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B5BUQ6

- B5BUQ6_HUMAN

UniProt

B5BUQ6 - B5BUQ6_HUMAN

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Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cell activation Source: Ensembl
  4. cellular extravasation Source: Ensembl
  5. cellular response to amino acid stimulus Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to Gram-positive bacterium Source: Ensembl
  8. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  9. extracellular matrix organization Source: Ensembl
  10. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  11. glucose metabolic process Source: Ensembl
  12. humoral immune response Source: Ensembl
  13. inflammatory response Source: Ensembl
  14. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  15. JNK cascade Source: Ensembl
  16. negative regulation of alkaline phosphatase activity Source: Ensembl
  17. negative regulation of cell proliferation Source: Ensembl
  18. negative regulation of glucose import Source: Ensembl
  19. negative regulation of growth of symbiont in host Source: Ensembl
  20. negative regulation of L-glutamate transport Source: Ensembl
  21. negative regulation of osteoblast differentiation Source: Ensembl
  22. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  23. organ morphogenesis Source: Ensembl
  24. osteoclast differentiation Source: Ensembl
  25. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
  26. positive regulation of fever generation Source: Ensembl
  27. positive regulation of hair follicle development Source: Ensembl
  28. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  30. positive regulation of interferon-gamma production Source: Ensembl
  31. positive regulation of interleukin-18 production Source: Ensembl
  32. positive regulation of interleukin-6 production Source: Ensembl
  33. positive regulation of JNK cascade Source: Ensembl
  34. positive regulation of mitosis Source: Ensembl
  35. positive regulation of neuron apoptotic process Source: Ensembl
  36. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  37. positive regulation of protein kinase B signaling Source: Ensembl
  38. positive regulation of synaptic transmission Source: Ensembl
  39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  40. positive regulation of translational initiation by iron Source: Ensembl
  41. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
  42. regulation of immunoglobulin secretion Source: Ensembl
  43. regulation of osteoclast differentiation Source: Ensembl
  44. regulation of protein phosphorylation Source: Ensembl
  45. regulation of reactive oxygen species metabolic process Source: Ensembl
  46. response to activity Source: Ensembl
  47. response to drug Source: Ensembl
  48. response to hypoxia Source: Ensembl
  49. response to mechanical stimulus Source: Ensembl
  50. skeletal muscle contraction Source: Ensembl
  51. tumor necrosis factor-mediated signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. integral component of membrane Source: Ensembl
  4. membrane raft Source: Ensembl
  5. phagocytic cup Source: Ensembl
  6. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

Expressioni

Gene expression databases

BgeeiB5BUQ6.
ExpressionAtlasiB5BUQ6. baseline and differential.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG012516.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B5BUQ6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV
60 70 80 90 100
PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP
110 120 130 140 150
CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV

YFGIIAL
Length:157
Mass (Da):17,353
Last modified:October 14, 2008 - v1
Checksum:iD134511F90BCCF20
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB451492 mRNA. Translation: BAG70306.1.
UniGeneiHs.241570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB451492 mRNA. Translation: BAG70306.1 .
UniGenei Hs.241570.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG012516.

Miscellaneous databases

ChiTaRSi TNF. human.
NextBioi 35477951.

Gene expression databases

Bgeei B5BUQ6.
ExpressionAtlasi B5BUQ6. baseline and differential.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J.-I., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K.-I., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J.-I., Watanabe S., Nomura N.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB5BUQ6_HUMAN
AccessioniPrimary (citable) accession number: B5BUQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.