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B5BGB4

- DCYD_SALPK

UniProt

B5BGB4 - DCYD_SALPK

Protein

D-cysteine desulfhydrase

Gene

dcyD

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.UniRule annotation

    Catalytic activityi

    D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-amino acid metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSENT554290:GJDA-906-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-cysteine desulfhydraseUniRule annotation (EC:4.4.1.15UniRule annotation)
    Gene namesi
    Name:dcyDUniRule annotation
    Ordered Locus Names:SSPA0854
    OrganismiSalmonella paratyphi A (strain AKU_12601)
    Taxonomic identifieri554290 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001869: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328D-cysteine desulfhydrasePRO_1000136171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi554290.SSPA0854.

    Structurei

    3D structure databases

    ProteinModelPortaliB5BGB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2515.
    HOGENOMiHOG000022459.
    OMAiIMAQSFE.
    OrthoDBiEOG6FBX0P.

    Family and domain databases

    HAMAPiMF_01045. D_Cys_desulfhydr.
    InterProiIPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5BGB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLHHLTRFP RLELIGAPTP LEYLPRLSDY PGREIYIKRD DVTPIAMGGN    50
    KLRKLEFLVA DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE 100
    NPIGTTAENY LTNGNRLLLD LFNTQIEMCD VLTDPDAQLQ TLATRIEAQG 150
    FRPYVIPVGG SSALGAMGYV ESALEIAQQC EEVVGLSSVV VASGSAGTHA 200
    GLAVGLEHLM PDVELIGVTV SRSVAEQKPK VIALQQAIAG QLALTATADI 250
    HLWDDYFAPG YGVPNDAGME AVKLLASLEG VLLDPVYTGK AMAGLIDGIS 300
    QKRFNDDGPI LFIHTGGAPA LFAYHPHV 328
    Length:328
    Mass (Da):34,889
    Last modified:September 23, 2008 - v1
    Checksum:iEECC42CC46B5F25D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR58997.1.
    RefSeqiYP_002141695.1. NC_011147.1.

    Genome annotation databases

    EnsemblBacteriaiCAR58997; CAR58997; SSPA0854.
    PATRICi32341443. VBISalEnt134303_0967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR58997.1 .
    RefSeqi YP_002141695.1. NC_011147.1.

    3D structure databases

    ProteinModelPortali B5BGB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 554290.SSPA0854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR58997 ; CAR58997 ; SSPA0854 .
    PATRICi 32341443. VBISalEnt134303_0967.

    Phylogenomic databases

    eggNOGi COG2515.
    HOGENOMi HOG000022459.
    OMAi IMAQSFE.
    OrthoDBi EOG6FBX0P.

    Enzyme and pathway databases

    BioCyci SENT554290:GJDA-906-MONOMER.

    Family and domain databases

    HAMAPi MF_01045. D_Cys_desulfhydr.
    InterProi IPR027278. ACCD_DCysDesulf.
    IPR005966. D-Cys_desShydrase.
    IPR023702. D_Cys_desulphydr_bac.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
      Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
      BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AKU_12601.

    Entry informationi

    Entry nameiDCYD_SALPK
    AccessioniPrimary (citable) accession number: B5BGB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3