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B5B2N2 (B5B2N2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Nuclear factor of-activated T-cells, cytoplasmic 1 Ensembl ENSMUSP00000129001
Gene names
Name:Nfatc1 Ensembl ENSMUSP00000129001 MGI 102469
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length939 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RHD (Rel-like) domain. RuleBase RU003997

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU003998
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG1/S transition of mitotic cell cycle

Inferred from mutant phenotype PubMed 12660151. Source: MGI

calcium ion transport

Inferred from mutant phenotype PubMed 12660151. Source: MGI

epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 15339668. Source: MGI

heart development

Inferred from mutant phenotype PubMed 15339668. Source: MGI

intracellular signal transduction

Inferred from sequence orthology PubMed 14749367. Source: MGI

osteoclast differentiation

Inferred from genetic interaction PubMed 21982707. Source: MGI

positive regulation of gene expression

Inferred from direct assay PubMed 22451653. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17430895. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from sequence orthology PubMed 14749367. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 10903175PubMed 12091710PubMed 12469121PubMed 21982707. Source: MGI

nuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 10903175PubMed 11782539PubMed 12970181PubMed 15850572PubMed 21464233PubMed 21982707. Source: MGI

transcription factor complex

Inferred from physical interaction PubMed 19561615. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 23980096. Source: MGI

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 23980096. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 15058383. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B5B2N2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: A7639723937E81F7

FASTA939101,610
        10         20         30         40         50         60 
MPSTSFPVPS KFPLGPPAAV CGSGETLRPA PPSGGTMKAA EEEHYSYVSP SVTSTLPLPT 

        70         80         90        100        110        120 
AHSALPAACH DLQTSTPGIS AVPSANHPPS YGGAVDSGPS GYFLSSGNTR PNGAPTLESP 

       130        140        150        160        170        180 
RIEITSYLGL HHGSGQFFHD VEVEDVLPSC KRSPSTATLH LPSLEAYRDP SCLSPASSLS 

       190        200        210        220        230        240 
SRSCNSEASS YESNYSYPYA SPQTSPWQSP CVSPKTTDPE EGFPRSLGAC HLLGSPRHSP 

       250        260        270        280        290        300 
STSPRASITE ESWLGARGSR PTSPCNKRKY SLNGRQPSCS PHHSPTPSPH GSPRVSVTED 

       310        320        330        340        350        360 
TWLGNTTQYT SSAIVAAINA LTTDSTLDLG DGVPIKSRKT ALEHAPSVAL KVEPAGEDLG 

       370        380        390        400        410        420 
TTPPTSDFPP EEYTFQHLRK GAFCEQYLSV PQASYQWAKP KSLSPTSYMS PSLPALDWQL 

       430        440        450        460        470        480 
PSHSGPYELR IEVQPKSHHR AHYETEGSRG AVKASAGGHP IVQLHGYLEN EPLTLQLFIG 

       490        500        510        520        530        540 
TADDRLLRPH AFYQVHRITG KTVSTTSHEI ILSNTKVLEI PLLPENNMRA IIDCAGILKL 

       550        560        570        580        590        600 
RNSDIELRKG ETDIGRKNTR VRLVFRVHIP QPNGRTLSLQ VASNPIECSQ RSAQELPLVE 

       610        620        630        640        650        660 
KQSTDSYPVI GGKKMVLSGH NFLQDSKVIF VEKAPDGHHV WEMEAKTDRD LCKPNSLVVE 

       670        680        690        700        710        720 
IPPFRNQRIT SPVQVSFYVC NGKRKRSQYQ RFTYLPANVP IIKTEPTDDF EPALTCGPMS 

       730        740        750        760        770        780 
QGISPLPRPY YSQQLTMPPD PGSCLVAGFA PCSQRNTLMP TPPNASPKLH DLSSPAYTKG 

       790        800        810        820        830        840 
LTNPGHSGHL GLQPPASEAP TMQEVPRPMA IQPNSPEQPP SARLQPQVSP HLNSSCPLGR 

       850        860        870        880        890        900 
RQVLCPNSPS SPLPSAAQEP ACLQSSALPP DMGHRQPQPQ KVQRNESPAV LPEVCEDSGH 

       910        920        930 
NLAPIPVVIK QEPEELDQLY LDDVNEIIRN DLSSTIPHS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC123818 Genomic DNA. No translation available.
AC149054 Genomic DNA. No translation available.
EU887567 mRNA. Translation: ACG55587.1.
RefSeqNP_001157582.1. NM_001164110.1.
UniGeneMm.329560.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000077196.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000170905; ENSMUSP00000129001; ENSMUSG00000033016.
GeneID18018.
KEGGmmu:18018.
UCSCuc012bfm.1. mouse.

Organism-specific databases

CTD4772.
MGIMGI:102469. Nfatc1.

Phylogenomic databases

GeneTreeENSGT00550000074562.
HOGENOMHOG000231780.
HOVERGENHBG069754.
InParanoidB5B2N2.
KOK04446.
OMAHNNNQFF.
OrthoDBEOG79PJND.
TreeFamTF326480.

Gene expression databases

GenevestigatorB5B2N2.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PANTHERPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamPF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PRINTSPR01789. NUCFACTORATC.
SMARTSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEPS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293057.
SOURCESearch...

Entry information

Entry nameB5B2N2_MOUSE
AccessionPrimary (citable) accession number: B5B2N2
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)