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B5B2P0

- B5B2P0_HUMAN

UniProt

B5B2P0 - B5B2P0_HUMAN

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Protein
Submitted name: Nuclear factor of activated T-cells c2 isoform IA-IIS-Xa
Gene
NFATC2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of activated T-cells c2 isoform IA-IIS-XaImported
Submitted name:
Nuclear factor of activated T-cells c2 isoform IB-IIS-XaImported
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 2Imported
Gene namesi
Name:NFATC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:7776. NFATC2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG069754.
KOiK17332.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PfamiPF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5B2P0-1 [UniParc]FASTAAdd to Basket

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MSPRTSLAED SCLGRHSPVP RPASRSSSPG AKRRHSCAEA LVALPPGASP    50
QRSRSPSPQP SSHVAPQDHG SPAGYPPVAG SAVIMDALNS LATDSPCGIP 100
PKMWKTSPDP SPVSAAPSKA GLPRHIYPAV EFLGPCEQGE RRNSAPESIL 150
LVPPTWPKPL VPAIPICSIP VTASLPPLEW PLSSQSGSYE LRIEVQPKPH 200
HRAHYETEGS RGAVKAPTGG HPVVQLHGYM ENKPLGLQIF IGTADERILK 250
PHAFYQVHRI TGKTVTTTSY EKIVGNTKVL EIPLEPKNNM RATIDCAGIL 300
KLRNADIELR KGETDIGRKN TRVRLVFRVH IPESSGRIVS LQTASNPIEC 350
SQRSAHELPM VERQDTDSCL VYGGQQMILT GQNFTSESKV VFTEKTTDGQ 400
QIWEMEATVD KDKSQPNMLF VEIPEYRNKH IRTPVKVNFY VINGKRKRSQ 450
PQHFTYHPVP AIKTEPTDEY DPTLICSPTH GGLGSQPYYP QHPMVAESPS 500
CLVATMAPCQ QFRTGLSSPD ARYQQQNPAA VLYQRSKSLS PSLLGYQQPA 550
LMAAPLSLAD AHRSVLVHAG SQGQSSALLH PSPTNQQASP VIHYSPTNQQ 600
LRCGSHQEFQ HIMYCENFAP GTTRPGPPPV SQGQRLSPGS YPTVIQQQNA 650
TSQRAAKNGP PVSDQKEVLP AGVTIKQEQN LDQTYLDDEL IDTHLSWIQN 700
IL 702
Length:702
Mass (Da):76,700
Last modified:September 23, 2008 - v1
Checksum:iD3CA427C994A5605
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035682 Genomic DNA. No translation available.
AL035684 Genomic DNA. No translation available.
AL132866 Genomic DNA. No translation available.
EU887575 mRNA. Translation: ACG55595.1.
EU887576 mRNA. Translation: ACG55596.1.
RefSeqiNP_001245223.1. NM_001258294.1.
NP_001245225.1. NM_001258296.1.
NP_036472.2. NM_012340.4.
NP_775114.1. NM_173091.3.
UniGeneiHs.744148.

Genome annotation databases

EnsembliENST00000609507; ENSP00000477342; ENSG00000101096.
ENST00000610033; ENSP00000477142; ENSG00000101096.
GeneIDi4773.
KEGGihsa:4773.
UCSCiuc010zyv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035682 Genomic DNA. No translation available.
AL035684 Genomic DNA. No translation available.
AL132866 Genomic DNA. No translation available.
EU887575 mRNA. Translation: ACG55595.1 .
EU887576 mRNA. Translation: ACG55596.1 .
RefSeqi NP_001245223.1. NM_001258294.1.
NP_001245225.1. NM_001258296.1.
NP_036472.2. NM_012340.4.
NP_775114.1. NM_173091.3.
UniGenei Hs.744148.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000609507 ; ENSP00000477342 ; ENSG00000101096 .
ENST00000610033 ; ENSP00000477142 ; ENSG00000101096 .
GeneIDi 4773.
KEGGi hsa:4773.
UCSCi uc010zyv.3. human.

Organism-specific databases

CTDi 4773.
HGNCi HGNC:7776. NFATC2.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG069754.
KOi K17332.

Miscellaneous databases

GenomeRNAii 4773.
NextBioi 18400.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view ]
PANTHERi PTHR12533. PTHR12533. 1 hit.
Pfami PF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view ]
PRINTSi PR01789. NUCFACTORATC.
SMARTi SM00429. IPT. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS50254. REL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Alternative splicing and expression of human and mouse NFAT genes."
    Vihma H., Pruunsild P., Timmusk T.
    Genomics 0:0-0(2008)
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (DEC-2013) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB5B2P0_HUMAN
AccessioniPrimary (citable) accession number: B5B2P0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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