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B5BL50 (B5BL50_SALPK) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain HAMAP-Rule MF_01209
EC=6.3.5.5 HAMAP-Rule MF_01209
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain HAMAP-Rule MF_01209
Gene names
Name:carA HAMAP-Rule MF_01209
Ordered Locus Names:SSPA0063 EMBL CAR58174.1
OrganismSalmonella paratyphi A (strain AKU_12601) [Complete proteome] [HAMAP] EMBL CAR58174.1
Taxonomic identifier554290 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP-Rule MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP-Rule MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP-Rule MF_01209 SAAS SAAS006274

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. HAMAP-Rule MF_01209

Sequence similarities

Belongs to the CarA family. HAMAP-Rule MF_01209

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_01209

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain193 – 380188Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_01209
Region1 – 189189CPSase By similarity HAMAP-Rule MF_01209

Sites

Active site2691Nucleophile By similarity HAMAP-Rule MF_01209
Active site3531 By similarity HAMAP-Rule MF_01209
Active site3551 By similarity HAMAP-Rule MF_01209

Sequences

Sequence LengthMass (Da)Tools
B5BL50 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: A2AA8EF996672061

FASTA38241,696
        10         20         30         40         50         60 
MIKSALLVLE DGTQFHGRAI GATGSAVGEV VFNTSMTGYQ EILTDPSYSR QIVTLTYPHI 

        70         80         90        100        110        120 
GNVGTNEADE ESSQVHAQGL VIRDLPLIAS NFRNTEDLSS YLKRHNIVAI ADIDTRKLTR 

       130        140        150        160        170        180 
LLREKGAQNG CIIAGDSPDA KLALEKAKAF PGLNGMDLAK EVTTTETYRW TQGSWTLKDG 

       190        200        210        220        230        240 
LPEAKSEDDL PFHVVAYDFG AKRNILRMLV DRGCRLTVVP AQTSAEEVLK MNPDGIFLSN 

       250        260        270        280        290        300 
GPGDPAPCDY AIEAIEKFLQ TDIPVFGICL GHQLLALASG AKTVKMKFGH HGGNHPVKDM 

       310        320        330        340        350        360 
DRNVVMITAQ NHGFAVDEDS LPANLRVTHK SLFDGTLQGI HRTDKPAFSF QGHPEASPGP 

       370        380 
HDAAPLFDHF IELIEQYRQS AK

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References

[1]"Complete genome of a clinical isolate of Salmonella enterica serovar Paratyphi A."
Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hassan R., Bhutta Z., Quail M., Norbertczak H., Danielle W., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AKU_12601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM200053 Genomic DNA. Translation: CAR58174.1.
RefSeqYP_002140910.1. NC_011147.1.

3D structure databases

ProteinModelPortalB5BL50.
SMRB5BL50. Positions 2-381.
ModBaseSearch...

Protein-protein interaction databases

STRING554290.SSPA0063.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR58174; CAR58174; SSPA0063.
GeneID6809342.
KEGGsek:SSPA0063.
PATRIC32339604. VBISalEnt134303_0071.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0505.
HOGENOMHOG000038087.
KOK01956.
OMARDSHYLF.
ProtClustDBPRK12564.

Enzyme and pathway databases

BioCycSENT554290:GJDA-67-MONOMER.
UniPathwayUPA00068; UER00171.
UPA00070; UER00115.

Family and domain databases

Gene3D3.50.30.20. 1 hit.
HAMAPMF_01209. CPSase_S_chain.
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5BL50_SALPK
AccessionPrimary (citable) accession number: B5BL50
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info