B5DEG1 (B5DEG1_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Itga8 Ensembl ENSRNOP00000022713

Submitted name:
RGD1564327 protein EMBL AAI68655.1

Gene names

Name:	RGD1564327 EMBL AAI68655.1 RGD 1564327
Synonyms:	Itga8 Ensembl ENSRNOP00000022713

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1062 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU003762.
Sequence similarities	Belongs to the integrin alpha chain family. RuleBase RU003762

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS013519 RuleBase RU003762
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS013519
Molecular function	Integrin SAAS SAAS013519 RuleBase RU003762 Receptor SAAS SAAS013519 RuleBase RU003762
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell projection organization Inferred from electronic annotation. Source: Compara establishment of protein localization Inferred from electronic annotation. Source: Compara extracellular matrix organization Inferred from electronic annotation. Source: Compara inner ear morphogenesis Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW memory Inferred from electronic annotation. Source: Compara metanephros development Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara smooth muscle tissue development Inferred from electronic annotation. Source: Compara
Cellular_component	apical part of cell Inferred from electronic annotation. Source: Compara integrin complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5DEG1 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 24F33BC97E4B670C	FASTA	1,062	117,575
	10 20 30 40 50 60 MSARTHRGPP ENWAPPFACL CCVSAVLGML WSPVSLAFNL DVDKLTVYSG PEGSYFGYSL 70 80 90 100 110 120 DFYIPDARTA SVLVGAPKAN TSQPDIVEGG AVYYCPWPAE RSAQCKQIPF DTTNNRKIRV 130 140 150 160 170 180 NGTKEPIEFK SNQWFGATVR AHKGKVVACA PLYHWRTLKP NPAKDPVGTC YVAIQNFSAY 190 200 210 220 230 240 AEHSPCRNSN VDPEGQGYCQ AGFSLDFYKN GDLIVGGPGS FYWQGQVITV SVADIIANYS 250 260 270 280 290 300 FKDILRKLAA EKQTDVAPAS YDDSYLGYSV AAGEFTGDSL QELVAGIPRG AQNFGYVSII 310 320 330 340 350 360 NSTDMTFIQN FTGEQMASYF GYTVVVSDVN NDGMDDILVG APLFMEREFE SNPREVGQVY 370 380 390 400 410 420 LYLQVSALLF QDPQVLTGTE TFGRFGSSVA HLGDLNQDGY NDIAIGVPFA GKDQRGKVLI 430 440 450 460 470 480 YNGNARGLHS KPSQVLQGIW GSQTIPSGFG FSLRGDADID KNDYPDLLVG AFGEGKVAVY 490 500 510 520 530 540 RARPVVTVDA QLLLHPMIIN LENKTCQIPE FPTPVACFSL RVCASIAGQS ISNTVALMAE 550 560 570 580 590 600 VQLDFLKQKG AIKRTLFLHN HQSHLIFPFV MRQQKSLHCQ DFMVYLRDET EFRDKLSPIN 610 620 630 640 650 660 VSLNYSLDDS TFEDGLEVKP ILNHYRENVV TEQAHILVDC GEDNLCVPDL RLSARPDKQE 670 680 690 700 710 720 IIIGDENHLM LIINARNEGE GAYEAELFVM IPEEADYVGI ERNNKGLRLL SCEYKMENVT 730 740 750 760 770 780 RMVVCDLGNP MVTGTNFSLG LRFAVPRLEK TNMSINFDLQ IRSSNKDNPD SNFVSVQINV 790 800 810 820 830 840 TAVAQVEIRG VSHPPQIVLP IHNWEPAEEP HKEEEVGPLV EHIYELHNIG PSTISDSILE 850 860 870 880 890 900 VGWPFSAREE FLLYVFHLQT LGPLQCQTNP EINPQDIKPA ASPEDTPELS AFLRNATIPH 910 920 930 940 950 960 LVRKRDVPVV QPHRQSPAKI LNCTNIDCLQ ISCAVGRLGG GESAVLKVRS RLWAHTFLQR 970 980 990 1000 1010 1020 KNDPYALASL VSFEVKKIPY KEQPAKLPAG STAIKTSVIW ATPNVSFSIP LWVIILAILL 1030 1040 1050 1060 GLLVLAILTL ALWKCGFFDR ARPPQDEMTD REQLTSDKTP EA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung EMBL AAI68655.1.
[2]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000022713.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000022713.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06093120 Genomic DNA. No translation available. AABR06093121 Genomic DNA. No translation available. AABR06093122 Genomic DNA. No translation available. AABR06093123 Genomic DNA. No translation available. AABR06093124 Genomic DNA. No translation available. AABR06093125 Genomic DNA. No translation available. AABR06093126 Genomic DNA. No translation available. AABR06093127 Genomic DNA. No translation available. AABR06093128 Genomic DNA. No translation available. AABR06093129 Genomic DNA. No translation available. AABR06093130 Genomic DNA. No translation available. AABR06093131 Genomic DNA. No translation available. AABR06093132 Genomic DNA. No translation available. AABR06093133 Genomic DNA. No translation available. AABR06093134 Genomic DNA. No translation available. AABR06093135 Genomic DNA. No translation available. AABR06093136 Genomic DNA. No translation available. AABR06093137 Genomic DNA. No translation available. BC168655 mRNA. Translation: AAI68655.1.
IPI	IPI00763134.
RefSeq	NP_001167443.1. NM_001173972.1.
UniGene	Rn.69726.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000022713.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022711; ENSRNOP00000022713; ENSRNOG00000016538.
GeneID	364786.
KEGG	rno:364786.
Organism-specific databases
CTD	8516.
RGD	621634. Itga8.
Phylogenomic databases
eggNOG	NOG26407.
GeneTree	ENSGT00700000104007.
HOGENOM	HOG000231603.
HOVERGEN	HBG006186.
KO	K06584.
OMA	ESNPREV.
OrthoDB	EOG4548XV.
Gene expression databases
Genevestigator	B5DEG1.
Family and domain databases
InterPro	IPR013519. Int_alpha_beta-p. IPR000413. Integrin_alpha. IPR013649. Integrin_alpha-2. IPR018184. Integrin_alpha_C_CS. [Graphical view]
Pfam	PF00357. Integrin_alpha. 1 hit. PF08441. Integrin_alpha2. 1 hit. [Graphical view]
PRINTS	PR01185. INTEGRINA.
SMART	SM00191. Int_alpha. 6 hits. [Graphical view]
PROSITE	PS51470. FG_GAP. 7 hits. PS00242. INTEGRIN_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	686038.

Entry information

Entry name

B5DEG1_RAT

Accession

Primary (citable) accession number: B5DEG1

Entry history

Integrated into UniProtKB/TrEMBL:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)