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Protein

Cyclin-dependent kinase 12

Gene

cdk12

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating srsf1/sf2 (By similarity).By similarity

Catalytic activityi

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei739ATPPROSITE-ProRule annotation1
Active sitei842Proton acceptorPROSITE-ProRule annotation1
Binding sitei1023ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi716 – 724ATPPROSITE-ProRule annotation9
Nucleotide bindingi797 – 802ATPPROSITE-ProRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 12 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 12
Gene namesi
Name:cdk12
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-493308 cdk12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004069591 – 1239Cyclin-dependent kinase 12Add BLAST1239

Proteomic databases

PaxDbiB5DE93
PRIDEiB5DE93

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000043552

Structurei

3D structure databases

ProteinModelPortaliB5DE93
SMRiB5DE93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini710 – 1003Protein kinasePROSITE-ProRule annotationAdd BLAST294

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi163 – 383Ser-richAdd BLAST221
Compositional biasi396 – 402Poly-Ala7
Compositional biasi507 – 690Pro-richAdd BLAST184
Compositional biasi1214 – 1218Poly-Glu5
Compositional biasi1227 – 1231Poly-Glu5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0600 Eukaryota
ENOG410XPIR LUCA
HOVERGENiHBG050852
InParanoidiB5DE93
KOiK08819

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

B5DE93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNPVRHGNK KDSGGSASTM PESSGSVNNK DRQRISSKHK RHKSKHLRES
60 70 80 90 100
SVPEPQTLST LKLVEYDDIS SDSDTFSDVP AKQERRENDE RRPSEKSDKM
110 120 130 140 150
HKSRHRHQHK RLKEATRTKQ VEKERKPEKT QEVMVNKVPS SKDKIISSAK
160 170 180 190 200
RTADEQEEHG RTSKSSSKDS RSKMHKDKSR REREMKSGHK ERSKSHRKRD
210 220 230 240 250
SSKRYKTSDS PKRKGRSPRR KYGGSPKQDD SHSEGSCGQD YDDSPSRVHA
260 270 280 290 300
SGNFNETYRK NMDSPSYKEP AAYQSSARSP SPYSRKQRSV SPYRRRSSSY
310 320 330 340 350
ERGSGSYSGR SPSPYVRRRS SSPFVSRRSL SRSPAPRKSA KSRSRSPLYP
360 370 380 390 400
RKSSSSSRSK KQKSQSRSRH SSISPARLPL NSSLGAELSR KKKEIAAAAA
410 420 430 440 450
AAGRESKGSP LILKKESGDS RVASALDLKK ATKVLKLEKP VSEPEMVTAT
460 470 480 490 500
SSETKTISAK KEESEKKPQV QAKDPKISGL KDCKPAAIKE EVLTPKEGVT
510 520 530 540 550
DRDKDVPPLP PILSPPPPLP TSPPSNIPPL PPLPPSPAVL QQPPPPLPPP
560 570 580 590 600
PTLTFLPLPT TVAASLTSSH YVRQSSLSTQ ANSQLPVPSP AKPQPPLIHM
610 620 630 640 650
VPHMKTSTLP PLPLPPLLLG EDDIESPKEI PPPKSVKKEK DKDRPRHLLT
660 670 680 690 700
DLPLPPELPG GDPSPPDSPE RKVVAPPQPP LKKRPKICCP RYGERKQTET
710 720 730 740 750
DWGKRCVDKF DIIGIIGEGT YGQVYKAKDK DTGELVALKK VRLDNEKEGF
760 770 780 790 800
PITAIREIKI LRQLIHKSVV NMKEIVTDKQ DALDFKKDKG AFYLVFEYMD
810 820 830 840 850
HDLMGLLESG LVQFSEDHIK SFMKQLMEGL EYCHKKNFLH RDIKCSNILL
860 870 880 890 900
NNSGQIKLAD FGLARLYSSE ESRPYTNKVI TLWYRPPELL LGEERYTPAI
910 920 930 940 950
DVWSCGCILG ELFTKKPIFQ ANQELAQLEL ISRLCGSPCP AVWPDVIKLP
960 970 980 990 1000
YFNTMKPKKQ YRRRLREEFS FVPTPALDLL DHMLTLDPSK RCTAEQTLQS
1010 1020 1030 1040 1050
DFLKDVDVCK MATPDLPHWQ DCHELWSKKR RRQRQSGIVL EEPPAIKAPR
1060 1070 1080 1090 1100
KESVSVPGGD AMKNSSPAPT QPVKTESSVS DLAVLGDITQ QLNQSELAVL
1110 1120 1130 1140 1150
LNLLQSQTDL SVSQISQLLN VQANPDMQLQ LEALNQSITA LTGAAVPPQE
1160 1170 1180 1190 1200
VEPPKETPTL DQVDPLGAGT QGEVQNVLAV LLSQLLKPQE VVDAPGESNG
1210 1220 1230
EQSGSNPTAH ITLEEEEEPD KHHEQNEEEE EDAGNYWSP
Length:1,239
Mass (Da):138,328
Last modified:October 14, 2008 - v1
Checksum:i8ADF1CECFCE9CB12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168577 mRNA Translation: AAI68577.1
RefSeqiNP_001128283.1, NM_001134811.1
UniGeneiStr.6962

Genome annotation databases

GeneIDi100038049
KEGGixtr:100038049

Similar proteinsi

Entry informationi

Entry nameiCDK12_XENTR
AccessioniPrimary (citable) accession number: B5DE93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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