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B5A5T4 (QVR_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein quiver
Alternative name(s):
Protein sleepless
Gene names
Name:qvr
Synonyms:sss
ORF Names:CG33472
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K+ channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K+ channel activity and thus reducing neuronal excitability. Ref.1

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Ref.1.

Tissue specificity

Enriched in brain and head. Ref.1

Post-translational modification

N-glycosylated. Ref.1

Disruption phenotype

Both daytime and nighttime sleep are severely reduced in both males and females. A small percentage of flies (around 9%) do not sleep at all. A moderate reduction has minimal effects on baseline sleep but markedly reduces the amount of recovery sleep after sleep deprivation. Mutants have impaired Sh-dependent K+ current. Ref.1

Sequence similarities

Belongs to the quiver family.

Sequence caution

The sequence AAL90233.1 differs from that shown. Reason: Several sequencing errors.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 12795Protein quiver
PRO_0000359760
Propeptide128 – 15831Removed in mature form
PRO_0000359761

Amino acid modifications

Lipidation1271GPI-anchor amidated asparagine Probable
Glycosylation571N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict110 – 1178MESSGNGH → VEGSGSGR in ACF58241. Ref.1

Sequences

Sequence LengthMass (Da)Tools
B5A5T4 [UniParc].

Last modified September 21, 2011. Version 2.
Checksum: BF3E8327EC40A58F

FASTA15818,124
        10         20         30         40         50         60 
MWTQRNAVGN WLLVLTAVIG FLTFIWIPQT SAECQTRSIY CYECDSWTDA RCKDPFNYTA 

        70         80         90        100        110        120 
LPRDQPPLMT CNGCCVKMVR HQRSPYEVVR RMCTSQLQIN LFMVDHVCMM ESSGNGHMCF 

       130        140        150 
CEEDMCNSSK NLHTNGCQLH LIPIAVAVSW LMGQLLSR 

« Hide

References

« Hide 'large scale' references
[1]"Identification of SLEEPLESS, a sleep-promoting factor."
Koh K., Joiner W.J., Wu M.N., Yue Z., Smith C.J., Sehgal A.
Science 321:372-376(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GPI-ANCHOR, GLYCOSYLATION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Sleepless nights - Issue 101 of January 2009

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU816195 mRNA. Translation: ACF58241.1.
AE013599 Genomic DNA. Translation: ACL83100.1.
AY089495 mRNA. Translation: AAL90233.1. Sequence problems.
RefSeqNP_001137646.1. NM_001144174.2.
UniGeneDm.20865.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid77570. 1 interaction.
STRING7227.FBpp0113067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0114575; FBpp0113067; FBgn0260499.
GeneID2768718.
KEGGdme:Dmel_CG33472.

Organism-specific databases

CTD2768718.
FlyBaseFBgn0260499. qvr.

Phylogenomic databases

eggNOGNOG74387.
InParanoidB5A5T4.
OrthoDBEOG7QC7XG.
PhylomeDBB5A5T4.

Gene expression databases

BgeeB5A5T4.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSqvr. drosophila.
GenomeRNAi2768718.
NextBio848161.

Entry information

Entry nameQVR_DROME
AccessionPrimary (citable) accession number: B5A5T4
Secondary accession number(s): A1Z8M0, B7YZF3, Q8SXP9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 21, 2011
Last modified: April 16, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase