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B5B2P4

- B5B2P4_HUMAN

UniProt

B5B2P4 - B5B2P4_HUMAN

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Protein
Submitted name:

Nuclear factor of activated T-cells c2 isoform IA-IIS-deltaXa

Gene

NFATC2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. cytokine production Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of activated T-cells c2 isoform IA-IIS-deltaXaImported
Submitted name:
Nuclear factor of activated T-cells c2 isoform IB-IIS-deltaXaImported
Gene namesi
Name:NFATC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nuclear transcription factor complex Source: Ensembl
  3. ribonucleoprotein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiB5B2P4.
ExpressionAtlasiB5B2P4. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG069754.
KOiK17332.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PfamiPF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5B2P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPRTSLAED SCLGRHSPVP RPASRSSSPG AKRRHSCAEA LVALPPGASP
60 70 80 90 100
QRSRSPSPQP SSHVAPQDHG SPAGYPPVAG SAVIMDALNS LATDSPCGIP
110 120 130 140 150
PKMWKTSPDP SPVSAAPSKA GLPRHIYPAV EFLGPCEQGE RRNSAPESIL
160 170 180 190 200
LVPPTWPKPL VPAIPICSIP VTASLPPLEW PLSSQSGSYE LRIEVQPKPH
210 220 230 240 250
HRAHYETEGS RGAVKAPTGG HPVVQLHGYM ENKPLGLQIF IGTADERILK
260 270 280 290 300
PHAFYQVHRI TGKTVTTTSY EKIVGNTKVL EIPLEPKNNM RATIDCAGIL
310 320 330 340 350
KLRNADIELR KGETDIGRKN TRVRLVFRVH IPESSGRIVS LQTASNPIEC
360 370 380 390 400
SQRSAHELPM VERQDTDSCL VYGGQQMILT GQNFTSESKV VFTEKTTDGQ
410 420 430 440 450
QIWEMEATVD KDKSQPNMLF VEIPEYRNKH IRTPVKVNFY VINGKRKRSQ
460 470 480 490 500
PQHFTYHPVP AIKTEPTDEY DPTLICSPTH GGLGSQPYYP QHPMVAESPS
510 520 530 540 550
CLVATMAPCQ QFRTGLSSPD ARYQQQNPAA VLYQRSKSLS PSLLGYQQPA
560 570 580 590 600
LMAAPLSLAD AHRSVLVHAG SQGQSSALLH PSPTNQQASP VIHYSPTNQQ
610 620 630 640 650
LRCGSHQEFQ HIMYCENFAP GTTRPGPPPV SQGQRLSPGS YPTVIQQQNA
660 670 680 690 700
TSQRAAKNGP PVSDQKEVLP AGVTIKQEQN LDQTYLDDVN EIIRKEFSGP

PARNQT
Length:706
Mass (Da):77,061
Last modified:September 23, 2008 - v1
Checksum:i69EA7AAB0EC54634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU887579 mRNA. Translation: ACG55599.1.
EU887580 mRNA. Translation: ACG55600.1.
RefSeqiNP_001245224.1. NM_001258295.1.
NP_001245226.1. NM_001258297.1.
UniGeneiHs.744148.

Genome annotation databases

GeneIDi4773.
KEGGihsa:4773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU887579 mRNA. Translation: ACG55599.1 .
EU887580 mRNA. Translation: ACG55600.1 .
RefSeqi NP_001245224.1. NM_001258295.1.
NP_001245226.1. NM_001258297.1.
UniGenei Hs.744148.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4773.
KEGGi hsa:4773.

Organism-specific databases

CTDi 4773.

Phylogenomic databases

HOVERGENi HBG069754.
KOi K17332.

Miscellaneous databases

ChiTaRSi NFATC2. human.
GenomeRNAii 4773.
NextBioi 18400.

Gene expression databases

Bgeei B5B2P4.
ExpressionAtlasi B5B2P4. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view ]
PANTHERi PTHR12533. PTHR12533. 1 hit.
Pfami PF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view ]
PRINTSi PR01789. NUCFACTORATC.
SMARTi SM00429. IPT. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS50254. REL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Alternative splicing and expression of human and mouse NFAT genes."
    Vihma H., Pruunsild P., Timmusk T.
    Genomics 0:0-0(2008)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB5B2P4_HUMAN
AccessioniPrimary (citable) accession number: B5B2P4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.