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Protein
Submitted name:

Prostate-specific transglutaminase 4

Gene

TGM4

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Cofactori

Note: Binds 1 calcium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei268 – 2681UniRule annotation
Active sitei327 – 3271UniRule annotation
Active sitei350 – 3501UniRule annotation
Metal bindingi390 – 3901CalciumUniRule annotation
Metal bindingi392 – 3921CalciumUniRule annotation
Metal bindingi442 – 4421CalciumUniRule annotation
Metal bindingi447 – 4471CalciumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Prostate-specific transglutaminase 4Imported (EC:2.3.2.13Imported)
Gene namesi
Name:TGM4Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG004342.
KOiK05621.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4YUQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDTSKELQV LHVDFLKQEN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ
60 70 80 90 100
PLQSYHQLKL EFSTGPNPSL AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE
110 120 130 140 150
VTVAVTSTPN AILGEYQLNV KTGNHILKSE ENILYLLFNP WCKEDMVFMP
160 170 180 190 200
DEDERKEYIL NDTGCHYVGA ARSIKYKPWN FGQFEKNVLD CCISLLTESS
210 220 230 240 250
LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG TAPYKWTGSA
260 270 280 290 300
PILQQYYNTK QAVXFGQCWV FAGILTTVLR ALGIPARSVT AFDSAHDTER
310 320 330 340 350
NLTVDTYVNE NGEKITNMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD
360 370 380 390 400
ATPQERSQGV FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM
410 420 430 440 450
VNGQEELHII SMETTSIGKN ISTKAVGQDR RRDITYEYKY SEGSSEERQV
460 470 480 490 500
MDHAFLLLSS EREHRRPVKE NFLHMSVQSD DVLLGNPVNF TVILKRKTAA
510 520 530 540 550
LQNVNISGSF ELQLYTGKKV AKLCDLNKTS QIQGQVSEVT LTLDSKTYIN
560 570 580 590 600
SLAILDDEPV IRGFIIAEIV ESNEIMASEV FXSFQYPEFS IELPNTGRIG
610 620 630 640 650
QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI
660 670 680
KCTPIKTGPK KFIVKLSSKQ VKEINAQKIV LITK
Length:684
Mass (Da):77,266
Last modified:September 22, 2008 - v1
Checksum:i6B897B0EEB17AB82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU685250 Genomic DNA. Translation: ACF75756.1.
RefSeqiNP_001128592.1. NM_001135120.1.
UniGeneiPab.19887.

Genome annotation databases

GeneIDi100189556.
KEGGipon:100189556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU685250 Genomic DNA. Translation: ACF75756.1.
RefSeqiNP_001128592.1. NM_001135120.1.
UniGeneiPab.19887.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100189556.
KEGGipon:100189556.

Organism-specific databases

CTDi7047.

Phylogenomic databases

HOVERGENiHBG004342.
KOiK05621.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Hominoid seminal protein evolution and ancestral mating behavior."
    Carnahan S.J., Jensen-Seaman M.I.
    Am. J. Primatol. 70:939-948(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB4YUQ9_PONAB
AccessioniPrimary (citable) accession number: B4YUQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2008
Last sequence update: September 22, 2008
Last modified: November 25, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.