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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Salmonella paratyphi A (strain AKU_12601)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-arginine degradation via AST pathway

This protein is involved in step 5 of the subpathway that synthesizes L-glutamate and succinate from L-arginine.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Arginine N-succinyltransferase (astA)
  2. N-succinylarginine dihydrolase (astB)
  3. Succinylornithine transaminase (astC)
  4. N-succinylglutamate 5-semialdehyde dehydrogenase (astD)
  5. Succinylglutamate desuccinylase (astE)
This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531ZincUniRule annotation
Metal bindingi56 – 561ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Active sitei210 – 2101UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT554290:GJDA-1526-MONOMER.
UniPathwayiUPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
Gene namesi
Name:astEUniRule annotation
Ordered Locus Names:SSPA1428
OrganismiSalmonella paratyphi A (strain AKU_12601)
Taxonomic identifieri554290 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Succinylglutamate desuccinylasePRO_1000133644Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB5BA68.
SMRiB5BA68. Positions 1-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280300.
KOiK05526.
OMAiAHAFTVE.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE. 1 hit.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

Sequencei

Sequence statusi: Complete.

B5BA68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNFLALTLS GTTPRVTQGK GAGFRWRWLS HGLLELTPDA PVDRALILSA
60 70 80 90 100
GIHGNETAPV EMLDKLLSAL YSGSLTLTWR VLVVLGNPQA LAAGIRYCHS
110 120 130 140 150
DMNRMFGGRW QSFAESDETR RARELELSLE TFFSSGQARV RWHLDLHTAI
160 170 180 190 200
RGSHHLRFGV LPQRDRPWET GFLAWLGAAG LEALVFHQAP GGTFTHFSSE
210 220 230 240 250
HFGALSCTLE LGKALPFGQN DLTQFSVTSQ ALSALLSGVE TSTSSSPPLR
260 270 280 290 300
YRVVSQITRH SDKFALYMDA QTLNFTAFAK GTLLAEEGDK RVTVTHDVEY
310 320
VLFPNPSVAC GLRAGLMLER LP
Length:322
Mass (Da):35,426
Last modified:September 23, 2008 - v1
Checksum:iE069E4A15EB48AEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR59607.1.
RefSeqiWP_000368463.1. NC_011147.1.

Genome annotation databases

EnsemblBacteriaiCAR59607; CAR59607; SSPA1428.
KEGGisek:SSPA1428.
PATRICi32342810. VBISalEnt134303_1641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM200053 Genomic DNA. Translation: CAR59607.1.
RefSeqiWP_000368463.1. NC_011147.1.

3D structure databases

ProteinModelPortaliB5BA68.
SMRiB5BA68. Positions 1-321.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR59607; CAR59607; SSPA1428.
KEGGisek:SSPA1428.
PATRICi32342810. VBISalEnt134303_1641.

Phylogenomic databases

HOGENOMiHOG000280300.
KOiK05526.
OMAiAHAFTVE.

Enzyme and pathway databases

UniPathwayiUPA00185; UER00283.
BioCyciSENT554290:GJDA-1526-MONOMER.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE. 1 hit.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiASTE_SALPK
AccessioniPrimary (citable) accession number: B5BA68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.