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B5BJG9

- RHAR_SALPK

UniProt

B5BJG9 - RHAR_SALPK

Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei246 – 2461Interaction with sigma-70UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi195 – 21420H-T-H motifUniRule annotationAdd
    BLAST
    DNA bindingi244 – 26724H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    2. rhamnose metabolic process Source: UniProtKB-HAMAP
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Rhamnose metabolism, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciSENT554290:GJDA-3899-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional activator RhaRUniRule annotation
    Alternative name(s):
    L-rhamnose operon transcriptional activator RhaRUniRule annotation
    Gene namesi
    Name:rhaRUniRule annotation
    Ordered Locus Names:SSPA3620
    OrganismiSalmonella paratyphi A (strain AKU_12601)
    Taxonomic identifieri554290 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001869: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282HTH-type transcriptional activator RhaRPRO_1000200943Add
    BLAST

    Proteomic databases

    PRIDEiB5BJG9.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi554290.SSPA3620.

    Structurei

    3D structure databases

    ProteinModelPortaliB5BJG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2207.
    HOGENOMiHOG000290513.
    OMAiLQTEDYF.
    OrthoDBiEOG6Z3KH4.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    2.60.120.280. 1 hit.
    HAMAPiMF_01533. HTH_type_RhaR.
    InterProiIPR003313. AraC-bd.
    IPR009057. Homeodomain-like.
    IPR018060. HTH_AraC.
    IPR018062. HTH_AraC-typ_CS.
    IPR011051. RmlC_Cupin.
    IPR023699. Tscrpt_act_RhaR.
    IPR020449. Tscrpt_reg_HTH_AraC-type.
    [Graphical view]
    PfamiPF02311. AraC_binding. 1 hit.
    PF12833. HTH_18. 1 hit.
    [Graphical view]
    PRINTSiPR00032. HTHARAC.
    SMARTiSM00342. HTH_ARAC. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF51182. SSF51182. 1 hit.
    PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
    PS01124. HTH_ARAC_FAMILY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5BJG9-1 [UniParc]FASTAAdd to Basket

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    MANQLILLKK DFFTDEQQAV TVADRYPQDV FAEHTHEFCE LVMVWRGNGL    50
    HVLNERPYRI TRGDLFYIRA EDKHSYTSVN DLVLQNIIYC PERLKLNVNW 100
    QAMIPGFQGA QWHPHWRLGS MGMNQARQVI NQLEHESNGR DPLANEMAEL 150
    LFGQLVMTLK RHRYATDDLP ATSRETLLDK LITALANSLE CPFALDAFCQ 200
    QEQCSERVLR QQFRAQTGMT INQYLRQVRI CHAQYLLQHS PLMISEISMQ 250
    CGFEDSNYFS VVFTRETGMT PSQWRHLSNQ SD 282
    Length:282
    Mass (Da):32,858
    Last modified:September 23, 2008 - v1
    Checksum:i657BF8FE7DE1CF20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR61902.1.
    RefSeqiYP_002144461.1. NC_011147.1.

    Genome annotation databases

    EnsemblBacteriaiCAR61902; CAR61902; SSPA3620.
    PATRICi32347932. VBISalEnt134303_4139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR61902.1 .
    RefSeqi YP_002144461.1. NC_011147.1.

    3D structure databases

    ProteinModelPortali B5BJG9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 554290.SSPA3620.

    Protein family/group databases

    AraC-XylS Search...

    Proteomic databases

    PRIDEi B5BJG9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR61902 ; CAR61902 ; SSPA3620 .
    PATRICi 32347932. VBISalEnt134303_4139.

    Phylogenomic databases

    eggNOGi COG2207.
    HOGENOMi HOG000290513.
    OMAi LQTEDYF.
    OrthoDBi EOG6Z3KH4.

    Enzyme and pathway databases

    BioCyci SENT554290:GJDA-3899-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    2.60.120.280. 1 hit.
    HAMAPi MF_01533. HTH_type_RhaR.
    InterProi IPR003313. AraC-bd.
    IPR009057. Homeodomain-like.
    IPR018060. HTH_AraC.
    IPR018062. HTH_AraC-typ_CS.
    IPR011051. RmlC_Cupin.
    IPR023699. Tscrpt_act_RhaR.
    IPR020449. Tscrpt_reg_HTH_AraC-type.
    [Graphical view ]
    Pfami PF02311. AraC_binding. 1 hit.
    PF12833. HTH_18. 1 hit.
    [Graphical view ]
    PRINTSi PR00032. HTHARAC.
    SMARTi SM00342. HTH_ARAC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF51182. SSF51182. 1 hit.
    PROSITEi PS00041. HTH_ARAC_FAMILY_1. 1 hit.
    PS01124. HTH_ARAC_FAMILY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
      Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
      BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AKU_12601.

    Entry informationi

    Entry nameiRHAR_SALPK
    AccessioniPrimary (citable) accession number: B5BJG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3