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Protein

Probable lipid kinase YegS

Gene

yegS

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably phosphorylates lipids; the in vivo substrate is unknown.UniRule annotation

Cofactori

Mg2+UniRule annotation, Ca2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. Ca2+ may be able to substitute.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401ATPUniRule annotation
Binding sitei95 – 951ATPUniRule annotation
Metal bindingi215 – 2151Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi218 – 2181MagnesiumUniRule annotation
Metal bindingi220 – 2201Magnesium; via carbonyl oxygenUniRule annotation
Active sitei271 – 2711Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 727ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT554290:GJDA-706-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipid kinase YegSUniRule annotation (EC:2.7.1.-UniRule annotation)
Gene namesi
Name:yegSUniRule annotation
Ordered Locus Names:SSPA0671
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Probable lipid kinase YegSPRO_1000144877Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB5BF43.
SMRiB5BF43. Positions 1-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 133132DAGKcUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.UniRule annotation
Contains 1 DAGKc domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261396.
OMAiHWQGDLL.
OrthoDBiEOG613098.

Family and domain databases

HAMAPiMF_01377. YegS.
InterProiIPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR022433. Lip_kinase_YegS.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR03702. lip_kinase_YegS. 1 hit.
TIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5BF43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFPASLLI LNGKSADNQP LREAITLLRD EGIQIHVRVT WEKGDAQRYV
60 70 80 90 100
DEARRLGVET VIAGGGDGTI NEVSTALIQI RDGVAPALGL LPLGTANDFA
110 120 130 140 150
TSAGIPEALD KALKLAIAGN AMEIDMARVN DKTCFINMAT GGFGTRITTE
160 170 180 190 200
TPEKLKAALG GVSYLIHGLM RMDTLTPDRC EIRGENFHWQ GDALVIGIGN
210 220 230 240 250
GRQAGGGQQL CPTALVNDGL LQLRIFTGEE LLPALFSTLT QSDDNPNIID
260 270 280 290
GASAWFDIHA PHEITFNLDG EPLSGQEFHI EVLPGALRCR LPPDCPLLR
Length:299
Mass (Da):32,040
Last modified:September 23, 2008 - v1
Checksum:i7F0EF588A795DD9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR58802.1.
RefSeqiWP_001273395.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR58802; CAR58802; SSPA0671.
KEGGisek:SSPA0671.
PATRICi32341003. VBISalEnt134303_0754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR58802.1.
RefSeqiWP_001273395.1. NC_011147.1.

3D structure databases

ProteinModelPortaliB5BF43.
SMRiB5BF43. Positions 1-299.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR58802; CAR58802; SSPA0671.
KEGGisek:SSPA0671.
PATRICi32341003. VBISalEnt134303_0754.

Phylogenomic databases

HOGENOMiHOG000261396.
OMAiHWQGDLL.
OrthoDBiEOG613098.

Enzyme and pathway databases

BioCyciSENT554290:GJDA-706-MONOMER.

Family and domain databases

HAMAPiMF_01377. YegS.
InterProiIPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR022433. Lip_kinase_YegS.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR03702. lip_kinase_YegS. 1 hit.
TIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
    Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
    BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AKU_12601.

Entry informationi

Entry nameiYEGS_SALPK
AccessioniPrimary (citable) accession number: B5BF43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.