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B5DE93

- CDK12_XENTR

UniProt

B5DE93 - CDK12_XENTR

Protein

Cyclin-dependent kinase 12

Gene

cdk12

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating srsf1/sf2 By similarity.By similarity

    Catalytic activityi

    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei739 – 7391ATPPROSITE-ProRule annotation
    Active sitei842 – 8421Proton acceptorPROSITE-ProRule annotation
    Binding sitei1023 – 10231ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi716 – 7249ATPPROSITE-ProRule annotation
    Nucleotide bindingi797 – 8026ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
    3. regulation of MAP kinase activity Source: UniProtKB
    4. RNA splicing Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 12 (EC:2.7.11.22, EC:2.7.11.23)
    Alternative name(s):
    Cell division protein kinase 12
    Gene namesi
    Name:cdk12
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-493308. cdk12.

    Subcellular locationi

    Nucleus By similarity. Nucleus speckle By similarity

    GO - Cellular componenti

    1. nuclear cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
    2. nuclear speck Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12391239Cyclin-dependent kinase 12PRO_0000406959Add
    BLAST

    Proteomic databases

    PRIDEiB5DE93.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000051128.

    Structurei

    3D structure databases

    ProteinModelPortaliB5DE93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini710 – 1003294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi163 – 383221Ser-richAdd
    BLAST
    Compositional biasi396 – 4027Poly-Ala
    Compositional biasi507 – 690184Pro-richAdd
    BLAST
    Compositional biasi1214 – 12185Poly-Glu
    Compositional biasi1227 – 12315Poly-Glu

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG050852.
    KOiK08819.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5DE93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNPVRHGNK KDSGGSASTM PESSGSVNNK DRQRISSKHK RHKSKHLRES     50
    SVPEPQTLST LKLVEYDDIS SDSDTFSDVP AKQERRENDE RRPSEKSDKM 100
    HKSRHRHQHK RLKEATRTKQ VEKERKPEKT QEVMVNKVPS SKDKIISSAK 150
    RTADEQEEHG RTSKSSSKDS RSKMHKDKSR REREMKSGHK ERSKSHRKRD 200
    SSKRYKTSDS PKRKGRSPRR KYGGSPKQDD SHSEGSCGQD YDDSPSRVHA 250
    SGNFNETYRK NMDSPSYKEP AAYQSSARSP SPYSRKQRSV SPYRRRSSSY 300
    ERGSGSYSGR SPSPYVRRRS SSPFVSRRSL SRSPAPRKSA KSRSRSPLYP 350
    RKSSSSSRSK KQKSQSRSRH SSISPARLPL NSSLGAELSR KKKEIAAAAA 400
    AAGRESKGSP LILKKESGDS RVASALDLKK ATKVLKLEKP VSEPEMVTAT 450
    SSETKTISAK KEESEKKPQV QAKDPKISGL KDCKPAAIKE EVLTPKEGVT 500
    DRDKDVPPLP PILSPPPPLP TSPPSNIPPL PPLPPSPAVL QQPPPPLPPP 550
    PTLTFLPLPT TVAASLTSSH YVRQSSLSTQ ANSQLPVPSP AKPQPPLIHM 600
    VPHMKTSTLP PLPLPPLLLG EDDIESPKEI PPPKSVKKEK DKDRPRHLLT 650
    DLPLPPELPG GDPSPPDSPE RKVVAPPQPP LKKRPKICCP RYGERKQTET 700
    DWGKRCVDKF DIIGIIGEGT YGQVYKAKDK DTGELVALKK VRLDNEKEGF 750
    PITAIREIKI LRQLIHKSVV NMKEIVTDKQ DALDFKKDKG AFYLVFEYMD 800
    HDLMGLLESG LVQFSEDHIK SFMKQLMEGL EYCHKKNFLH RDIKCSNILL 850
    NNSGQIKLAD FGLARLYSSE ESRPYTNKVI TLWYRPPELL LGEERYTPAI 900
    DVWSCGCILG ELFTKKPIFQ ANQELAQLEL ISRLCGSPCP AVWPDVIKLP 950
    YFNTMKPKKQ YRRRLREEFS FVPTPALDLL DHMLTLDPSK RCTAEQTLQS 1000
    DFLKDVDVCK MATPDLPHWQ DCHELWSKKR RRQRQSGIVL EEPPAIKAPR 1050
    KESVSVPGGD AMKNSSPAPT QPVKTESSVS DLAVLGDITQ QLNQSELAVL 1100
    LNLLQSQTDL SVSQISQLLN VQANPDMQLQ LEALNQSITA LTGAAVPPQE 1150
    VEPPKETPTL DQVDPLGAGT QGEVQNVLAV LLSQLLKPQE VVDAPGESNG 1200
    EQSGSNPTAH ITLEEEEEPD KHHEQNEEEE EDAGNYWSP 1239
    Length:1,239
    Mass (Da):138,328
    Last modified:October 14, 2008 - v1
    Checksum:i8ADF1CECFCE9CB12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC168577 mRNA. Translation: AAI68577.1.
    RefSeqiNP_001128283.1. NM_001134811.1.
    UniGeneiStr.6962.

    Genome annotation databases

    GeneIDi100038049.
    KEGGixtr:100038049.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC168577 mRNA. Translation: AAI68577.1 .
    RefSeqi NP_001128283.1. NM_001134811.1.
    UniGenei Str.6962.

    3D structure databases

    ProteinModelPortali B5DE93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000051128.

    Proteomic databases

    PRIDEi B5DE93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100038049.
    KEGGi xtr:100038049.

    Organism-specific databases

    CTDi 51755.
    Xenbasei XB-GENE-493308. cdk12.

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG050852.
    KOi K08819.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCDK12_XENTR
    AccessioniPrimary (citable) accession number: B5DE93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3