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Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiB5BUQ6.
PeptideAtlasiB5BUQ6.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB5BUQ6.
SMRiB5BUQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 157TNF_2InterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Phylogenomic databases

eggNOGiENOG410ISAN. Eukaryota.
ENOG410YQC4. LUCA.
HOVERGENiHBG012516.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
PANTHERiPTHR11471:SF46. PTHR11471:SF46. 1 hit.
PfamiView protein in Pfam
PF00229. TNF. 1 hit.
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

B5BUQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV
60 70 80 90 100
PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP
110 120 130 140 150
CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV

YFGIIAL
Length:157
Mass (Da):17,353
Last modified:October 14, 2008 - v1
Checksum:iD134511F90BCCF20
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB451492 mRNA. Translation: BAG70306.1.
UniGeneiHs.241570.

Similar proteinsi

Entry informationi

Entry nameiB5BUQ6_HUMAN
AccessioniPrimary (citable) accession number: B5BUQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: August 30, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.