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B5B2N2

- B5B2N2_MOUSE

UniProt

B5B2N2 - B5B2N2_MOUSE

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Protein
Submitted name:

Nuclear factor of activated T-cells c1 isoform IA-IXL

Gene
Nfatc1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. calcium ion transport Source: MGI
  2. epithelial to mesenchymal transition Source: MGI
  3. G1/S transition of mitotic cell cycle Source: MGI
  4. heart development Source: MGI
  5. intracellular signal transduction Source: MGI
  6. osteoclast differentiation Source: MGI
  7. positive regulation of gene expression Source: MGI
  8. positive regulation of transcription, DNA-templated Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_188202. FCERI mediated Ca+2 mobilization.
REACT_221970. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of activated T-cells c1 isoform IA-IXLImported
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 1Imported
Gene namesi
Name:Nfatc1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:102469. Nfatc1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear chromatin Source: Ensembl
  3. nucleus Source: MGI
  4. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriB5B2N2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077196.

Family & Domainsi

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074562.
HOGENOMiHOG000231780.
HOVERGENiHBG069754.
InParanoidiB5B2N2.
KOiK04446.
OMAiHNNNQFF.
OrthoDBiEOG79PJND.
TreeFamiTF326480.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamiPF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5B2N2-1 [UniParc]FASTAAdd to Basket

« Hide

MPSTSFPVPS KFPLGPPAAV CGSGETLRPA PPSGGTMKAA EEEHYSYVSP    50
SVTSTLPLPT AHSALPAACH DLQTSTPGIS AVPSANHPPS YGGAVDSGPS 100
GYFLSSGNTR PNGAPTLESP RIEITSYLGL HHGSGQFFHD VEVEDVLPSC 150
KRSPSTATLH LPSLEAYRDP SCLSPASSLS SRSCNSEASS YESNYSYPYA 200
SPQTSPWQSP CVSPKTTDPE EGFPRSLGAC HLLGSPRHSP STSPRASITE 250
ESWLGARGSR PTSPCNKRKY SLNGRQPSCS PHHSPTPSPH GSPRVSVTED 300
TWLGNTTQYT SSAIVAAINA LTTDSTLDLG DGVPIKSRKT ALEHAPSVAL 350
KVEPAGEDLG TTPPTSDFPP EEYTFQHLRK GAFCEQYLSV PQASYQWAKP 400
KSLSPTSYMS PSLPALDWQL PSHSGPYELR IEVQPKSHHR AHYETEGSRG 450
AVKASAGGHP IVQLHGYLEN EPLTLQLFIG TADDRLLRPH AFYQVHRITG 500
KTVSTTSHEI ILSNTKVLEI PLLPENNMRA IIDCAGILKL RNSDIELRKG 550
ETDIGRKNTR VRLVFRVHIP QPNGRTLSLQ VASNPIECSQ RSAQELPLVE 600
KQSTDSYPVI GGKKMVLSGH NFLQDSKVIF VEKAPDGHHV WEMEAKTDRD 650
LCKPNSLVVE IPPFRNQRIT SPVQVSFYVC NGKRKRSQYQ RFTYLPANVP 700
IIKTEPTDDF EPALTCGPMS QGISPLPRPY YSQQLTMPPD PGSCLVAGFA 750
PCSQRNTLMP TPPNASPKLH DLSSPAYTKG LTNPGHSGHL GLQPPASEAP 800
TMQEVPRPMA IQPNSPEQPP SARLQPQVSP HLNSSCPLGR RQVLCPNSPS 850
SPLPSAAQEP ACLQSSALPP DMGHRQPQPQ KVQRNESPAV LPEVCEDSGH 900
NLAPIPVVIK QEPEELDQLY LDDVNEIIRN DLSSTIPHS 939
Length:939
Mass (Da):101,610
Last modified:September 23, 2008 - v1
Checksum:iA7639723937E81F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123818 Genomic DNA. No translation available.
AC149054 Genomic DNA. No translation available.
EU887567 mRNA. Translation: ACG55587.1.
RefSeqiNP_001157582.1. NM_001164110.1.
UniGeneiMm.329560.

Genome annotation databases

EnsembliENSMUST00000170905; ENSMUSP00000129001; ENSMUSG00000033016.
GeneIDi18018.
KEGGimmu:18018.
UCSCiuc012bfm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123818 Genomic DNA. No translation available.
AC149054 Genomic DNA. No translation available.
EU887567 mRNA. Translation: ACG55587.1 .
RefSeqi NP_001157582.1. NM_001164110.1.
UniGenei Mm.329560.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000170905 ; ENSMUSP00000129001 ; ENSMUSG00000033016 .
GeneIDi 18018.
KEGGi mmu:18018.
UCSCi uc012bfm.1. mouse.

Organism-specific databases

CTDi 4772.
MGIi MGI:102469. Nfatc1.

Phylogenomic databases

GeneTreei ENSGT00550000074562.
HOGENOMi HOG000231780.
HOVERGENi HBG069754.
InParanoidi B5B2N2.
KOi K04446.
OMAi HNNNQFF.
OrthoDBi EOG79PJND.
TreeFami TF326480.

Enzyme and pathway databases

Reactomei REACT_188202. FCERI mediated Ca+2 mobilization.
REACT_221970. Ca2+ pathway.

Miscellaneous databases

NextBioi 293057.
SOURCEi Search...

Gene expression databases

Genevestigatori B5B2N2.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view ]
PANTHERi PTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
Pfami PF00554. RHD. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view ]
PRINTSi PR01789. NUCFACTORATC.
SMARTi SM00429. IPT. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS50254. REL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative splicing and expression of human and mouse NFAT genes."
    Vihma H., Pruunsild P., Timmusk T.
    Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB5B2N2_MOUSE
AccessioniPrimary (citable) accession number: B5B2N2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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