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Protein

Cationic amino acid transporter 2

Gene

Slc7a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). The affinity for its substrates differs between isoforms created by alternative splicing. May play a role in classical or alternative activation of macrophages via its role in arginine transport.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_311758. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 2
Short name:
CAT-2
Short name:
CAT2
Alternative name(s):
Low affinity cationic amino acid transporter 2
Solute carrier family 7 member 2
Gene namesi
Name:Slc7a2
Synonyms:Atrc2, Cat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi68387. Slc7a2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Topological domaini60 – 667ExtracellularSequence Analysis
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 10417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 16338ExtracellularSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Topological domaini185 – 1928CytoplasmicSequence Analysis
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Topological domaini214 – 24835ExtracellularSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Topological domaini270 – 28920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Topological domaini311 – 33929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence AnalysisAdd
BLAST
Topological domaini361 – 38525CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence AnalysisAdd
BLAST
Topological domaini407 – 4093ExtracellularSequence Analysis
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Topological domaini431 – 48959CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence AnalysisAdd
BLAST
Topological domaini511 – 52313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 55410CytoplasmicSequence Analysis
Transmembranei555 – 57521HelicalSequence AnalysisAdd
BLAST
Topological domaini576 – 5816ExtracellularSequence Analysis
Transmembranei582 – 60221HelicalSequence AnalysisAdd
BLAST
Topological domaini603 – 65755CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Cationic amino acid transporter 2PRO_0000375227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Modified residuei645 – 6451PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiB5D5N9.
PRIDEiB5D5N9.

Expressioni

Gene expression databases

ExpressionAtlasiB5D5N9. baseline.
GenevisibleiB5D5N9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055811.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
InParanoidiB5D5N9.
KOiK13864.
PhylomeDBiB5D5N9.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B5D5N9-1) [UniParc]FASTAAdd to basket

Also known as: CAT2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPCRAVLTF TRCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA
60 70 80 90 100
GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY
110 120 130 140 150
LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF
160 170 180 190 200
KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL
210 220 230 240 250
VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM
260 270 280 290 300
PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF
310 320 330 340 350
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS
360 370 380 390 400
TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM
410 420 430 440 450
AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYE QPKYTPEKDI
460 470 480 490 500
LESCTNATSK SESQVTMLQG QGFSLRTLFN PSALPTRQSA SLVSFLVGFL
510 520 530 540 550
AFLIAGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI LTIWRQPQNQ
560 570 580 590 600
QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWVRFSIWM VLGFLIYFAY
610 620 630 640 650
GIRHSLEGNP RDEEEDEDVC PDNVNAAAEE KSAMQANDHH QRNLSLPFIL

HEKTSEC
Length:657
Mass (Da):71,694
Last modified:October 14, 2008 - v1
Checksum:i313E0A05771931B7
GO
Isoform 2 (identifier: B5D5N9-2) [UniParc]FASTAAdd to basket

Also known as: CAT2B

The sequence of this isoform differs from the canonical sequence as follows:
     357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

Show »
Length:658
Mass (Da):71,638
Checksum:iCD5DF2B16FF172A8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei357 – 39741MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPIIATLSSGA VA in isoform 2. 1 PublicationVSP_037355Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245001 mRNA. Translation: AAQ14243.1.
AF245002 mRNA. Translation: AAQ14244.1.
CH473995 Genomic DNA. Translation: EDL78824.1.
CH473995 Genomic DNA. Translation: EDL78825.1.
RefSeqiNP_001128158.1. NM_001134686.2. [B5D5N9-2]
NP_072141.2. NM_022619.3. [B5D5N9-1]
UniGeneiRn.48707.

Genome annotation databases

EnsembliENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
GeneIDi64554.
KEGGirno:64554.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245001 mRNA. Translation: AAQ14243.1.
AF245002 mRNA. Translation: AAQ14244.1.
CH473995 Genomic DNA. Translation: EDL78824.1.
CH473995 Genomic DNA. Translation: EDL78825.1.
RefSeqiNP_001128158.1. NM_001134686.2. [B5D5N9-2]
NP_072141.2. NM_022619.3. [B5D5N9-1]
UniGeneiRn.48707.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055811.

Proteomic databases

PaxDbiB5D5N9.
PRIDEiB5D5N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
GeneIDi64554.
KEGGirno:64554.

Organism-specific databases

CTDi6542.
RGDi68387. Slc7a2.

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
InParanoidiB5D5N9.
KOiK13864.
PhylomeDBiB5D5N9.

Enzyme and pathway databases

ReactomeiREACT_311758. Amino acid transport across the plasma membrane.

Miscellaneous databases

NextBioi613456.
PROiB5D5N9.

Gene expression databases

ExpressionAtlasiB5D5N9. baseline.
GenevisibleiB5D5N9. RN.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rattus cationic amino acid transporter-2 (rCAT-2) mRNA."
    Cui Z., Kelly J., Brzeski H., Marber M., Pearson J.D., Baydoun A.R.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Wistar.
    Tissue: Aortic smooth muscle.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiCTR2_RAT
AccessioniPrimary (citable) accession number: B5D5N9
Secondary accession number(s): B5D5P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 14, 2008
Last modified: June 24, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.