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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:SSPA0784
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001337471 – 379Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST379

Structurei

3D structure databases

ProteinModelPortaliB5BG44
SMRiB5BG44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

B5BG44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELSFDAPV WRHGKALRKG YTTGSCATAA AKVAALMVLR QHLIHQVSIV
60 70 80 90 100
TPSGVTLCLN VESPHIEGQQ AIAAIRKDGG DDVDATHGML IFARVTLNDS
110 120 130 140 150
GEITLTGGEG IGTVTRKGVG LPLGSAAINR TPRHTIESAV REAIGPARGA
160 170 180 190 200
DVEIFAPEGE VRAQKTYNSR LGILGGISII GTTGIVTPMS EESWKRSLSL
210 220 230 240 250
ELEIKRASGL TRVILVPGNH GERFVREQMG VDTQAVVTMS NFVGYMIEEA
260 270 280 290 300
VRLGFCQIVL VGHPGKLIKI AAGIFHTHSH IADARMETLV AHLALLGAPL
310 320 330 340 350
ELLTLVGDCD TTEAAMEHIE AYGFGHIYNH LARRICLRVM QMRRFTKTPP
360 370
VCDAILFSFD NHILGSNRPV DEIAKELQC
Length:379
Mass (Da):40,846
Last modified:September 23, 2008 - v1
Checksum:i4F1A0025D93DF824
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA Translation: CAR58925.1
RefSeqiWP_001292919.1, NC_011147.1

Genome annotation databases

EnsemblBacteriaiCAR58925; CAR58925; SSPA0784
KEGGisek:SSPA0784

Similar proteinsi

Entry informationi

Entry nameiCBID_SALPK
AccessioniPrimary (citable) accession number: B5BG44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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