B5AXJ0 (B5AXJ0_ARATH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Heavy metal P-type ATPase EMBL ACF95839.1

Gene names

Name:	HMA5 EMBL ACF95839.1
ORF Names:	At1g63440 EMBL ACF95839.1

Organism

Arabidopsis thaliana (Mouse-ear cress) EMBL ACF95839.1

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	995 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. RuleBase RU000653

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000653
Ligand	ATP-binding RuleBase RU000653 Nucleotide-binding
Molecular function	Hydrolase RuleBase RU000653
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: InterPro copper-transporting ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5AXJ0 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 73CCAAC86D9D1EAF	FASTA	995	108,363
	10 20 30 40 50 60 MATKLLSLTC IRKERFSERY PLVRKHLTRS RDGGGGSSSE TAAFEIDDPI SRAVFQVLGM 70 80 90 100 110 120 TCSACAGSVE KAIKRLPGIH DAVIDALNNR AQILFYPNSV DVETIRETIE DAGFEASLIE 130 140 150 160 170 180 NEANERSRQV CRIRINGMTC TSCSSTIERV LQSVNGVQRA HVALAIEEAE IHYDPRLLSY 190 200 210 220 230 240 DRLLEEIENA GFEAVLISTG EDVSKIDLKI DGELTDESMK VIERSLEALP GVQSVEISHG 250 260 270 280 290 300 TDKISVLYKP DVTGPRNFIQ VIESTVFGHS GHIKATIFSE GGVGRESQKQ GEIKQYYKSF 310 320 330 340 350 360 LWSLVFTVPV FLTAMVFMYI PGIKDLLMFK VINMLTVGEI IRCVLATPVQ FVIGWRFYTG 370 380 390 400 410 420 SYKALRRGSA NMDVLIALGT NAAYFYSLYT VLRAATSPDF KGVDFFETSA MLISFIILGK 430 440 450 460 470 480 YLEVMAKGKT SQAIAKLMNL APDTAILLSL DKEGNVTGEE EIDGRLIQKN DVIKIVPGAK 490 500 510 520 530 540 VASDGYVIWG QSHVNESMIT GEARPVAKRK GDTVIGGTLN ENGVLHVKVT RVGSESALAQ 550 560 570 580 590 600 IVRLVESAQL AKAPVQKLAD RISKFFVPLV IFLSFSTWLA WFLAGKLHWY PESWIPSSMD 610 620 630 640 650 660 SFELALQFGI SVMVIACPCA LGLATPTAVM VGTGVGASQG VLIKGGQALE RAHKVNCIVF 670 680 690 700 710 720 DKTGTLTMGK PVVVKTKLLK NMVLREFYEL VAATEVNSEH PLAKAIVEYA KKFRDDEENP 730 740 750 760 770 780 AWPEACDFVS ITGKGVKATV KGREIMVGNK NLMNDHKVII PDDAEELLAD SEDMAQTGIL 790 800 810 820 830 840 VSINSELIGV LSVSDPLKPS AREAISILKS MNIKSIMVTG DNWGTANSIA REVGIDSVIA 850 860 870 880 890 900 EAKPEQKAEK VKELQAAGHV VAMVGDGIND SPALVAADVG MAIGAGTDIA IEAADIVLMK 910 920 930 940 950 960 SNLEDVITAI DLSRKTFSRI RLNYVWALGY NLMGIPIAAG VLFPGTRFRL PPWIAGAAMA 970 980 990 ASSVSVVCCS LLLKNYKRPK KLDHLEIREI QVERV

References

[1]

"Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the mechanism of copper tolerance variation in Arabidopsis." Kobayashi Y., Kuroda K., Kimura K., Southron-Francis J.L., Furuzawa A., Kimura K., Iuchi S., Kobayashi M., Taylor G.J., Koyama H. Plant Physiol. 148:969-980(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU877769 Genomic DNA. Translation: ACF95839.1. EU877771 Genomic DNA. Translation: ACF95841.1. EU877775 Genomic DNA. Translation: ACF95845.1. EU877780 Genomic DNA. Translation: ACF95850.1. EU877783 Genomic DNA. Translation: ACF95853.1. EU877788 Genomic DNA. Translation: ACF95858.1. EU877794 Genomic DNA. Translation: ACF95864.1.
IPI	IPI00548991.
3D structure databases
ProteinModelPortal	B5AXJ0.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G63440.1-P.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
Genevestigator	B5AXJ0.
Family and domain databases
Gene3D	2.70.150.10. 1 hit. 3.40.1110.10. 1 hit. 3.40.50.1000. 2 hits.
InterPro	IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR008250. ATPase_P-typ_transduc_dom_A. IPR027256. Cation_transp_P-typ_ATPase_IB. IPR001757. Cation_transp_P_typ_ATPase. IPR027183. Cu-transptr_ATPase. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. IPR006122. HMA_Cu_ion-bd. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit. PTHR24093:SF42. PTHR24093:SF42. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 3 hits. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 3 hits.
TIGRFAMs	TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit. TIGR00003. TIGR00003. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B5AXJ0_ARATH

Accession

Primary (citable) accession number: B5AXJ0

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)