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B5B2P4

- B5B2P4_HUMAN

UniProt

B5B2P4 - B5B2P4_HUMAN

Protein
Submitted name:

Nuclear factor of activated T-cells c2 isoform IA-IIS-deltaXa

Gene

NFATC2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. cytokine production Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nuclear factor of activated T-cells c2 isoform IA-IIS-deltaXaImported
    Submitted name:
    Nuclear factor of activated T-cells c2 isoform IB-IIS-deltaXaImported
    Gene namesi
    Name:NFATC2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: UniProtKB-KW
    3. ribonucleoprotein complex Source: Ensembl
    4. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Expressioni

    Gene expression databases

    ArrayExpressiB5B2P4.
    BgeeiB5B2P4.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RHD (Rel-like) domain.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG069754.
    KOiK17332.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PANTHERiPTHR12533. PTHR12533. 1 hit.
    PfamiPF00554. RHD. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view]
    PRINTSiPR01789. NUCFACTORATC.
    SMARTiSM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS50254. REL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5B2P4-1 [UniParc]FASTAAdd to Basket

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    MSPRTSLAED SCLGRHSPVP RPASRSSSPG AKRRHSCAEA LVALPPGASP    50
    QRSRSPSPQP SSHVAPQDHG SPAGYPPVAG SAVIMDALNS LATDSPCGIP 100
    PKMWKTSPDP SPVSAAPSKA GLPRHIYPAV EFLGPCEQGE RRNSAPESIL 150
    LVPPTWPKPL VPAIPICSIP VTASLPPLEW PLSSQSGSYE LRIEVQPKPH 200
    HRAHYETEGS RGAVKAPTGG HPVVQLHGYM ENKPLGLQIF IGTADERILK 250
    PHAFYQVHRI TGKTVTTTSY EKIVGNTKVL EIPLEPKNNM RATIDCAGIL 300
    KLRNADIELR KGETDIGRKN TRVRLVFRVH IPESSGRIVS LQTASNPIEC 350
    SQRSAHELPM VERQDTDSCL VYGGQQMILT GQNFTSESKV VFTEKTTDGQ 400
    QIWEMEATVD KDKSQPNMLF VEIPEYRNKH IRTPVKVNFY VINGKRKRSQ 450
    PQHFTYHPVP AIKTEPTDEY DPTLICSPTH GGLGSQPYYP QHPMVAESPS 500
    CLVATMAPCQ QFRTGLSSPD ARYQQQNPAA VLYQRSKSLS PSLLGYQQPA 550
    LMAAPLSLAD AHRSVLVHAG SQGQSSALLH PSPTNQQASP VIHYSPTNQQ 600
    LRCGSHQEFQ HIMYCENFAP GTTRPGPPPV SQGQRLSPGS YPTVIQQQNA 650
    TSQRAAKNGP PVSDQKEVLP AGVTIKQEQN LDQTYLDDVN EIIRKEFSGP 700
    PARNQT 706
    Length:706
    Mass (Da):77,061
    Last modified:September 23, 2008 - v1
    Checksum:i69EA7AAB0EC54634
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU887579 mRNA. Translation: ACG55599.1.
    EU887580 mRNA. Translation: ACG55600.1.
    RefSeqiNP_001245224.1. NM_001258295.1.
    NP_001245226.1. NM_001258297.1.
    UniGeneiHs.744148.

    Genome annotation databases

    GeneIDi4773.
    KEGGihsa:4773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU887579 mRNA. Translation: ACG55599.1 .
    EU887580 mRNA. Translation: ACG55600.1 .
    RefSeqi NP_001245224.1. NM_001258295.1.
    NP_001245226.1. NM_001258297.1.
    UniGenei Hs.744148.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4773.
    KEGGi hsa:4773.

    Organism-specific databases

    CTDi 4773.

    Phylogenomic databases

    HOVERGENi HBG069754.
    KOi K17332.

    Miscellaneous databases

    GenomeRNAii 4773.
    NextBioi 18400.

    Gene expression databases

    ArrayExpressi B5B2P4.
    Bgeei B5B2P4.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    PANTHERi PTHR12533. PTHR12533. 1 hit.
    Pfami PF00554. RHD. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view ]
    PRINTSi PR01789. NUCFACTORATC.
    SMARTi SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative splicing and expression of human and mouse NFAT genes."
      Vihma H., Pruunsild P., Timmusk T.
      Genomics 0:0-0(2008)
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiB5B2P4_HUMAN
    AccessioniPrimary (citable) accession number: B5B2P4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.