B5AK60 (B5AK60_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Multidrug resistance protein 1 Ensembl ENSP00000444095 EMBL ACF94688.1

Gene names

Name:

ABCB1 Ensembl ENSP00000444095

Organism

Homo sapiens (Human) [Reference proteome] EMBL ACF94688.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1216 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. RuleBase RU000684 Contains 2 ABC transmembrane type-1 domains. SAAS SAAS017940

Ontologies

Keywords
Domain	Repeat SAAS SAAS017940
Ligand	ATP-binding RuleBase RU003299 Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5AK60 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 227233F5F2259A8C	FASTA	1,216	134,032
	10 20 30 40 50 60 MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 70 80 90 100 110 120 HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTSDVSKINE 130 140 150 160 170 180 GIGDKIGMFF QSMATFFTGF IVGFTRGWKL TLVILAISPV LGLSAAVWAK ILSSFTDKEL 190 200 210 220 230 240 LAYAKAGAVA EEVLAAIRTV IAFGGQKKEL ERYNKNLEEA KRIGIKKAIT ANISIGAAFL 250 260 270 280 290 300 LIYASYALAF WYGTTLVLSG EYSIGQVLTV FFSVLIGAFS VGQASPSIEA FANARGAAYE 310 320 330 340 350 360 IFKIIDNKPS IDSYSKSGHK PDNIKGNLEF RNVHFSYPSR KEVKILKGLN LKVQSGQTVA 370 380 390 400 410 420 LVGNSGCGKS TTVQLMQRLY DPTEGMVSVD GQDIRTINVR FLREIIGVVS QEPVLFATTI 430 440 450 460 470 480 AENIRYGREN VTMDEIEKAV KEANAYDFIM KLPHKFDTLV GERGAQLSGG QKQRIAIARA 490 500 510 520 530 540 LVRNPKILLL DEATSALDTE SEAVVQVALD KARKGRTTIV IAHRLSTVRN ADVIAGFDDG 550 560 570 580 590 600 VIVEKGNHDE LMKEKGIYFK LVTMQTAGNE VELENAADES KSEIDALEMS SNDSRSSLIR 610 620 630 640 650 660 KRSTRRSVRG SQAQDRKLST KEALDESIPP VSFWRIMKLN LTEWPYFVVG VFCAIINGGL 670 680 690 700 710 720 QPAFAIIFSK IIGVFTRIDD PETKRQNSNL FSLLFLALGI ISFITFFLQG FTFGKAGEIL 730 740 750 760 770 780 TKRLRYMVFR SMLRQDVSWF DDPKNTTGAL TTRLANDAAQ VKGAIGSRLA VITQNIANLG 790 800 810 820 830 840 TGIIISFIYG WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF 850 860 870 880 890 900 RTVVSLTQEQ KFEHMYAQSL QVPYRNSLRK AHIFGITFSF TQAMMYFSYA GCFRFGAYLV 910 920 930 940 950 960 AHKLMSFEDV LLVFSAVVFG AMAVGQVSSF APDYAKAKIS AAHIIMIIEK TPLIDSYSTE 970 980 990 1000 1010 1020 GLMPNTLEGN VTFGEVVFNY PTRPDIPVLQ GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE 1030 1040 1050 1060 1070 1080 RFYDPLAGKV LLDGKEIKRL NVQWLRAHLG IVSQEPILFD CSIAENIAYG DNSRVVSQEE 1090 1100 1110 1120 1130 1140 IVRAAKEANI HAFIESLPNK YSTKVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS 1150 1160 1170 1180 1190 1200 ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VFQNGRVKEH GTHQQLLAQK 1210 GIYFSMVSVQ AGTKRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Cloning of P-glycoprotein cDNA sequence from breast cancer MCF7 cell line." Jiang Y., Sun Q., Xie Z., Liu F., Xu W., Wang Y. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002457 Genomic DNA. No translation available. AC005068 Genomic DNA. No translation available. EU854148 mRNA. Translation: ACF94688.1.
IPI	IPI01009677.
UniGene	Hs.489033. Hs.737655.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000543898; ENSP00000444095; ENSG00000085563.
UCSC	uc011khc.2. human.
Organism-specific databases
HGNC	HGNC:40. ABCB1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG080809.
Gene expression databases
ArrayExpress	B5AK60.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35477809.

Entry information

Entry name

B5AK60_HUMAN

Accession

Primary (citable) accession number: B5AK60

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.