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B5BD02

- B5BD02_SALPK

UniProt

B5BD02 - B5BD02_SALPK

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

SSPA2036

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).UniRule annotation

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: InterPro
  4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT554290:GJDA-2182-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthaseUniRule annotation (EC:6.3.4.18UniRule annotation)
Short name:
N5-CAIR synthaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetaseUniRule annotation
Gene namesi
Ordered Locus Names:SSPA2036Imported
OrganismiSalmonella paratyphi A (strain AKU_12601)Imported
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001869: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi554290.SSPA2036.

Structurei

3D structure databases

ProteinModelPortaliB5BD02.
SMRiB5BD02. Positions 1-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034026.
OMAiALQTWMP.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5BD02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQVCVLGNG QLGRMLRQAG EPLGIAVWPV GLDAAPTAVP VQQSVITAEI
60 70 80 90 100
ERWPETALTR ELARHPAFVN RDVFPIIADR LTQKQLFDKL GLATAPWQLL
110 120 130 140 150
TSADEWSGIF DRLGELAIIK RRVGGYDGRG QWRLRADETG QLPDDCYGEC
160 170 180 190 200
IVERGIHFSG EVSLVGARAH DGSTVFYPLT HNLHQDGILR TSVAFPQANA
210 220 230 240 250
EQQEQAESML SAIMQALNYV GVMAMECFIT PEGLLINELA PRVHNSGHWT
260 270 280 290 300
QNGASISQFE LHLRAITGLP LPAPVINTPS VMINLIGSEL NYDWLKLPLV
310 320 330 340 350
HLHWYDKAVR PGRKVGHLNL TDSDTSRLSA TLEALSPLLP GEYASGIIWA

QSKLK
Length:355
Mass (Da):39,084
Last modified:September 23, 2008 - v1
Checksum:i31BC196B36C50CB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR60243.1.
RefSeqiYP_002142873.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR60243; CAR60243; SSPA2036.
PATRICi32344235. VBISalEnt134303_2334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR60243.1 .
RefSeqi YP_002142873.1. NC_011147.1.

3D structure databases

ProteinModelPortali B5BD02.
SMRi B5BD02. Positions 1-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 554290.SSPA2036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR60243 ; CAR60243 ; SSPA2036 .
PATRICi 32344235. VBISalEnt134303_2334.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034026.
OMAi ALQTWMP.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci SENT554290:GJDA-2182-MONOMER.

Family and domain databases

Gene3Di 3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
    Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
    BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AKU_12601Imported.

Entry informationi

Entry nameiB5BD02_SALPK
AccessioniPrimary (citable) accession number: B5BD02
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3