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B5BAE8

- PEPT_SALPK

UniProt

B5BAE8 - PEPT_SALPK

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Protein
Peptidase T
Gene
pepT, SSPA1508
Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides By similarity.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Zinc 1 By similarity
Active sitei80 – 801 By similarity
Metal bindingi140 – 1401Zinc 1 By similarity
Metal bindingi140 – 1401Zinc 2 By similarity
Active sitei173 – 1731Proton acceptor By similarity
Metal bindingi174 – 1741Zinc 2 By similarity
Metal bindingi196 – 1961Zinc 1 By similarity
Metal bindingi379 – 3791Zinc 2 By similarity

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW
  2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. peptide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT554290:GJDA-1613-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase T (EC:3.4.11.4)
Alternative name(s):
Aminotripeptidase
Short name:
Tripeptidase
Tripeptide aminopeptidase
Gene namesi
Name:pepT
Ordered Locus Names:SSPA1508
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001869: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Peptidase TUniRule annotation
PRO_1000129044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi554290.SSPA1508.

Structurei

3D structure databases

ProteinModelPortaliB5BAE8.
SMRiB5BAE8. Positions 1-408.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
OMAiDCYIEVT.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5BAE8-1 [UniParc]FASTAAdd to Basket

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MDKLLERFLH YVSLDTQSKS GVRQVPSTEG QWKLLRLLKQ QLEEMGLVNI    50
TLSEKGTLMA TLPANVEGDI PAIGFISHVD TSPDFSGKNV NPQIVENYRG 100
GDIALGIGDE VLSPVMFPVL HQLLGQTLIT TDGKTLLGAD DKAGVAEIMT 150
ALAVLKGNPI PHGEIKVAFT PDEEVGKGAK HFDVEEFGAQ WAYTVDGGGV 200
GELEFENFNA ASVNIKIVGN NVHPGTAKGV MVNALSLAAR IHAEVPADEA 250
PETTEGYEGF YHLASMKGTV DRAEMHYIIR DFDRKQFEAR KRKMMEIAKK 300
VGKGLHPDCY IELVIEDSYY NMREKVVEHP HILDIAQQAM RDCHITPEMK 350
PIRGGTDGAQ LSFMGLPCPN LFTGGYNYHG KHEFVTLEGM EKAVQVIVRI 400
AELTAKRGQ 409
Length:409
Mass (Da):44,921
Last modified:September 23, 2008 - v1
Checksum:iE2C66902B8C698DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM200053 Genomic DNA. Translation: CAR59691.1.
RefSeqiYP_002142347.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR59691; CAR59691; SSPA1508.
PATRICi32342998. VBISalEnt134303_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM200053 Genomic DNA. Translation: CAR59691.1 .
RefSeqi YP_002142347.1. NC_011147.1.

3D structure databases

ProteinModelPortali B5BAE8.
SMRi B5BAE8. Positions 1-408.
ModBasei Search...

Protein-protein interaction databases

STRINGi 554290.SSPA1508.

Protein family/group databases

MEROPSi M20.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR59691 ; CAR59691 ; SSPA1508 .
PATRICi 32342998. VBISalEnt134303_1733.

Phylogenomic databases

eggNOGi COG2195.
HOGENOMi HOG000032390.
OMAi DCYIEVT.
OrthoDBi EOG6SV59Q.

Enzyme and pathway databases

BioCyci SENT554290:GJDA-1613-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_00550. Aminopeptidase_M20.
InterProi IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
    Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
    BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AKU_12601.

Entry informationi

Entry nameiPEPT_SALPK
AccessioniPrimary (citable) accession number: B5BAE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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