B5BJG9 (RHAR_SALPK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional activator RhaR

Alternative name(s):
L-rhamnose operon transcriptional activator RhaR

Gene names

Name:	rhaR
Ordered Locus Names:	SSPA3620

Organism

Salmonella paratyphi A (strain AKU_12601) [Complete proteome] [HAMAP]

Taxonomic identifier

554290 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella paratyphi A

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates expression of the rhaSR operon in response to L-rhamnose By similarity. HAMAP-Rule MF_01533
Subunit structure	Binds DNA as a dimer By similarity. HAMAP-Rule MF_01533
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01533.
Sequence similarities	Contains 2 HTH araC/xylS-type DNA-binding domains.

Ontologies

Keywords
Biological process	Rhamnose metabolism Transcription Transcription regulation
Cellular component	Cytoplasm
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP rhamnose metabolic process Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	HTH-type transcriptional activator RhaR HAMAP-Rule MF_01533		PRO_1000200943
Regions
	DNA binding	195 – 214	20	H-T-H motif By similarity
	DNA binding	244 – 267	24	H-T-H motif By similarity
Sites
	Site	246	1	Interaction with sigma-70 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5BJG9 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 657BF8FE7DE1CF20	FASTA	282	32,858
	10 20 30 40 50 60 MANQLILLKK DFFTDEQQAV TVADRYPQDV FAEHTHEFCE LVMVWRGNGL HVLNERPYRI 70 80 90 100 110 120 TRGDLFYIRA EDKHSYTSVN DLVLQNIIYC PERLKLNVNW QAMIPGFQGA QWHPHWRLGS 130 140 150 160 170 180 MGMNQARQVI NQLEHESNGR DPLANEMAEL LFGQLVMTLK RHRYATDDLP ATSRETLLDK 190 200 210 220 230 240 LITALANSLE CPFALDAFCQ QEQCSERVLR QQFRAQTGMT INQYLRQVRI CHAQYLLQHS 250 260 270 280 PLMISEISMQ CGFEDSNYFS VVFTRETGMT PSQWRHLSNQ SD

References

[1]

"Complete genome of a clinical isolate of Salmonella enterica serovar Paratyphi A." Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hassan R., Bhutta Z., Quail M., Norbertczak H., Danielle W., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AKU_12601.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM200053 Genomic DNA. Translation: CAR61902.1.
RefSeq	YP_002144461.1. NC_011147.1.
3D structure databases
ProteinModelPortal	B5BJG9.
ModBase	Search...
Protein-protein interaction databases
STRING	554290.SSPA3620.
Protein family/group databases
AraC-XylS	Search...
Proteomic databases
PRIDE	B5BJG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAR61902; CAR61902; SSPA3620.
GeneID	6812971.
KEGG	sek:SSPA3620.
PATRIC	32347932. VBISalEnt134303_4139.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2207.
HOGENOM	HOG000290513.
KO	K02854.
OMA	DEFCDEA.
ProtClustDB	PRK13502.
Enzyme and pathway databases
BioCyc	SENT554290:GJDA-3899-MONOMER.
Family and domain databases
Gene3D	1.10.10.60. 2 hits. 2.60.120.280. 1 hit.
HAMAP	MF_01533. HTH-type_RhaR.
InterPro	IPR009057. Homeodomain-like. IPR018060. HTH_AraC. IPR018062. HTH_AraC-typ_CS. IPR011051. RmlC_Cupin. IPR023699. Tscrpt_act_RhaR. IPR003313. Tscrpt_reg_HTH_AraC-bd. IPR020449. Tscrpt_reg_HTH_AraC-type. [Graphical view]
Pfam	PF02311. AraC_binding. 1 hit. PF12833. HTH_18. 1 hit. [Graphical view]
PRINTS	PR00032. HTHARAC.
SMART	SM00342. HTH_ARAC. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits. SSF51182. RmlC_like_cupin. 1 hit.
PROSITE	PS00041. HTH_ARAC_FAMILY_1. 1 hit. PS01124. HTH_ARAC_FAMILY_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RHAR_SALPK

Accession

Primary (citable) accession number: B5BJG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	May 29, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program