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B5BB05

- PUR5_SALPK

UniProt

B5BB05 - PUR5_SALPK

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, SSPA0344
Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT554290:GJDA-364-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SSPA0344
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001869: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000193041Add
BLAST

Proteomic databases

PRIDEiB5BB05.

Interactioni

Protein-protein interaction databases

STRINGi554290.SSPA0344.

Structurei

3D structure databases

ProteinModelPortaliB5BB05.
SMRiB5BB05. Positions 5-345.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B5BB05-1 [UniParc]FASTAAdd to Basket

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MTDKTSLSYK DAGVDIDAGN ALVDRIKGVV KKTRRPEVMG GLGGFGALCA    50
LPQKYREPVL VSGTDGVGTK LRLAMDLKRH DAIGIDLVAM CVNDLVVQGA 100
EPLFFLDYYA TGKLDVDTAA SVINGIAEGC LQSGCALVGG ETAEMPGMYH 150
GEDYDVAGFC VGVVEKSEII DGSRVAEGDV LIALGSSGPH SNGYSLVRKI 200
IDVSGCDPQT TLLEGKPLAD HLLEPTRIYV KSVLELIENV DVHAIAHLTG 250
GGFWENIPRV LPENTQAVIN ESSWQWPAIF TWLQTAGNVS RHEMYRTFNC 300
GVGMVIALSA PEADKALALL NEKGENAWKI GIIKASDSEQ RVVIE 345
Length:345
Mass (Da):36,900
Last modified:September 23, 2008 - v1
Checksum:iDF7141C812A9D908
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM200053 Genomic DNA. Translation: CAR58466.1.
RefSeqiYP_002141189.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR58466; CAR58466; SSPA0344.
PATRICi32340266. VBISalEnt134303_0395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM200053 Genomic DNA. Translation: CAR58466.1 .
RefSeqi YP_002141189.1. NC_011147.1.

3D structure databases

ProteinModelPortali B5BB05.
SMRi B5BB05. Positions 5-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 554290.SSPA0344.

Proteomic databases

PRIDEi B5BB05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR58466 ; CAR58466 ; SSPA0344 .
PATRICi 32340266. VBISalEnt134303_0395.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SENT554290:GJDA-364-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
    Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
    BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AKU_12601.

Entry informationi

Entry nameiPUR5_SALPK
AccessioniPrimary (citable) accession number: B5BB05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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