKSLHCQ DFMVYLRDET EFRDKLSPIN
610 620 630 640 650
VSLNYSLDDS TFEDGLEVKP ILNHYRENVV TEQAHILVDC GEDNLCVPDL
660 670 680 690 700
RLSARPDKQE IIIGDENHLM LIINARNEGE GAYEAELFVM IPEEADYVGI
710 720 730 740 750
ERNNKGLRLL SCEYKMENVT RMVVCDLGNP MVTGTNFSLG LRFAVPRLEK
760 770 780 790 800
TNMSINFDLQ IRSSNKDNPD SNFVSVQINV TAVAQVEIRG VSHPPQIVLP
810 820 830 840 850
IHNWEPAEEP HKEEEVGPLV EHIYELHNIG PSTISDSILE VGWPFSAREE
860 870 880 890 900
FLLYVFHLQT LGPLQCQTNP EINPQDIKPA ASPEDTPELS AFLRNATIPH
910 920 930 940 950
LVRKRDVPVV QPHRQSPAKI LNCTNIDCLQ ISCAVGRLGG GESAVLKVRS
960 970 980 990 1000
RLWAHTFLQR KNDPYALASL VSFEVKKIPY KEQPAKLPAG STAIKTSVIW
1010 1020 1030 1040 1050
ATPNVSFSIP LWVIILAILL GLLVLAILTL ALWKCGFFDR ARPPQDEMTD
1060
REQLTSDKTP EA
Length:1,062
Mass (Da):117,575
Last modified:October 14, 2008 - v1
Checksum:i24F33BC97E4B670C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07028653 Genomic DNA. No translation available.
AABR07028654 Genomic DNA. No translation available.
AABR07028655 Genomic DNA. No translation available.
AABR07028656 Genomic DNA. No translation available.
AABR07028657 Genomic DNA. No translation available.
AABR07028658 Genomic DNA. No translation available.
AABR07028659 Genomic DNA. No translation available.
AABR07028660 Genomic DNA. No translation available.
AABR07028661 Genomic DNA. No translation available.
AABR07028662 Genomic DNA. No translation available.
BC168655 mRNA. Translation: AAI68655.1.
RefSeqiNP_001167443.1. NM_001173972.1.
UniGeneiRn.69726.

Genome annotation databases

EnsembliENSRNOT00000022711; ENSRNOP00000022713; ENSRNOG00000016538.
GeneIDi364786.
KEGGirno:364786.

Similar proteinsi

Entry informationi

Entry nameiB5DEG1_RAT
AccessioniPrimary (citable) accession number: B5DEG1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported