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B5BUQ6

- B5BUQ6_HUMAN

UniProt

B5BUQ6 - B5BUQ6_HUMAN

Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cell activation Source: Ensembl
    4. cellular amino acid biosynthetic process Source: Ensembl
    5. cellular extravasation Source: Ensembl
    6. cellular response to amino acid stimulus Source: Ensembl
    7. defense response to Gram-positive bacterium Source: Ensembl
    8. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    9. extracellular matrix organization Source: Ensembl
    10. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    11. glucose metabolic process Source: Ensembl
    12. humoral immune response Source: Ensembl
    13. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    14. JNK cascade Source: Ensembl
    15. negative regulation of alkaline phosphatase activity Source: Ensembl
    16. negative regulation of cell proliferation Source: Ensembl
    17. negative regulation of glucose import Source: Ensembl
    18. negative regulation of growth of symbiont in host Source: Ensembl
    19. negative regulation of L-glutamate transport Source: Ensembl
    20. negative regulation of osteoblast differentiation Source: Ensembl
    21. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    22. organ morphogenesis Source: Ensembl
    23. osteoclast differentiation Source: Ensembl
    24. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
    25. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    26. positive regulation of fever generation Source: Ensembl
    27. positive regulation of hair follicle development Source: Ensembl
    28. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
    29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    30. positive regulation of interferon-gamma production Source: Ensembl
    31. positive regulation of interleukin-18 production Source: Ensembl
    32. positive regulation of interleukin-6 production Source: Ensembl
    33. positive regulation of JNK cascade Source: Ensembl
    34. positive regulation of mitosis Source: Ensembl
    35. positive regulation of neuron apoptotic process Source: Ensembl
    36. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    37. positive regulation of protein kinase B signaling Source: Ensembl
    38. positive regulation of synaptic transmission Source: Ensembl
    39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    40. positive regulation of translational initiation by iron Source: Ensembl
    41. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
    42. regulation of immunoglobulin secretion Source: Ensembl
    43. regulation of osteoclast differentiation Source: Ensembl
    44. regulation of protein phosphorylation Source: Ensembl
    45. response to activity Source: Ensembl
    46. response to drug Source: Ensembl
    47. response to hypoxia Source: Ensembl
    48. response to mechanical stimulus Source: Ensembl
    49. skeletal muscle contraction Source: Ensembl
    50. tumor necrosis factor-mediated signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    CytokineSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tumor necrosis factor alphaImported
    Gene namesi
    Name:TNFImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. integral component of membrane Source: Ensembl
    4. membrane raft Source: Ensembl
    5. phagocytic cup Source: Ensembl
    6. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    MembraneSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiB5BUQ6.
    BgeeiB5BUQ6.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG012516.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B5BUQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV    50
    PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP 100
    CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV 150
    YFGIIAL 157
    Length:157
    Mass (Da):17,353
    Last modified:October 14, 2008 - v1
    Checksum:iD134511F90BCCF20
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB451492 mRNA. Translation: BAG70306.1.
    UniGeneiHs.241570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB451492 mRNA. Translation: BAG70306.1 .
    UniGenei Hs.241570.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG012516.

    Miscellaneous databases

    ChiTaRSi TNF. human.
    NextBioi 35477951.

    Gene expression databases

    ArrayExpressi B5BUQ6.
    Bgeei B5BUQ6.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J.-I., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K.-I., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J.-I., Watanabe S., Nomura N.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiB5BUQ6_HUMAN
    AccessioniPrimary (citable) accession number: B5BUQ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 14, 2008
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.