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Protein
Submitted name:

Nuclear factor of activated T-cells c1 isoform IA-IXL

Gene

Nfatc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. intracellular signal transduction Source: Ensembl
  2. positive regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_331940. Ca2+ pathway.
REACT_348733. FCERI mediated Ca+2 mobilization.

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of activated T-cells c1 isoform IA-IXLImported
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 1Imported
Gene namesi
Name:Nfatc1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:102469. Nfatc1.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriB5B2N2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077196.

Family & Domainsi

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074562.
HOGENOMiHOG000231780.
HOVERGENiHBG069754.
KOiK04446.
OMAiHNNNQFF.
OrthoDBiEOG79PJND.
TreeFamiTF326480.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamiPF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5B2N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTSFPVPS KFPLGPPAAV CGSGETLRPA PPSGGTMKAA EEEHYSYVSP
60 70 80 90 100
SVTSTLPLPT AHSALPAACH DLQTSTPGIS AVPSANHPPS YGGAVDSGPS
110 120 130 140 150
GYFLSSGNTR PNGAPTLESP RIEITSYLGL HHGSGQFFHD VEVEDVLPSC
160 170 180 190 200
KRSPSTATLH LPSLEAYRDP SCLSPASSLS SRSCNSEASS YESNYSYPYA
210 220 230 240 250
SPQTSPWQSP CVSPKTTDPE EGFPRSLGAC HLLGSPRHSP STSPRASITE
260 270 280 290 300
ESWLGARGSR PTSPCNKRKY SLNGRQPSCS PHHSPTPSPH GSPRVSVTED
310 320 330 340 350
TWLGNTTQYT SSAIVAAINA LTTDSTLDLG DGVPIKSRKT ALEHAPSVAL
360 370 380 390 400
KVEPAGEDLG TTPPTSDFPP EEYTFQHLRK GAFCEQYLSV PQASYQWAKP
410 420 430 440 450
KSLSPTSYMS PSLPALDWQL PSHSGPYELR IEVQPKSHHR AHYETEGSRG
460 470 480 490 500
AVKASAGGHP IVQLHGYLEN EPLTLQLFIG TADDRLLRPH AFYQVHRITG
510 520 530 540 550
KTVSTTSHEI ILSNTKVLEI PLLPENNMRA IIDCAGILKL RNSDIELRKG
560 570 580 590 600
ETDIGRKNTR VRLVFRVHIP QPNGRTLSLQ VASNPIECSQ RSAQELPLVE
610 620 630 640 650
KQSTDSYPVI GGKKMVLSGH NFLQDSKVIF VEKAPDGHHV WEMEAKTDRD
660 670 680 690 700
LCKPNSLVVE IPPFRNQRIT SPVQVSFYVC NGKRKRSQYQ RFTYLPANVP
710 720 730 740 750
IIKTEPTDDF EPALTCGPMS QGISPLPRPY YSQQLTMPPD PGSCLVAGFA
760 770 780 790 800
PCSQRNTLMP TPPNASPKLH DLSSPAYTKG LTNPGHSGHL GLQPPASEAP
810 820 830 840 850
TMQEVPRPMA IQPNSPEQPP SARLQPQVSP HLNSSCPLGR RQVLCPNSPS
860 870 880 890 900
SPLPSAAQEP ACLQSSALPP DMGHRQPQPQ KVQRNESPAV LPEVCEDSGH
910 920 930
NLAPIPVVIK QEPEELDQLY LDDVNEIIRN DLSSTIPHS
Length:939
Mass (Da):101,610
Last modified:September 23, 2008 - v1
Checksum:iA7639723937E81F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123818 Genomic DNA. No translation available.
AC149054 Genomic DNA. No translation available.
EU887567 mRNA. Translation: ACG55587.1.
RefSeqiNP_001157582.1. NM_001164110.1.
UniGeneiMm.329560.

Genome annotation databases

EnsembliENSMUST00000170905; ENSMUSP00000129001; ENSMUSG00000033016.
GeneIDi18018.
KEGGimmu:18018.
UCSCiuc012bfm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123818 Genomic DNA. No translation available.
AC149054 Genomic DNA. No translation available.
EU887567 mRNA. Translation: ACG55587.1.
RefSeqiNP_001157582.1. NM_001164110.1.
UniGeneiMm.329560.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170905; ENSMUSP00000129001; ENSMUSG00000033016.
GeneIDi18018.
KEGGimmu:18018.
UCSCiuc012bfm.1. mouse.

Organism-specific databases

CTDi4772.
MGIiMGI:102469. Nfatc1.

Phylogenomic databases

GeneTreeiENSGT00550000074562.
HOGENOMiHOG000231780.
HOVERGENiHBG069754.
KOiK04446.
OMAiHNNNQFF.
OrthoDBiEOG79PJND.
TreeFamiTF326480.

Enzyme and pathway databases

ReactomeiREACT_331940. Ca2+ pathway.
REACT_348733. FCERI mediated Ca+2 mobilization.

Miscellaneous databases

NextBioi293057.
SOURCEiSearch...

Gene expression databases

GenevestigatoriB5B2N2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamiPF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing and expression of human and mouse NFAT genes."
    Vihma H., Pruunsild P., Timmusk T.
    Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB5B2N2_MOUSE
AccessioniPrimary (citable) accession number: B5B2N2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 29, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.