Reviewed,
UniProtKB/Swiss-Prot B4UT09 (PI4KB_OTOGA)
Last modified
January 19, 2010.
Version 11.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (1) |
 Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphatidylinositol 4-kinase beta Short name=PtdIns 4-kinase beta Short name=PI4K-beta Short name=PI4Kbeta EC=2.7.1.67 | ||||
| Gene names |
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| Organism | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) | ||||
| Taxonomic identifier | 30611 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Strepsirrhini › Lorisiformes › Galagidae › Otolemur |
Protein attributes
| Sequence length | 816 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation By similarity. Involved in Golgi-to-plasma membrane trafficking By similarity. |
| Catalytic activity | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
| Enzyme regulation | Inhibited by wortmannin By similarity. Increased kinase acitvity upon interaction with FREQ/NCS1 By similarity. |
| Subunit structure | Interacts with FREQ/NCS1 in a calcium-independent manner By similarity. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner By similarity. This binding competes with FREQ/NCS1 binding By similarity. Interacts with ARF1 and ARF3 By similarity. |
| Subcellular location | Endomembrane system By similarity. Mitochondrion outer membrane; Peripheral membrane protein By similarity. Rough endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Golgi apparatus By similarity. Note: Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex By similarity. |
| Sequence similarities | Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Contains 1 PI3K/PI4K domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 816 | 816 | Phosphatidylinositol 4-kinase beta | PRO_0000365165 | |||||
Regions | |||||||||
| Domain | 559 – 765 | 207 | PI3K/PI4K | ||||||
Amino acid modifications | |||||||||
| Modified residue | 258 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 263 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 266 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 277 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 280 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 294 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 428 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 438 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 511 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 517 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 519 | 1 | Phosphothreonine By similarity | ||||||
Sequences
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References
| [1] | "NISC comparative sequencing initiative." Antonellis A., Ayele K., Benjamin B., Blakesley R.W., Boakye A., Bouffard G.G., Brinkley C., Brooks S., Chu G., Coleman H., Engle J., Gestole M., Greene A., Guan X., Gupta J., Haghighi P., Han J., Hansen N.  Green E.D.Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | DP000887 Genomic DNA. Translation: ACG76406.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | B4UT09. |
Phylogenomic databases | |
| eggNOG | prNOG12382. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR015433. PI_Kinase. [Graphical view] |
| Gene3D | G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit. |
| PANTHER | PTHR10048. PI_Kinase. 1 hit. |
| Pfam | PF00454. PI3_PI4_kinase. 1 hit. [Graphical view] |
| SMART | SM00146. PI3Kc. 1 hit. [Graphical view] |
| PROSITE | PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PI4KB_OTOGA | ||||||||
| Accession | Primary (citable) accession number: B4UT09 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
