Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B5DEG1 (B5DEG1_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

RGD1564327 protein EMBL AAI68655.1
Gene names
Name:Itga8 Ensembl ENSRNOP00000022713 RGD 621634
Synonyms:RGD1564327 EMBL AAI68655.1 RGD 1564327
OrganismRattus norvegicus (Rat) [Reference proteome] EMBL AAI68655.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1062 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein By similarity RuleBase RU003762.

Sequence similarities

Belongs to the integrin alpha chain family. RuleBase RU003762

Contains FG-GAP repeats. SAAS SAAS013649

Ontologies

Keywords
   Biological processCell adhesion RuleBase RU003762 SAAS SAAS013649
   Cellular componentMembrane
   DomainRepeat SAAS SAAS013649
Transmembrane
Transmembrane helix SAAS SAAS013649
   Molecular functionIntegrin RuleBase RU003762 SAAS SAAS013649
Receptor RuleBase RU003762 SAAS SAAS013649
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from expression pattern PubMed 8797161. Source: RGD

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

cell projection organization

Inferred from electronic annotation. Source: Ensembl

establishment of protein localization

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

inner ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

memory

Inferred from electronic annotation. Source: Ensembl

metanephros development

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

smooth muscle tissue development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical part of cell

Inferred from electronic annotation. Source: Ensembl

dendritic spine membrane

Inferred from direct assay PubMed 8797161. Source: RGD

integrin complex

Inferred from electronic annotation. Source: InterPro

perikaryon

Inferred from direct assay PubMed 8797161. Source: RGD

postsynaptic density

Inferred from direct assay PubMed 8797161. Source: RGD

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B5DEG1 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 24F33BC97E4B670C

FASTA1,062117,575
        10         20         30         40         50         60 
MSARTHRGPP ENWAPPFACL CCVSAVLGML WSPVSLAFNL DVDKLTVYSG PEGSYFGYSL 

        70         80         90        100        110        120 
DFYIPDARTA SVLVGAPKAN TSQPDIVEGG AVYYCPWPAE RSAQCKQIPF DTTNNRKIRV 

       130        140        150        160        170        180 
NGTKEPIEFK SNQWFGATVR AHKGKVVACA PLYHWRTLKP NPAKDPVGTC YVAIQNFSAY 

       190        200        210        220        230        240 
AEHSPCRNSN VDPEGQGYCQ AGFSLDFYKN GDLIVGGPGS FYWQGQVITV SVADIIANYS 

       250        260        270        280        290        300 
FKDILRKLAA EKQTDVAPAS YDDSYLGYSV AAGEFTGDSL QELVAGIPRG AQNFGYVSII 

       310        320        330        340        350        360 
NSTDMTFIQN FTGEQMASYF GYTVVVSDVN NDGMDDILVG APLFMEREFE SNPREVGQVY 

       370        380        390        400        410        420 
LYLQVSALLF QDPQVLTGTE TFGRFGSSVA HLGDLNQDGY NDIAIGVPFA GKDQRGKVLI 

       430        440        450        460        470        480 
YNGNARGLHS KPSQVLQGIW GSQTIPSGFG FSLRGDADID KNDYPDLLVG AFGEGKVAVY 

       490        500        510        520        530        540 
RARPVVTVDA QLLLHPMIIN LENKTCQIPE FPTPVACFSL RVCASIAGQS ISNTVALMAE 

       550        560        570        580        590        600 
VQLDFLKQKG AIKRTLFLHN HQSHLIFPFV MRQQKSLHCQ DFMVYLRDET EFRDKLSPIN 

       610        620        630        640        650        660 
VSLNYSLDDS TFEDGLEVKP ILNHYRENVV TEQAHILVDC GEDNLCVPDL RLSARPDKQE 

       670        680        690        700        710        720 
IIIGDENHLM LIINARNEGE GAYEAELFVM IPEEADYVGI ERNNKGLRLL SCEYKMENVT 

       730        740        750        760        770        780 
RMVVCDLGNP MVTGTNFSLG LRFAVPRLEK TNMSINFDLQ IRSSNKDNPD SNFVSVQINV 

       790        800        810        820        830        840 
TAVAQVEIRG VSHPPQIVLP IHNWEPAEEP HKEEEVGPLV EHIYELHNIG PSTISDSILE 

       850        860        870        880        890        900 
VGWPFSAREE FLLYVFHLQT LGPLQCQTNP EINPQDIKPA ASPEDTPELS AFLRNATIPH 

       910        920        930        940        950        960 
LVRKRDVPVV QPHRQSPAKI LNCTNIDCLQ ISCAVGRLGG GESAVLKVRS RLWAHTFLQR 

       970        980        990       1000       1010       1020 
KNDPYALASL VSFEVKKIPY KEQPAKLPAG STAIKTSVIW ATPNVSFSIP LWVIILAILL 

      1030       1040       1050       1060 
GLLVLAILTL ALWKCGFFDR ARPPQDEMTD REQLTSDKTP EA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung EMBL AAI68655.1.
[2]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000022713.
[3]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000022713.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06093120 Genomic DNA. No translation available.
AABR06093121 Genomic DNA. No translation available.
AABR06093122 Genomic DNA. No translation available.
AABR06093123 Genomic DNA. No translation available.
AABR06093124 Genomic DNA. No translation available.
AABR06093125 Genomic DNA. No translation available.
AABR06093126 Genomic DNA. No translation available.
AABR06093127 Genomic DNA. No translation available.
AABR06093128 Genomic DNA. No translation available.
AABR06093129 Genomic DNA. No translation available.
AABR06093130 Genomic DNA. No translation available.
AABR06093131 Genomic DNA. No translation available.
AABR06093132 Genomic DNA. No translation available.
AABR06093133 Genomic DNA. No translation available.
AABR06093134 Genomic DNA. No translation available.
AABR06093135 Genomic DNA. No translation available.
AABR06093136 Genomic DNA. No translation available.
AABR06093137 Genomic DNA. No translation available.
BC168655 mRNA. Translation: AAI68655.1.
RefSeqNP_001167443.1. NM_001173972.1.
UniGeneRn.69726.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000022713.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022711; ENSRNOP00000022713; ENSRNOG00000016538.
GeneID364786.
KEGGrno:364786.

Organism-specific databases

CTD8516.
RGD621634. Itga8.

Phylogenomic databases

eggNOGNOG26407.
GeneTreeENSGT00750000117267.
HOGENOMHOG000231603.
HOVERGENHBG006186.
KOK06584.
OMACRQIPFD.
OrthoDBEOG7HQN77.
PhylomeDBB5DEG1.
TreeFamTF105391.

Gene expression databases

GenevestigatorB5DEG1.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 6 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio686038.
PROB5DEG1.

Entry information

Entry nameB5DEG1_RAT
AccessionPrimary (citable) accession number: B5DEG1
Entry history
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)