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B5BI54 (EMTA_SALPK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endo-type membrane-bound lytic murein transglycosylase A

EC=4.2.2.n2
Alternative name(s):
Peptidoglycan lytic endotransglycosylase
Gene names
Name:emtA
Ordered Locus Names:SSPA1003
OrganismSalmonella paratyphi A (strain AKU_12601) [Complete proteome] [HAMAP]
Taxonomic identifier554290 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain By similarity. HAMAP-Rule MF_01381

Catalytic activity

Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. HAMAP-Rule MF_01381

Subcellular location

Cell outer membrane; Lipid-anchor Potential HAMAP-Rule MF_01381.

Sequence similarities

Belongs to the transglycosylase Slt family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 203188Endo-type membrane-bound lytic murein transglycosylase A HAMAP-Rule MF_01381
PRO_1000144960

Amino acid modifications

Lipidation161N-palmitoyl cysteine Potential
Lipidation161S-diacylglycerol cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
B5BI54 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 1E0C787444FD5D1D

FASTA20322,427
        10         20         30         40         50         60 
MKLRWFAFLV VILAGCSSKQ DYRNPPWNAE VPVKRAMQWM PISEKAGAAW GVDPHLITAI 

        70         80         90        100        110        120 
IAIESGGNPN AVSKSNAIGL MQLKASTSGR DVYRRMGWRG EPTTSELKNP ERNISMGAAY 

       130        140        150        160        170        180 
LSILENGPLA GIKDPQVMQY ALVVSYANGA GALLRTFSSD RKKAIEKIND LDADEFFEHV 

       190        200 
VDNHPAPQAP RYIWKLQQAL DAM 

« Hide

References

[1]"Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AKU_12601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM200053 Genomic DNA. Translation: CAR59154.1.
RefSeqYP_002141844.1. NC_011147.1.

3D structure databases

ProteinModelPortalB5BI54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING554290.SSPA1003.

Protein family/group databases

CAZyGH23. Glycoside Hydrolase Family 23.

Proteomic databases

PRIDEB5BI54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR59154; CAR59154; SSPA1003.
PATRIC32341803. VBISalEnt134303_1144.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0741.
HOGENOMHOG000219318.
OMAPQAPRYL.
OrthoDBEOG6Z0Q66.

Enzyme and pathway databases

BioCycSENT554290:GJDA-1063-MONOMER.

Family and domain databases

HAMAPMF_01381. EmtA.
InterProIPR023946. EmtA.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
IPR000189. Transglyc_AS.
[Graphical view]
PfamPF01464. SLT. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEMTA_SALPK
AccessionPrimary (citable) accession number: B5BI54
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families