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B5D5N9 (CTR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low affinity cationic amino acid transporter 2

Short name=CAT-2
Short name=CAT2
Alternative name(s):
Solute carrier family 7 member 2
Gene names
Name:Slc7a2
Synonyms:Atrc2, Cat2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B5D5N9-1)

Also known as: CAT2A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B5D5N9-2)

Also known as: CAT2B;

The sequence of this isoform differs from the canonical sequence as follows:
     357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657Low affinity cationic amino acid transporter 2
PRO_0000375227

Regions

Topological domain1 – 3838Cytoplasmic Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 667Extracellular Potential
Transmembrane67 – 8721Helical; Potential
Topological domain88 – 10417Cytoplasmic Potential
Transmembrane105 – 12521Helical; Potential
Topological domain126 – 16338Extracellular Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 1928Cytoplasmic Potential
Transmembrane193 – 21321Helical; Potential
Topological domain214 – 24835Extracellular Potential
Transmembrane249 – 26921Helical; Potential
Topological domain270 – 28920Cytoplasmic Potential
Transmembrane290 – 31021Helical; Potential
Topological domain311 – 33929Extracellular Potential
Transmembrane340 – 36021Helical; Potential
Topological domain361 – 38525Cytoplasmic Potential
Transmembrane386 – 40621Helical; Potential
Topological domain407 – 4093Extracellular Potential
Transmembrane410 – 43021Helical; Potential
Topological domain431 – 48959Cytoplasmic Potential
Transmembrane490 – 51021Helical; Potential
Topological domain511 – 52313Extracellular Potential
Transmembrane524 – 54421Helical; Potential
Topological domain545 – 55410Cytoplasmic Potential
Transmembrane555 – 57521Helical; Potential
Topological domain576 – 5816Extracellular Potential
Transmembrane582 – 60221Helical; Potential
Topological domain603 – 65755Cytoplasmic Potential

Amino acid modifications

Modified residue6451Phosphoserine By similarity
Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence357 – 39741MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPIIATLSSGA VA in isoform 2.
VSP_037355

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CAT2A) [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 313E0A05771931B7

FASTA65771,694
        10         20         30         40         50         60 
MIPCRAVLTF TRCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA GVYVLAGEVA 

        70         80         90        100        110        120 
KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI 

       130        140        150        160        170        180 
LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL 

       190        200        210        220        230        240 
SFGVKESAWV NKFFTAINIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG 

       250        260        270        280        290        300 
TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 

       310        320        330        340        350        360 
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS TSLLGSMFPL 

       370        380        390        400        410        420 
PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM AFLFDLKALV DMMSIGTLMA 

       430        440        450        460        470        480 
YSLVAACVLI LRYQPGLCYE QPKYTPEKDI LESCTNATSK SESQVTMLQG QGFSLRTLFN 

       490        500        510        520        530        540 
PSALPTRQSA SLVSFLVGFL AFLIAGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI 

       550        560        570        580        590        600 
LTIWRQPQNQ QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWVRFSIWM VLGFLIYFAY 

       610        620        630        640        650 
GIRHSLEGNP RDEEEDEDVC PDNVNAAAEE KSAMQANDHH QRNLSLPFIL HEKTSEC 

« Hide

Isoform 2 (CAT2B) [UniParc].

Checksum: CD5DF2B16FF172A8
Show »

FASTA65871,638

References

« Hide 'large scale' references
[1]"Rattus cationic amino acid transporter-2 (rCAT-2) mRNA."
Cui Z., Kelly J., Brzeski H., Marber M., Pearson J.D., Baydoun A.R.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: Wistar.
Tissue: Aortic smooth muscle.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF245001 mRNA. Translation: AAQ14243.1.
AF245002 mRNA. Translation: AAQ14244.1.
CH473995 Genomic DNA. Translation: EDL78824.1.
CH473995 Genomic DNA. Translation: EDL78825.1.
RefSeqNP_001128158.1. NM_001134686.2.
NP_072141.2. NM_022619.3.
UniGeneRn.48707.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbB5D5N9.
PRIDEB5D5N9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
GeneID64554.
KEGGrno:64554.

Organism-specific databases

CTD6542.
RGD68387. Slc7a2.

Phylogenomic databases

eggNOGCOG0531.
GeneTreeENSGT00700000104437.
HOGENOMHOG000250623.
KOK13864.
PhylomeDBB5D5N9.

Gene expression databases

GenevestigatorB5D5N9.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00906. 2A0303. 1 hit.
ProtoNetSearch...

Other

NextBio613456.

Entry information

Entry nameCTR2_RAT
AccessionPrimary (citable) accession number: B5D5N9
Secondary accession number(s): B5D5P0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families