Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B5BD84 (TIG_SALPK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trigger factor

Short name=TF
EC=5.2.1.8
Alternative name(s):
PPIase
Gene names
Name:tig
Ordered Locus Names:SSPA2117
OrganismSalmonella paratyphi A (strain AKU_12601) [Complete proteome] [HAMAP]
Taxonomic identifier554290 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity. HAMAP-Rule MF_00303

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_00303

Subcellular location

Cytoplasm. Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity. HAMAP-Rule MF_00303

Domain

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity. HAMAP-Rule MF_00303

Sequence similarities

Belongs to the FKBP-type PPIase family. Tig subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCytoplasm
   Molecular functionChaperone
Isomerase
Rotamase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

protein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Trigger factor HAMAP-Rule MF_00303
PRO_1000115579

Regions

Domain161 – 24686PPIase FKBP-type

Sequences

Sequence LengthMass (Da)Tools
B5BD84 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: B8D973998EE7D21C

FASTA43248,050
        10         20         30         40         50         60 
MQVSVETTQG LGRRVTITIA ADSIETAVKS ELVNVAKKVR IDGFRKGKVP MNIVAQRYGA 

        70         80         90        100        110        120 
SVRQDVLGDL MSRNFVDAII KEKINPAGAP NYVPGEYKVG EDFTYSVEFE VYPEVELTGL 

       130        140        150        160        170        180 
ESIEVEKPVV EVTDADVDVM LDTLRKQQAT WKEKDGAADA EDRVTIDFTG SVDGEEFEGG 

       190        200        210        220        230        240 
KATDFVLAMG QGRMIPGFED GVKGHKAGEE FTIDVTFPEE YHAENLKGKA AKFVINLKKV 

       250        260        270        280        290        300 
EERELPELTE EFIKRFGVED GSVAGLRAEV RKNMERELKG AVRNRVKSQA IEGLVKANDI 

       310        320        330        340        350        360 
DVPAALIDSE IDVLRRQAAQ RFGGNEKQAL ELPRELFEEQ AKRRVVVGLL LGEVIRTNEL 

       370        380        390        400        410        420 
KADEERVKGL IEEMASAYED PKEVIEFYSK NKELMDNMRN VALEEQAVEA VLAKAKVSEK 

       430 
ATSFNELMNQ QA 

« Hide

References

[1]"Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AKU_12601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM200053 Genomic DNA. Translation: CAR60327.1.
RefSeqYP_002142954.1. NC_011147.1.

3D structure databases

ProteinModelPortalB5BD84.
SMRB5BD84. Positions 1-432.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING554290.SSPA2117.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR60327; CAR60327; SSPA2117.
PATRIC32344413. VBISalEnt134303_2423.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0544.
HOGENOMHOG000218239.
OMAMQVSVEN.
OrthoDBEOG63VBX3.

Enzyme and pathway databases

BioCycSENT554290:GJDA-2267-MONOMER.

Family and domain databases

Gene3D1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPMF_00303. Trigger_factor_Tig.
InterProIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFPIRSF003095. Trigger_factor. 1 hit.
SUPFAMSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsTIGR00115. tig. 1 hit.
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTIG_SALPK
AccessionPrimary (citable) accession number: B5BD84
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families