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B5BAE8

- PEPT_SALPK

UniProt

B5BAE8 - PEPT_SALPK

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Protein

Peptidase T

Gene

pepT

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn(2+) ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Zinc 1UniRule annotation
Active sitei80 – 801UniRule annotation
Metal bindingi140 – 1401Zinc 1UniRule annotation
Metal bindingi140 – 1401Zinc 2UniRule annotation
Active sitei173 – 1731Proton acceptorUniRule annotation
Metal bindingi174 – 1741Zinc 2UniRule annotation
Metal bindingi196 – 1961Zinc 1UniRule annotation
Metal bindingi379 – 3791Zinc 2UniRule annotation

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW
  2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT554290:GJDA-1613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Ordered Locus Names:SSPA1508
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001869: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Peptidase TPRO_1000129044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi554290.SSPA1508.

Structurei

3D structure databases

ProteinModelPortaliB5BAE8.
SMRiB5BAE8. Positions 1-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
OMAiDCYIEVT.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5BAE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKLLERFLH YVSLDTQSKS GVRQVPSTEG QWKLLRLLKQ QLEEMGLVNI
60 70 80 90 100
TLSEKGTLMA TLPANVEGDI PAIGFISHVD TSPDFSGKNV NPQIVENYRG
110 120 130 140 150
GDIALGIGDE VLSPVMFPVL HQLLGQTLIT TDGKTLLGAD DKAGVAEIMT
160 170 180 190 200
ALAVLKGNPI PHGEIKVAFT PDEEVGKGAK HFDVEEFGAQ WAYTVDGGGV
210 220 230 240 250
GELEFENFNA ASVNIKIVGN NVHPGTAKGV MVNALSLAAR IHAEVPADEA
260 270 280 290 300
PETTEGYEGF YHLASMKGTV DRAEMHYIIR DFDRKQFEAR KRKMMEIAKK
310 320 330 340 350
VGKGLHPDCY IELVIEDSYY NMREKVVEHP HILDIAQQAM RDCHITPEMK
360 370 380 390 400
PIRGGTDGAQ LSFMGLPCPN LFTGGYNYHG KHEFVTLEGM EKAVQVIVRI

AELTAKRGQ
Length:409
Mass (Da):44,921
Last modified:September 23, 2008 - v1
Checksum:iE2C66902B8C698DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR59691.1.
RefSeqiYP_002142347.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR59691; CAR59691; SSPA1508.
PATRICi32342998. VBISalEnt134303_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR59691.1 .
RefSeqi YP_002142347.1. NC_011147.1.

3D structure databases

ProteinModelPortali B5BAE8.
SMRi B5BAE8. Positions 1-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 554290.SSPA1508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR59691 ; CAR59691 ; SSPA1508 .
PATRICi 32342998. VBISalEnt134303_1733.

Phylogenomic databases

eggNOGi COG2195.
HOGENOMi HOG000032390.
OMAi DCYIEVT.
OrthoDBi EOG6SV59Q.

Enzyme and pathway databases

BioCyci SENT554290:GJDA-1613-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_00550. Aminopeptidase_M20.
InterProi IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi."
    Holt K.E., Thomson N.R., Wain J., Langridge G.C., Hasan R., Bhutta Z.A., Quail M.A., Norbertczak H., Walker D., Simmonds M., White B., Bason N., Mungall K., Dougan G., Parkhill J.
    BMC Genomics 10:36-36(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AKU_12601.

Entry informationi

Entry nameiPEPT_SALPK
AccessioniPrimary (citable) accession number: B5BAE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3