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B5D5N9

- CTR2_RAT

UniProt

B5D5N9 - CTR2_RAT

Protein

Low affinity cationic amino acid transporter 2

Gene

Slc7a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages By similarity.By similarity

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. arginine transport Source: RGD

    Keywords - Biological processi

    Amino-acid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity cationic amino acid transporter 2
    Short name:
    CAT-2
    Short name:
    CAT2
    Alternative name(s):
    Solute carrier family 7 member 2
    Gene namesi
    Name:Slc7a2
    Synonyms:Atrc2, Cat2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi68387. Slc7a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657Low affinity cationic amino acid transporter 2PRO_0000375227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Modified residuei645 – 6451PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiB5D5N9.
    PRIDEiB5D5N9.

    Expressioni

    Gene expression databases

    GenevestigatoriB5D5N9.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini60 – 667ExtracellularSequence Analysis
    Topological domaini88 – 10417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 16338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 1928CytoplasmicSequence Analysis
    Topological domaini214 – 24835ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini270 – 28920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini311 – 33929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 38525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini407 – 4093ExtracellularSequence Analysis
    Topological domaini431 – 48959CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini511 – 52313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini545 – 55410CytoplasmicSequence Analysis
    Topological domaini576 – 5816ExtracellularSequence Analysis
    Topological domaini603 – 65755CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei490 – 51021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei555 – 57521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei582 – 60221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00700000104437.
    HOGENOMiHOG000250623.
    KOiK13864.
    PhylomeDBiB5D5N9.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00906. 2A0303. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B5D5N9-1) [UniParc]FASTAAdd to Basket

    Also known as: CAT2A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIPCRAVLTF TRCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA    50
    GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY 100
    LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF 150
    KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL 200
    VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM 250
    PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 300
    MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS 350
    TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM 400
    AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYE QPKYTPEKDI 450
    LESCTNATSK SESQVTMLQG QGFSLRTLFN PSALPTRQSA SLVSFLVGFL 500
    AFLIAGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI LTIWRQPQNQ 550
    QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWVRFSIWM VLGFLIYFAY 600
    GIRHSLEGNP RDEEEDEDVC PDNVNAAAEE KSAMQANDHH QRNLSLPFIL 650
    HEKTSEC 657
    Length:657
    Mass (Da):71,694
    Last modified:October 14, 2008 - v1
    Checksum:i313E0A05771931B7
    GO
    Isoform 2 (identifier: B5D5N9-2) [UniParc]FASTAAdd to Basket

    Also known as: CAT2B

    The sequence of this isoform differs from the canonical sequence as follows:
         357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

    Show »
    Length:658
    Mass (Da):71,638
    Checksum:iCD5DF2B16FF172A8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei357 – 39741MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPIIATLSSGA VA in isoform 2. 1 PublicationVSP_037355Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245001 mRNA. Translation: AAQ14243.1.
    AF245002 mRNA. Translation: AAQ14244.1.
    CH473995 Genomic DNA. Translation: EDL78824.1.
    CH473995 Genomic DNA. Translation: EDL78825.1.
    RefSeqiNP_001128158.1. NM_001134686.2. [B5D5N9-2]
    NP_072141.2. NM_022619.3. [B5D5N9-1]
    UniGeneiRn.48707.

    Genome annotation databases

    EnsembliENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
    ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
    GeneIDi64554.
    KEGGirno:64554.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245001 mRNA. Translation: AAQ14243.1 .
    AF245002 mRNA. Translation: AAQ14244.1 .
    CH473995 Genomic DNA. Translation: EDL78824.1 .
    CH473995 Genomic DNA. Translation: EDL78825.1 .
    RefSeqi NP_001128158.1. NM_001134686.2. [B5D5N9-2 ]
    NP_072141.2. NM_022619.3. [B5D5N9-1 ]
    UniGenei Rn.48707.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi B5D5N9.
    PRIDEi B5D5N9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014809 ; ENSRNOP00000014809 ; ENSRNOG00000011016 . [B5D5N9-2 ]
    ENSRNOT00000015127 ; ENSRNOP00000015127 ; ENSRNOG00000011016 . [B5D5N9-1 ]
    GeneIDi 64554.
    KEGGi rno:64554.

    Organism-specific databases

    CTDi 6542.
    RGDi 68387. Slc7a2.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00700000104437.
    HOGENOMi HOG000250623.
    KOi K13864.
    PhylomeDBi B5D5N9.

    Miscellaneous databases

    NextBioi 613456.

    Gene expression databases

    Genevestigatori B5D5N9.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00906. 2A0303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Rattus cationic amino acid transporter-2 (rCAT-2) mRNA."
      Cui Z., Kelly J., Brzeski H., Marber M., Pearson J.D., Baydoun A.R.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: Wistar.
      Tissue: Aortic smooth muscle.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.

    Entry informationi

    Entry nameiCTR2_RAT
    AccessioniPrimary (citable) accession number: B5D5N9
    Secondary accession number(s): B5D5P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3