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Protein

Cationic amino acid transporter 2

Gene

Slc7a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). The affinity for its substrates differs between isoforms created by alternative splicing. May play a role in classical or alternative activation of macrophages via its role in arginine transport.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 2
Short name:
CAT-2
Short name:
CAT2
Alternative name(s):
Low affinity cationic amino acid transporter 2
Solute carrier family 7 member 2
Gene namesi
Name:Slc7a2
Synonyms:Atrc2, Cat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi68387. Slc7a2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 66ExtracellularSequence analysis7
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 104CytoplasmicSequence analysisAdd BLAST17
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 163ExtracellularSequence analysisAdd BLAST38
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 192CytoplasmicSequence analysis8
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 248ExtracellularSequence analysisAdd BLAST35
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 289CytoplasmicSequence analysisAdd BLAST20
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 339ExtracellularSequence analysisAdd BLAST29
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 385CytoplasmicSequence analysisAdd BLAST25
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 409ExtracellularSequence analysis3
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 489CytoplasmicSequence analysisAdd BLAST59
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 523ExtracellularSequence analysisAdd BLAST13
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 554CytoplasmicSequence analysis10
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 581ExtracellularSequence analysis6
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 657CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003752271 – 657Cationic amino acid transporter 2Add BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Modified residuei463PhosphoserineBy similarity1
Modified residuei645PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlasiB5D5N9.
PRIDEiB5D5N9.

PTM databases

iPTMnetiB5D5N9.
PhosphoSitePlusiB5D5N9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011016.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
InParanoidiB5D5N9.
KOiK13864.
OMAiNAAGNLC.
OrthoDBiEOG091G05NM.
PhylomeDBiB5D5N9.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B5D5N9-1) [UniParc]FASTAAdd to basket
Also known as: CAT2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPCRAVLTF TRCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA
60 70 80 90 100
GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY
110 120 130 140 150
LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF
160 170 180 190 200
KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL
210 220 230 240 250
VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM
260 270 280 290 300
PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF
310 320 330 340 350
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS
360 370 380 390 400
TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM
410 420 430 440 450
AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYE QPKYTPEKDI
460 470 480 490 500
LESCTNATSK SESQVTMLQG QGFSLRTLFN PSALPTRQSA SLVSFLVGFL
510 520 530 540 550
AFLIAGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI LTIWRQPQNQ
560 570 580 590 600
QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWVRFSIWM VLGFLIYFAY
610 620 630 640 650
GIRHSLEGNP RDEEEDEDVC PDNVNAAAEE KSAMQANDHH QRNLSLPFIL

HEKTSEC
Length:657
Mass (Da):71,694
Last modified:October 14, 2008 - v1
Checksum:i313E0A05771931B7
GO
Isoform 2 (identifier: B5D5N9-2) [UniParc]FASTAAdd to basket
Also known as: CAT2B

The sequence of this isoform differs from the canonical sequence as follows:
     357-397: MFPLPRILFA...AATMTAGVIS → IFPMPRVIYA...IATLSSGAVA

Show »
Length:658
Mass (Da):71,638
Checksum:iCD5DF2B16FF172A8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037355357 – 397MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPIIATLSSGA VA in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245001 mRNA. Translation: AAQ14243.1.
AF245002 mRNA. Translation: AAQ14244.1.
CH473995 Genomic DNA. Translation: EDL78824.1.
CH473995 Genomic DNA. Translation: EDL78825.1.
RefSeqiNP_001128158.1. NM_001134686.2. [B5D5N9-2]
NP_072141.2. NM_022619.3. [B5D5N9-1]
UniGeneiRn.48707.

Genome annotation databases

EnsembliENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
GeneIDi64554.
KEGGirno:64554.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245001 mRNA. Translation: AAQ14243.1.
AF245002 mRNA. Translation: AAQ14244.1.
CH473995 Genomic DNA. Translation: EDL78824.1.
CH473995 Genomic DNA. Translation: EDL78825.1.
RefSeqiNP_001128158.1. NM_001134686.2. [B5D5N9-2]
NP_072141.2. NM_022619.3. [B5D5N9-1]
UniGeneiRn.48707.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiB5D5N9.
PhosphoSitePlusiB5D5N9.

Proteomic databases

PeptideAtlasiB5D5N9.
PRIDEiB5D5N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016. [B5D5N9-2]
ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016. [B5D5N9-1]
GeneIDi64554.
KEGGirno:64554.

Organism-specific databases

CTDi6542.
RGDi68387. Slc7a2.

Phylogenomic databases

GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
InParanoidiB5D5N9.
KOiK13864.
OMAiNAAGNLC.
OrthoDBiEOG091G05NM.
PhylomeDBiB5D5N9.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiB5D5N9.

Gene expression databases

BgeeiENSRNOG00000011016.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCTR2_RAT
AccessioniPrimary (citable) accession number: B5D5N9
Secondary accession number(s): B5D5P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.