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Protein

Endo-type membrane-bound lytic murein transglycosylase A

Gene

emtA

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.UniRule annotation

Catalytic activityi

Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-type membrane-bound lytic murein transglycosylase AUniRule annotation (EC:4.2.2.n2UniRule annotation)
Alternative name(s):
Peptidoglycan lytic endotransglycosylaseUniRule annotation
Gene namesi
Name:emtAUniRule annotation
Ordered Locus Names:SSPA1003
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15UniRule annotationAdd BLAST15
ChainiPRO_100014496016 – 203Endo-type membrane-bound lytic murein transglycosylase AAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi16N-palmitoyl cysteineUniRule annotation1
Lipidationi16S-diacylglycerol cysteineUniRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliB5BI54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000219318.
KOiK08308.
OMAiPQAPRYL.

Family and domain databases

HAMAPiMF_01381. EmtA. 1 hit.
InterProiIPR023946. EmtA.
IPR023346. Lysozyme-like_dom.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5BI54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRWFAFLV VILAGCSSKQ DYRNPPWNAE VPVKRAMQWM PISEKAGAAW
60 70 80 90 100
GVDPHLITAI IAIESGGNPN AVSKSNAIGL MQLKASTSGR DVYRRMGWRG
110 120 130 140 150
EPTTSELKNP ERNISMGAAY LSILENGPLA GIKDPQVMQY ALVVSYANGA
160 170 180 190 200
GALLRTFSSD RKKAIEKIND LDADEFFEHV VDNHPAPQAP RYIWKLQQAL

DAM
Length:203
Mass (Da):22,427
Last modified:September 23, 2008 - v1
Checksum:i1E0C787444FD5D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR59154.1.
RefSeqiWP_000776974.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR59154; CAR59154; SSPA1003.
KEGGisek:SSPA1003.
PATRICi32341803. VBISalEnt134303_1144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR59154.1.
RefSeqiWP_000776974.1. NC_011147.1.

3D structure databases

ProteinModelPortaliB5BI54.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR59154; CAR59154; SSPA1003.
KEGGisek:SSPA1003.
PATRICi32341803. VBISalEnt134303_1144.

Phylogenomic databases

HOGENOMiHOG000219318.
KOiK08308.
OMAiPQAPRYL.

Family and domain databases

HAMAPiMF_01381. EmtA. 1 hit.
InterProiIPR023946. EmtA.
IPR023346. Lysozyme-like_dom.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMTA_SALPK
AccessioniPrimary (citable) accession number: B5BI54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.