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Protein

Protein quiver

Gene

qvr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K+ channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K+ channel activity and thus reducing neuronal excitability.1 Publication

GO - Molecular functioni

  • GPI anchor binding Source: UniProtKB

GO - Biological processi

  • negative regulation of acetylcholine-gated cation channel activity Source: FlyBase
  • negative regulation of membrane potential Source: FlyBase
  • positive regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  • positive regulation of voltage-gated potassium channel activity Source: InterPro
  • regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
  • regulation of synaptic transmission, cholinergic Source: FlyBase
  • rhythmic process Source: UniProtKB-KW
  • sleep Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Protein quiver
Alternative name(s):
Protein sleepless
Gene namesi
Name:qvr
Synonyms:sss
ORF Names:CG33472
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0260499. qvr.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • external side of plasma membrane Source: FlyBase
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Both daytime and nighttime sleep are severely reduced in both males and females. A small percentage of flies (around 9%) do not sleep at all. A moderate reduction has minimal effects on baseline sleep but markedly reduces the amount of recovery sleep after sleep deprivation. Mutants have impaired Sh-dependent K+ current.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000035976033 – 127Protein quiverAdd BLAST95
PropeptideiPRO_0000359761128 – 158Removed in mature formAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Lipidationi127GPI-anchor amidated asparagine1 Publication1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiB5A5T4.
PRIDEiB5A5T4.

Expressioni

Tissue specificityi

Enriched in brain and head.1 Publication

Gene expression databases

BgeeiFBgn0260499.
ExpressionAtlasiB5A5T4. baseline.
GenevisibleiB5A5T4. DM.

Interactioni

Protein-protein interaction databases

BioGridi77570. 1 interactor.
STRINGi7227.FBpp0113067.

Structurei

3D structure databases

ProteinModelPortaliB5A5T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quiver family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYKW. Eukaryota.
ENOG4111RVN. LUCA.
InParanoidiB5A5T4.
OrthoDBiEOG091G11ZC.
PhylomeDBiB5A5T4.

Family and domain databases

InterProiIPR031424. QVR.
[Graphical view]
PfamiPF17064. QVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5A5T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTQRNAVGN WLLVLTAVIG FLTFIWIPQT SAECQTRSIY CYECDSWTDA
60 70 80 90 100
RCKDPFNYTA LPRDQPPLMT CNGCCVKMVR HQRSPYEVVR RMCTSQLQIN
110 120 130 140 150
LFMVDHVCMM ESSGNGHMCF CEEDMCNSSK NLHTNGCQLH LIPIAVAVSW

LMGQLLSR
Length:158
Mass (Da):18,124
Last modified:September 21, 2011 - v2
Checksum:iBF3E8327EC40A58F
GO

Sequence cautioni

The sequence AAL90233 differs from that shown. Several sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110 – 117MESSGNGH → VEGSGSGR in ACF58241 (PubMed:18635795).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU816195 mRNA. Translation: ACF58241.1.
AE013599 Genomic DNA. Translation: ACL83100.1.
AY089495 mRNA. Translation: AAL90233.1. Sequence problems.
RefSeqiNP_001137646.1. NM_001144174.3.

Genome annotation databases

EnsemblMetazoaiFBtr0114575; FBpp0113067; FBgn0260499.
GeneIDi2768718.
KEGGidme:Dmel_CG33472.
UCSCiCG33472-RA. d. melanogaster.
CG33472-RB. d. melanogaster.

Cross-referencesi

Web resourcesi

Protein Spotlight

Sleepless nights - Issue 101 of January 2009

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU816195 mRNA. Translation: ACF58241.1.
AE013599 Genomic DNA. Translation: ACL83100.1.
AY089495 mRNA. Translation: AAL90233.1. Sequence problems.
RefSeqiNP_001137646.1. NM_001144174.3.

3D structure databases

ProteinModelPortaliB5A5T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi77570. 1 interactor.
STRINGi7227.FBpp0113067.

Proteomic databases

PaxDbiB5A5T4.
PRIDEiB5A5T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0114575; FBpp0113067; FBgn0260499.
GeneIDi2768718.
KEGGidme:Dmel_CG33472.
UCSCiCG33472-RA. d. melanogaster.
CG33472-RB. d. melanogaster.

Organism-specific databases

CTDi2768718.
FlyBaseiFBgn0260499. qvr.

Phylogenomic databases

eggNOGiENOG410IYKW. Eukaryota.
ENOG4111RVN. LUCA.
InParanoidiB5A5T4.
OrthoDBiEOG091G11ZC.
PhylomeDBiB5A5T4.

Miscellaneous databases

ChiTaRSiqvr. fly.
GenomeRNAii2768718.
PROiB5A5T4.

Gene expression databases

BgeeiFBgn0260499.
ExpressionAtlasiB5A5T4. baseline.
GenevisibleiB5A5T4. DM.

Family and domain databases

InterProiIPR031424. QVR.
[Graphical view]
PfamiPF17064. QVR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQVR_DROME
AccessioniPrimary (citable) accession number: B5A5T4
Secondary accession number(s): A1Z8M0, B7YZF3, Q8SXP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.