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Protein

HTH-type transcriptional activator RhaR

Gene

rhaR

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates expression of the rhaSR operon in response to L-rhamnose.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei246 – 2461Interaction with sigma-70UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi195 – 21420H-T-H motifUniRule annotationAdd
BLAST
DNA bindingi244 – 26724H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. rhamnose metabolic process Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSENT554290:GJDA-3899-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaRUniRule annotation
Alternative name(s):
L-rhamnose operon transcriptional activator RhaRUniRule annotation
Gene namesi
Name:rhaRUniRule annotation
Ordered Locus Names:SSPA3620
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001869 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282HTH-type transcriptional activator RhaRPRO_1000200943Add
BLAST

Proteomic databases

PRIDEiB5BJG9.

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Protein-protein interaction databases

STRINGi554290.SSPA3620.

Structurei

3D structure databases

ProteinModelPortaliB5BJG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2207.
HOGENOMiHOG000290513.
OMAiLQTEDYF.
OrthoDBiEOG6Z3KH4.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01533. HTH_type_RhaR.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5BJG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQLILLKK DFFTDEQQAV TVADRYPQDV FAEHTHEFCE LVMVWRGNGL
60 70 80 90 100
HVLNERPYRI TRGDLFYIRA EDKHSYTSVN DLVLQNIIYC PERLKLNVNW
110 120 130 140 150
QAMIPGFQGA QWHPHWRLGS MGMNQARQVI NQLEHESNGR DPLANEMAEL
160 170 180 190 200
LFGQLVMTLK RHRYATDDLP ATSRETLLDK LITALANSLE CPFALDAFCQ
210 220 230 240 250
QEQCSERVLR QQFRAQTGMT INQYLRQVRI CHAQYLLQHS PLMISEISMQ
260 270 280
CGFEDSNYFS VVFTRETGMT PSQWRHLSNQ SD
Length:282
Mass (Da):32,858
Last modified:September 23, 2008 - v1
Checksum:i657BF8FE7DE1CF20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR61902.1.
RefSeqiYP_002144461.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR61902; CAR61902; SSPA3620.
PATRICi32347932. VBISalEnt134303_4139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR61902.1.
RefSeqiYP_002144461.1. NC_011147.1.

3D structure databases

ProteinModelPortaliB5BJG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi554290.SSPA3620.

Protein family/group databases

AraC-XylSSearch...

Proteomic databases

PRIDEiB5BJG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR61902; CAR61902; SSPA3620.
PATRICi32347932. VBISalEnt134303_4139.

Phylogenomic databases

eggNOGiCOG2207.
HOGENOMiHOG000290513.
OMAiLQTEDYF.
OrthoDBiEOG6Z3KH4.

Enzyme and pathway databases

BioCyciSENT554290:GJDA-3899-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01533. HTH_type_RhaR.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR011051. RmlC_Cupin.
IPR023699. Tscrpt_act_RhaR.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
    Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
    BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AKU_12601.

Entry informationi

Entry nameiRHAR_SALPK
AccessioniPrimary (citable) accession number: B5BJG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.