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Protein

Matrix protein 1

Gene

M1

Organism
Influenza A virus (A/mallard/Minnesota/290/1999(H3N2))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.UniRule annotationSAAS annotation
Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.UniRule annotationSAAS annotation

Miscellaneous

Most abundant protein in virion. When expressed alone can form virus-like particles in transfected cells.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix protein 1UniRule annotationSAAS annotation
Short name:
M1UniRule annotation
Gene namesi
Name:M1Imported
Synonyms:MUniRule annotation
OrganismiInfluenza A virus (A/mallard/Minnesota/290/1999(H3N2))Imported
Taxonomic identifieri542900 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

  • Host nucleus UniRule annotationSAAS annotation
  • Virion membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotationSAAS annotation, MembraneUniRule annotationSAAS annotation, Viral matrix proteinUniRule annotationSAAS annotation, Virion

Interactioni

Subunit structurei

Homodimer and homomultimer. Interacts with NEP. Binds ribonucleocapsid by both interacting with genomic RNA and NP protein. May interact with HA and NA. Cannot bind NP without genomic RNA.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB4ZIH4.
SMRiB4ZIH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 252Flu_M1_CInterPro annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 164Membrane-bindingUniRule annotationAdd BLAST164
Regioni165 – 252RNP-bindingUniRule annotationAdd BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi101 – 105Nuclear localization signalUniRule annotation5

Sequence similaritiesi

Belongs to the influenza viruses Matrix protein M1 family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.10.180. 1 hit.
HAMAPiMF_04068. INFV_M1. 1 hit.
InterProiView protein in InterPro
IPR036039. Flu_matrix_M1.
IPR013188. Flu_matrix_M1_C.
IPR001561. Flu_matrix_M1_N.
IPR015799. Flu_matrix_M1_N_sub2.
IPR037533. INFV_M1.
PfamiView protein in Pfam
PF00598. Flu_M1. 1 hit.
PF08289. Flu_M1_C. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD596253. Flu_matrix_M1_C. 1 hit.
PD001061. Flu_matrix_M1_N. 1 hit.
SMARTiView protein in SMART
SM00759. Flu_M1_C. 1 hit.
SUPFAMiSSF48145. SSF48145. 1 hit.

Sequencei

Sequence statusi: Complete.

B4ZIH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLTEVETY VLSIVPSGPL KAEIAQRLED VFAGKNTDLE ALMEWLKTRP
60 70 80 90 100
ILSPLTKGIL GFVFTLTVPS ERGLQRRRFV QNALNGNGDP NNMDKAVKLY
110 120 130 140 150
RKLKREITFH GAKEVALSYS TGALASCMGL IYNRMGTVTT EVAFGLVCAT
160 170 180 190 200
CEQIADSQHR SHRQMVTTTN PLIRHENRMV LASTTAKAME QMAGSSEQAA
210 220 230 240 250
EAMEVASQAR QMVQAMRTIG THPSSSAGLK DDLLENLQAY QKRMGVQMQR

FK
Length:252
Mass (Da):27,882
Last modified:September 23, 2008 - v1
Checksum:i70A8DA1066794A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU743502 Viral cRNA. Translation: ACF25001.1.

Similar proteinsi

Entry informationi

Entry nameiB4ZIH4_9INFA
AccessioniPrimary (citable) accession number: B4ZIH4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 31, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)