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B5BAE8

- PEPT_SALPK

UniProt

B5BAE8 - PEPT_SALPK

Protein

Peptidase T

Gene

pepT

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Zinc 1UniRule annotation
    Active sitei80 – 801UniRule annotation
    Metal bindingi140 – 1401Zinc 1UniRule annotation
    Metal bindingi140 – 1401Zinc 2UniRule annotation
    Active sitei173 – 1731Proton acceptorUniRule annotation
    Metal bindingi174 – 1741Zinc 2UniRule annotation
    Metal bindingi196 – 1961Zinc 1UniRule annotation
    Metal bindingi379 – 3791Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSENT554290:GJDA-1613-MONOMER.

    Protein family/group databases

    MEROPSiM20.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:SSPA1508
    OrganismiSalmonella paratyphi A (strain AKU_12601)
    Taxonomic identifieri554290 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001869: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Peptidase TPRO_1000129044Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi554290.SSPA1508.

    Structurei

    3D structure databases

    ProteinModelPortaliB5BAE8.
    SMRiB5BAE8. Positions 1-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    HOGENOMiHOG000032390.
    OMAiDCYIEVT.
    OrthoDBiEOG6SV59Q.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5BAE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKLLERFLH YVSLDTQSKS GVRQVPSTEG QWKLLRLLKQ QLEEMGLVNI    50
    TLSEKGTLMA TLPANVEGDI PAIGFISHVD TSPDFSGKNV NPQIVENYRG 100
    GDIALGIGDE VLSPVMFPVL HQLLGQTLIT TDGKTLLGAD DKAGVAEIMT 150
    ALAVLKGNPI PHGEIKVAFT PDEEVGKGAK HFDVEEFGAQ WAYTVDGGGV 200
    GELEFENFNA ASVNIKIVGN NVHPGTAKGV MVNALSLAAR IHAEVPADEA 250
    PETTEGYEGF YHLASMKGTV DRAEMHYIIR DFDRKQFEAR KRKMMEIAKK 300
    VGKGLHPDCY IELVIEDSYY NMREKVVEHP HILDIAQQAM RDCHITPEMK 350
    PIRGGTDGAQ LSFMGLPCPN LFTGGYNYHG KHEFVTLEGM EKAVQVIVRI 400
    AELTAKRGQ 409
    Length:409
    Mass (Da):44,921
    Last modified:September 23, 2008 - v1
    Checksum:iE2C66902B8C698DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR59691.1.
    RefSeqiYP_002142347.1. NC_011147.1.

    Genome annotation databases

    EnsemblBacteriaiCAR59691; CAR59691; SSPA1508.
    PATRICi32342998. VBISalEnt134303_1733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM200053 Genomic DNA. Translation: CAR59691.1 .
    RefSeqi YP_002142347.1. NC_011147.1.

    3D structure databases

    ProteinModelPortali B5BAE8.
    SMRi B5BAE8. Positions 1-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 554290.SSPA1508.

    Protein family/group databases

    MEROPSi M20.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR59691 ; CAR59691 ; SSPA1508 .
    PATRICi 32342998. VBISalEnt134303_1733.

    Phylogenomic databases

    eggNOGi COG2195.
    HOGENOMi HOG000032390.
    OMAi DCYIEVT.
    OrthoDBi EOG6SV59Q.

    Enzyme and pathway databases

    BioCyci SENT554290:GJDA-1613-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
      Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
      BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AKU_12601.

    Entry informationi

    Entry nameiPEPT_SALPK
    AccessioniPrimary (citable) accession number: B5BAE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3