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B5D5N9

- CTR2_RAT

UniProt

B5D5N9 - CTR2_RAT

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Protein

Low affinity cationic amino acid transporter 2

Gene
Slc7a2, Atrc2, Cat2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages By similarity.

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: RGD

GO - Biological processi

  1. arginine transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity cationic amino acid transporter 2
Short name:
CAT-2
Short name:
CAT2
Alternative name(s):
Solute carrier family 7 member 2
Gene namesi
Name:Slc7a2
Synonyms:Atrc2, Cat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi68387. Slc7a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Topological domaini60 – 667Extracellular Reviewed prediction
Transmembranei67 – 8721Helical; Reviewed predictionAdd
BLAST
Topological domaini88 – 10417Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei105 – 12521Helical; Reviewed predictionAdd
BLAST
Topological domaini126 – 16338Extracellular Reviewed predictionAdd
BLAST
Transmembranei164 – 18421Helical; Reviewed predictionAdd
BLAST
Topological domaini185 – 1928Cytoplasmic Reviewed prediction
Transmembranei193 – 21321Helical; Reviewed predictionAdd
BLAST
Topological domaini214 – 24835Extracellular Reviewed predictionAdd
BLAST
Transmembranei249 – 26921Helical; Reviewed predictionAdd
BLAST
Topological domaini270 – 28920Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei290 – 31021Helical; Reviewed predictionAdd
BLAST
Topological domaini311 – 33929Extracellular Reviewed predictionAdd
BLAST
Transmembranei340 – 36021Helical; Reviewed predictionAdd
BLAST
Topological domaini361 – 38525Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei386 – 40621Helical; Reviewed predictionAdd
BLAST
Topological domaini407 – 4093Extracellular Reviewed prediction
Transmembranei410 – 43021Helical; Reviewed predictionAdd
BLAST
Topological domaini431 – 48959Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei490 – 51021Helical; Reviewed predictionAdd
BLAST
Topological domaini511 – 52313Extracellular Reviewed predictionAdd
BLAST
Transmembranei524 – 54421Helical; Reviewed predictionAdd
BLAST
Topological domaini545 – 55410Cytoplasmic Reviewed prediction
Transmembranei555 – 57521Helical; Reviewed predictionAdd
BLAST
Topological domaini576 – 5816Extracellular Reviewed prediction
Transmembranei582 – 60221Helical; Reviewed predictionAdd
BLAST
Topological domaini603 – 65755Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Low affinity cationic amino acid transporter 2PRO_0000375227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Modified residuei645 – 6451Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiB5D5N9.
PRIDEiB5D5N9.

Expressioni

Gene expression databases

GenevestigatoriB5D5N9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00700000104437.
HOGENOMiHOG000250623.
KOiK13864.
PhylomeDBiB5D5N9.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B5D5N9-1) [UniParc]FASTAAdd to Basket

Also known as: CAT2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIPCRAVLTF TRCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA    50
GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY 100
LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF 150
KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL 200
VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM 250
PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 300
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS 350
TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM 400
AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYE QPKYTPEKDI 450
LESCTNATSK SESQVTMLQG QGFSLRTLFN PSALPTRQSA SLVSFLVGFL 500
AFLIAGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI LTIWRQPQNQ 550
QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWVRFSIWM VLGFLIYFAY 600
GIRHSLEGNP RDEEEDEDVC PDNVNAAAEE KSAMQANDHH QRNLSLPFIL 650
HEKTSEC 657
Length:657
Mass (Da):71,694
Last modified:October 14, 2008 - v1
Checksum:i313E0A05771931B7
GO
Isoform 2 (identifier: B5D5N9-2) [UniParc]FASTAAdd to Basket

Also known as: CAT2B

The sequence of this isoform differs from the canonical sequence as follows:
     357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

Show »
Length:658
Mass (Da):71,638
Checksum:iCD5DF2B16FF172A8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei357 – 39741MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPIIATLSSGA VA in isoform 2. VSP_037355Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245001 mRNA. Translation: AAQ14243.1.
AF245002 mRNA. Translation: AAQ14244.1.
CH473995 Genomic DNA. Translation: EDL78824.1.
CH473995 Genomic DNA. Translation: EDL78825.1.
RefSeqiNP_001128158.1. NM_001134686.2. [B5D5N9-2]
NP_072141.2. NM_022619.3. [B5D5N9-1]
UniGeneiRn.48707.

Genome annotation databases

EnsembliENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
GeneIDi64554.
KEGGirno:64554.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245001 mRNA. Translation: AAQ14243.1 .
AF245002 mRNA. Translation: AAQ14244.1 .
CH473995 Genomic DNA. Translation: EDL78824.1 .
CH473995 Genomic DNA. Translation: EDL78825.1 .
RefSeqi NP_001128158.1. NM_001134686.2. [B5D5N9-2 ]
NP_072141.2. NM_022619.3. [B5D5N9-1 ]
UniGenei Rn.48707.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi B5D5N9.
PRIDEi B5D5N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014809 ; ENSRNOP00000014809 ; ENSRNOG00000011016 . [B5D5N9-2 ]
ENSRNOT00000015127 ; ENSRNOP00000015127 ; ENSRNOG00000011016 . [B5D5N9-1 ]
GeneIDi 64554.
KEGGi rno:64554.

Organism-specific databases

CTDi 6542.
RGDi 68387. Slc7a2.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00700000104437.
HOGENOMi HOG000250623.
KOi K13864.
PhylomeDBi B5D5N9.

Miscellaneous databases

NextBioi 613456.

Gene expression databases

Genevestigatori B5D5N9.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00906. 2A0303. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rattus cationic amino acid transporter-2 (rCAT-2) mRNA."
    Cui Z., Kelly J., Brzeski H., Marber M., Pearson J.D., Baydoun A.R.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Wistar.
    Tissue: Aortic smooth muscle.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiCTR2_RAT
AccessioniPrimary (citable) accession number: B5D5N9
Secondary accession number(s): B5D5P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 14, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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