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B5BI54

- EMTA_SALPK

UniProt

B5BI54 - EMTA_SALPK

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Protein

Endo-type membrane-bound lytic murein transglycosylase A

Gene

emtA

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.UniRule annotation

Catalytic activityi

Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

  1. carbon-oxygen lyase activity, acting on polysaccharides Source: UniProtKB-HAMAP
  2. lytic endotransglycosylase activity Source: InterPro

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: UniProtKB-HAMAP
  2. cell wall organization Source: UniProtKB-KW
  3. peptidoglycan metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciSENT554290:GJDA-1063-MONOMER.

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-type membrane-bound lytic murein transglycosylase AUniRule annotation (EC:4.2.2.n2UniRule annotation)
Alternative name(s):
Peptidoglycan lytic endotransglycosylaseUniRule annotation
Gene namesi
Name:emtAUniRule annotation
Ordered Locus Names:SSPA1003
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001869: Chromosome

Subcellular locationi

Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515UniRule annotationAdd
BLAST
Chaini16 – 203188Endo-type membrane-bound lytic murein transglycosylase APRO_1000144960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi16 – 161N-palmitoyl cysteineUniRule annotation
Lipidationi16 – 161S-diacylglycerol cysteineUniRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiB5BI54.

Interactioni

Protein-protein interaction databases

STRINGi554290.SSPA1003.

Structurei

3D structure databases

ProteinModelPortaliB5BI54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0741.
HOGENOMiHOG000219318.
OMAiPQAPRYL.
OrthoDBiEOG6Z0Q66.

Family and domain databases

HAMAPiMF_01381. EmtA.
InterProiIPR023946. EmtA.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
IPR000189. Transglyc_AS.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5BI54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLRWFAFLV VILAGCSSKQ DYRNPPWNAE VPVKRAMQWM PISEKAGAAW
60 70 80 90 100
GVDPHLITAI IAIESGGNPN AVSKSNAIGL MQLKASTSGR DVYRRMGWRG
110 120 130 140 150
EPTTSELKNP ERNISMGAAY LSILENGPLA GIKDPQVMQY ALVVSYANGA
160 170 180 190 200
GALLRTFSSD RKKAIEKIND LDADEFFEHV VDNHPAPQAP RYIWKLQQAL

DAM
Length:203
Mass (Da):22,427
Last modified:September 23, 2008 - v1
Checksum:i1E0C787444FD5D1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM200053 Genomic DNA. Translation: CAR59154.1.
RefSeqiYP_002141844.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR59154; CAR59154; SSPA1003.
PATRICi32341803. VBISalEnt134303_1144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM200053 Genomic DNA. Translation: CAR59154.1 .
RefSeqi YP_002141844.1. NC_011147.1.

3D structure databases

ProteinModelPortali B5BI54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 554290.SSPA1003.

Protein family/group databases

CAZyi GH23. Glycoside Hydrolase Family 23.

Proteomic databases

PRIDEi B5BI54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR59154 ; CAR59154 ; SSPA1003 .
PATRICi 32341803. VBISalEnt134303_1144.

Phylogenomic databases

eggNOGi COG0741.
HOGENOMi HOG000219318.
OMAi PQAPRYL.
OrthoDBi EOG6Z0Q66.

Enzyme and pathway databases

BioCyci SENT554290:GJDA-1063-MONOMER.

Family and domain databases

HAMAPi MF_01381. EmtA.
InterProi IPR023946. EmtA.
IPR023346. Lysozyme-like_dom.
IPR008258. TGlycosylase-like_SLT.
IPR000189. Transglyc_AS.
[Graphical view ]
Pfami PF01464. SLT. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
    Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
    BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AKU_12601.

Entry informationi

Entry nameiEMTA_SALPK
AccessioniPrimary (citable) accession number: B5BI54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3