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B5A5T4

- QVR_DROME

UniProt

B5A5T4 - QVR_DROME

Protein

Protein quiver

Gene

qvr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K+ channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K+ channel activity and thus reducing neuronal excitability.1 Publication

    GO - Molecular functioni

    1. GPI anchor binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of membrane potential Source: FlyBase
    2. positive regulation of circadian sleep/wake cycle, sleep Source: FlyBase
    3. regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
    4. regulation of synaptic transmission, cholinergic Source: FlyBase
    5. sleep Source: FlyBase

    Keywords - Biological processi

    Biological rhythms

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein quiver
    Alternative name(s):
    Protein sleepless
    Gene namesi
    Name:qvr
    Synonyms:sss
    ORF Names:CG33472
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0260499. qvr.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. external side of plasma membrane Source: FlyBase
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Both daytime and nighttime sleep are severely reduced in both males and females. A small percentage of flies (around 9%) do not sleep at all. A moderate reduction has minimal effects on baseline sleep but markedly reduces the amount of recovery sleep after sleep deprivation. Mutants have impaired Sh-dependent K+ current.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 12795Protein quiverPRO_0000359760Add
    BLAST
    Propeptidei128 – 15831Removed in mature formPRO_0000359761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Lipidationi127 – 1271GPI-anchor amidated asparagine1 Publication

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Expressioni

    Tissue specificityi

    Enriched in brain and head.1 Publication

    Gene expression databases

    BgeeiB5A5T4.

    Interactioni

    Protein-protein interaction databases

    BioGridi77570. 1 interaction.
    STRINGi7227.FBpp0113067.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the quiver family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74387.
    InParanoidiB5A5T4.
    OMAiNANRANK.
    OrthoDBiEOG7QC7XG.
    PhylomeDBiB5A5T4.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B5A5T4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWTQRNAVGN WLLVLTAVIG FLTFIWIPQT SAECQTRSIY CYECDSWTDA    50
    RCKDPFNYTA LPRDQPPLMT CNGCCVKMVR HQRSPYEVVR RMCTSQLQIN 100
    LFMVDHVCMM ESSGNGHMCF CEEDMCNSSK NLHTNGCQLH LIPIAVAVSW 150
    LMGQLLSR 158
    Length:158
    Mass (Da):18,124
    Last modified:September 21, 2011 - v2
    Checksum:iBF3E8327EC40A58F
    GO

    Sequence cautioni

    The sequence AAL90233.1 differs from that shown. Reason: Several sequencing errors.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1178MESSGNGH → VEGSGSGR in ACF58241. (PubMed:18635795)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU816195 mRNA. Translation: ACF58241.1.
    AE013599 Genomic DNA. Translation: ACL83100.1.
    AY089495 mRNA. Translation: AAL90233.1. Sequence problems.
    RefSeqiNP_001137646.1. NM_001144174.2.
    UniGeneiDm.20865.

    Genome annotation databases

    EnsemblMetazoaiFBtr0114575; FBpp0113067; FBgn0260499.
    GeneIDi2768718.
    KEGGidme:Dmel_CG33472.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Sleepless nights - Issue 101 of January 2009

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU816195 mRNA. Translation: ACF58241.1 .
    AE013599 Genomic DNA. Translation: ACL83100.1 .
    AY089495 mRNA. Translation: AAL90233.1 . Sequence problems.
    RefSeqi NP_001137646.1. NM_001144174.2.
    UniGenei Dm.20865.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 77570. 1 interaction.
    STRINGi 7227.FBpp0113067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0114575 ; FBpp0113067 ; FBgn0260499 .
    GeneIDi 2768718.
    KEGGi dme:Dmel_CG33472.

    Organism-specific databases

    CTDi 2768718.
    FlyBasei FBgn0260499. qvr.

    Phylogenomic databases

    eggNOGi NOG74387.
    InParanoidi B5A5T4.
    OMAi NANRANK.
    OrthoDBi EOG7QC7XG.
    PhylomeDBi B5A5T4.

    Miscellaneous databases

    ChiTaRSi qvr. drosophila.
    GenomeRNAii 2768718.
    NextBioi 848161.

    Gene expression databases

    Bgeei B5A5T4.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Identification of SLEEPLESS, a sleep-promoting factor."
      Koh K., Joiner W.J., Wu M.N., Yue Z., Smith C.J., Sehgal A.
      Science 321:372-376(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GPI-ANCHOR AT ASN-127, GLYCOSYLATION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.

    Entry informationi

    Entry nameiQVR_DROME
    AccessioniPrimary (citable) accession number: B5A5T4
    Secondary accession number(s): A1Z8M0, B7YZF3, Q8SXP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3