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B5A5T4

- QVR_DROME

UniProt

B5A5T4 - QVR_DROME

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Protein

Protein quiver

Gene

qvr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K+ channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K+ channel activity and thus reducing neuronal excitability.1 Publication

GO - Molecular functioni

  1. GPI anchor binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of membrane potential Source: FlyBase
  2. positive regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  3. regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
  4. regulation of synaptic transmission, cholinergic Source: FlyBase
  5. sleep Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Protein quiver
Alternative name(s):
Protein sleepless
Gene namesi
Name:qvr
Synonyms:sss
ORF Names:CG33472
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0260499. qvr.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. external side of plasma membrane Source: FlyBase
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Both daytime and nighttime sleep are severely reduced in both males and females. A small percentage of flies (around 9%) do not sleep at all. A moderate reduction has minimal effects on baseline sleep but markedly reduces the amount of recovery sleep after sleep deprivation. Mutants have impaired Sh-dependent K+ current.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 12795Protein quiverPRO_0000359760Add
BLAST
Propeptidei128 – 15831Removed in mature formPRO_0000359761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Lipidationi127 – 1271GPI-anchor amidated asparagine1 Publication

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Tissue specificityi

Enriched in brain and head.1 Publication

Gene expression databases

BgeeiB5A5T4.

Interactioni

Protein-protein interaction databases

BioGridi77570. 1 interaction.
STRINGi7227.FBpp0113067.

Family & Domainsi

Sequence similaritiesi

Belongs to the quiver family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74387.
InParanoidiB5A5T4.
OMAiNANRANK.
OrthoDBiEOG7QC7XG.
PhylomeDBiB5A5T4.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5A5T4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWTQRNAVGN WLLVLTAVIG FLTFIWIPQT SAECQTRSIY CYECDSWTDA
60 70 80 90 100
RCKDPFNYTA LPRDQPPLMT CNGCCVKMVR HQRSPYEVVR RMCTSQLQIN
110 120 130 140 150
LFMVDHVCMM ESSGNGHMCF CEEDMCNSSK NLHTNGCQLH LIPIAVAVSW

LMGQLLSR
Length:158
Mass (Da):18,124
Last modified:September 21, 2011 - v2
Checksum:iBF3E8327EC40A58F
GO

Sequence cautioni

The sequence AAL90233.1 differs from that shown. Reason: Several sequencing errors.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1178MESSGNGH → VEGSGSGR in ACF58241. (PubMed:18635795)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU816195 mRNA. Translation: ACF58241.1.
AE013599 Genomic DNA. Translation: ACL83100.1.
AY089495 mRNA. Translation: AAL90233.1. Sequence problems.
RefSeqiNP_001137646.1. NM_001144174.3.

Genome annotation databases

EnsemblMetazoaiFBtr0114575; FBpp0113067; FBgn0260499.
GeneIDi2768718.
KEGGidme:Dmel_CG33472.

Cross-referencesi

Web resourcesi

Protein Spotlight

Sleepless nights - Issue 101 of January 2009

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU816195 mRNA. Translation: ACF58241.1 .
AE013599 Genomic DNA. Translation: ACL83100.1 .
AY089495 mRNA. Translation: AAL90233.1 . Sequence problems.
RefSeqi NP_001137646.1. NM_001144174.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 77570. 1 interaction.
STRINGi 7227.FBpp0113067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0114575 ; FBpp0113067 ; FBgn0260499 .
GeneIDi 2768718.
KEGGi dme:Dmel_CG33472.

Organism-specific databases

CTDi 2768718.
FlyBasei FBgn0260499. qvr.

Phylogenomic databases

eggNOGi NOG74387.
InParanoidi B5A5T4.
OMAi NANRANK.
OrthoDBi EOG7QC7XG.
PhylomeDBi B5A5T4.

Miscellaneous databases

ChiTaRSi qvr. drosophila.
GenomeRNAii 2768718.
NextBioi 848161.

Gene expression databases

Bgeei B5A5T4.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of SLEEPLESS, a sleep-promoting factor."
    Koh K., Joiner W.J., Wu M.N., Yue Z., Smith C.J., Sehgal A.
    Science 321:372-376(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GPI-ANCHOR AT ASN-127, GLYCOSYLATION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiQVR_DROME
AccessioniPrimary (citable) accession number: B5A5T4
Secondary accession number(s): A1Z8M0, B7YZF3, Q8SXP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3