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B5B2N2

- B5B2N2_MOUSE

UniProt

B5B2N2 - B5B2N2_MOUSE

Protein
Submitted name:

Nuclear factor of activated T-cells c1 isoform IA-IXL

Gene

Nfatc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: MGI
    2. epithelial to mesenchymal transition Source: MGI
    3. G1/S transition of mitotic cell cycle Source: MGI
    4. heart development Source: MGI
    5. intracellular signal transduction Source: MGI
    6. osteoclast differentiation Source: MGI
    7. positive regulation of gene expression Source: MGI
    8. positive regulation of transcription, DNA-templated Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_221970. Ca2+ pathway.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nuclear factor of activated T-cells c1 isoform IA-IXLImported
    Submitted name:
    Nuclear factor of-activated T-cells, cytoplasmic 1Imported
    Gene namesi
    Name:Nfatc1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:102469. Nfatc1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nuclear chromatin Source: Ensembl
    3. nucleus Source: MGI
    4. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriB5B2N2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000077196.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RHD (Rel-like) domain.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074562.
    HOGENOMiHOG000231780.
    HOVERGENiHBG069754.
    InParanoidiB5B2N2.
    KOiK04446.
    OMAiHNNNQFF.
    OrthoDBiEOG79PJND.
    TreeFamiTF326480.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR015647. NFAT1.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PANTHERiPTHR12533. PTHR12533. 1 hit.
    PTHR12533:SF5. PTHR12533:SF5. 1 hit.
    PfamiPF00554. RHD. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view]
    PRINTSiPR01789. NUCFACTORATC.
    SMARTiSM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS50254. REL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5B2N2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSTSFPVPS KFPLGPPAAV CGSGETLRPA PPSGGTMKAA EEEHYSYVSP    50
    SVTSTLPLPT AHSALPAACH DLQTSTPGIS AVPSANHPPS YGGAVDSGPS 100
    GYFLSSGNTR PNGAPTLESP RIEITSYLGL HHGSGQFFHD VEVEDVLPSC 150
    KRSPSTATLH LPSLEAYRDP SCLSPASSLS SRSCNSEASS YESNYSYPYA 200
    SPQTSPWQSP CVSPKTTDPE EGFPRSLGAC HLLGSPRHSP STSPRASITE 250
    ESWLGARGSR PTSPCNKRKY SLNGRQPSCS PHHSPTPSPH GSPRVSVTED 300
    TWLGNTTQYT SSAIVAAINA LTTDSTLDLG DGVPIKSRKT ALEHAPSVAL 350
    KVEPAGEDLG TTPPTSDFPP EEYTFQHLRK GAFCEQYLSV PQASYQWAKP 400
    KSLSPTSYMS PSLPALDWQL PSHSGPYELR IEVQPKSHHR AHYETEGSRG 450
    AVKASAGGHP IVQLHGYLEN EPLTLQLFIG TADDRLLRPH AFYQVHRITG 500
    KTVSTTSHEI ILSNTKVLEI PLLPENNMRA IIDCAGILKL RNSDIELRKG 550
    ETDIGRKNTR VRLVFRVHIP QPNGRTLSLQ VASNPIECSQ RSAQELPLVE 600
    KQSTDSYPVI GGKKMVLSGH NFLQDSKVIF VEKAPDGHHV WEMEAKTDRD 650
    LCKPNSLVVE IPPFRNQRIT SPVQVSFYVC NGKRKRSQYQ RFTYLPANVP 700
    IIKTEPTDDF EPALTCGPMS QGISPLPRPY YSQQLTMPPD PGSCLVAGFA 750
    PCSQRNTLMP TPPNASPKLH DLSSPAYTKG LTNPGHSGHL GLQPPASEAP 800
    TMQEVPRPMA IQPNSPEQPP SARLQPQVSP HLNSSCPLGR RQVLCPNSPS 850
    SPLPSAAQEP ACLQSSALPP DMGHRQPQPQ KVQRNESPAV LPEVCEDSGH 900
    NLAPIPVVIK QEPEELDQLY LDDVNEIIRN DLSSTIPHS 939
    Length:939
    Mass (Da):101,610
    Last modified:September 23, 2008 - v1
    Checksum:iA7639723937E81F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123818 Genomic DNA. No translation available.
    AC149054 Genomic DNA. No translation available.
    EU887567 mRNA. Translation: ACG55587.1.
    RefSeqiNP_001157582.1. NM_001164110.1.
    UniGeneiMm.329560.

    Genome annotation databases

    EnsembliENSMUST00000170905; ENSMUSP00000129001; ENSMUSG00000033016.
    GeneIDi18018.
    KEGGimmu:18018.
    UCSCiuc012bfm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123818 Genomic DNA. No translation available.
    AC149054 Genomic DNA. No translation available.
    EU887567 mRNA. Translation: ACG55587.1 .
    RefSeqi NP_001157582.1. NM_001164110.1.
    UniGenei Mm.329560.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000077196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000170905 ; ENSMUSP00000129001 ; ENSMUSG00000033016 .
    GeneIDi 18018.
    KEGGi mmu:18018.
    UCSCi uc012bfm.1. mouse.

    Organism-specific databases

    CTDi 4772.
    MGIi MGI:102469. Nfatc1.

    Phylogenomic databases

    GeneTreei ENSGT00550000074562.
    HOGENOMi HOG000231780.
    HOVERGENi HBG069754.
    InParanoidi B5B2N2.
    KOi K04446.
    OMAi HNNNQFF.
    OrthoDBi EOG79PJND.
    TreeFami TF326480.

    Enzyme and pathway databases

    Reactomei REACT_188202. FCERI mediated Ca+2 mobilization.
    REACT_221970. Ca2+ pathway.

    Miscellaneous databases

    NextBioi 293057.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori B5B2N2.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR015647. NFAT1.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    PANTHERi PTHR12533. PTHR12533. 1 hit.
    PTHR12533:SF5. PTHR12533:SF5. 1 hit.
    Pfami PF00554. RHD. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view ]
    PRINTSi PR01789. NUCFACTORATC.
    SMARTi SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative splicing and expression of human and mouse NFAT genes."
      Vihma H., Pruunsild P., Timmusk T.
      Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB5B2N2_MOUSE
    AccessioniPrimary (citable) accession number: B5B2N2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3