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B5BE92

- TRMD_SALPK

UniProt

B5BE92 - TRMD_SALPK

Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei113 – 1131S-adenosyl-L-methionine; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSENT554290:GJDA-2536-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
    Alternative name(s):
    M1G-methyltransferaseUniRule annotation
    tRNA [GM37] methyltransferaseUniRule annotation
    Gene namesi
    Name:trmDUniRule annotation
    Ordered Locus Names:SSPA2358
    OrganismiSalmonella paratyphi A (strain AKU_12601)
    Taxonomic identifieri554290 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001869: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255tRNA (guanine-N(1)-)-methyltransferasePRO_1000130206Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi554290.SSPA2358.

    Structurei

    3D structure databases

    ProteinModelPortaliB5BE92.
    SMRiB5BE92. Positions 1-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 1386S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RNA methyltransferase TrmD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0336.
    HOGENOMiHOG000016242.
    OMAiFVAGRYE.
    OrthoDBiEOG6J48RZ.

    Family and domain databases

    Gene3Di1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPiMF_00605. TrmD.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view]
    PfamiPF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMiSSF75217. SSF75217. 1 hit.
    TIGRFAMsiTIGR00088. trmD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5BE92-1 [UniParc]FASTAAdd to Basket

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    MFIGIVSLFP EMFRAITDYG VTGRAVKKGL LNIQSWSPRD FAHDRHRTVD    50
    DRPYGGGPGM LMMVQPLRDA IHAAKAAAGE GAKVIYLSPQ GRKLDQAGVS 100
    ELATNQKLIL VCGRYEGVDE RVIQAEIDEE WSIGDYVLSG GELPAMTLID 150
    SVARFIPGVL GHEASAIEDS FADGLLDCPH YTRPEVLEGM EVPPVLLSGN 200
    HAEIRRWRLK QSLGRTWLRR PELLENLALT EEQARLLAEF KTEHAQQQHK 250
    HDGMA 255
    Length:255
    Mass (Da):28,318
    Last modified:September 23, 2008 - v1
    Checksum:iB96812A32091495F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR60589.1.
    RefSeqiYP_002143203.1. NC_011147.1.

    Genome annotation databases

    EnsemblBacteriaiCAR60589; CAR60589; SSPA2358.
    PATRICi32344976. VBISalEnt134303_2698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR60589.1 .
    RefSeqi YP_002143203.1. NC_011147.1.

    3D structure databases

    ProteinModelPortali B5BE92.
    SMRi B5BE92. Positions 1-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 554290.SSPA2358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR60589 ; CAR60589 ; SSPA2358 .
    PATRICi 32344976. VBISalEnt134303_2698.

    Phylogenomic databases

    eggNOGi COG0336.
    HOGENOMi HOG000016242.
    OMAi FVAGRYE.
    OrthoDBi EOG6J48RZ.

    Enzyme and pathway databases

    BioCyci SENT554290:GJDA-2536-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPi MF_00605. TrmD.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view ]
    Pfami PF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMi SSF75217. SSF75217. 1 hit.
    TIGRFAMsi TIGR00088. trmD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
      Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
      BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AKU_12601.

    Entry informationi

    Entry nameiTRMD_SALPK
    AccessioniPrimary (citable) accession number: B5BE92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3