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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation

Cofactori

Ca2+UniRule annotationSAAS annotation

Enzyme regulationi

Inhibited by the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs interfere with the release of progeny virus from infected cells and are effective against all influenza strains. Resistance to neuraminidase inhibitors is quite rare.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateUniRule annotation1
Active sitei135Proton donor/acceptorUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Binding sitei277SubstrateUniRule annotation1
Metal bindingi278Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi282Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi308CalciumUniRule annotation1
Metal bindingi328Calcium; via carbonyl oxygenUniRule annotation1
Binding sitei352SubstrateUniRule annotation1
Active sitei386NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Protein family/group databases

CAZyiGH34 Glycoside Hydrolase Family 34

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
Gene namesi
Name:NAUniRule annotationImported
OrganismiInfluenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))Imported
Taxonomic identifieri381518 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000113251 Componenti: Genome

Subcellular locationi

  • Host apical cell membrane SAAS annotation; Single-pass type II membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 34HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6135

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 401UniRule annotation
Disulfide bondi108 ↔ 113UniRule annotation
Disulfide bondi168 ↔ 215UniRule annotation
Disulfide bondi217 ↔ 222UniRule annotation
Disulfide bondi263 ↔ 276UniRule annotation
Disulfide bondi265 ↔ 274UniRule annotation
Disulfide bondi302 ↔ 319UniRule annotation
Disulfide bondi405 ↔ 430UniRule annotation

Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation, GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 33Involved in apical transport and lipid raft associationUniRule annotationAdd BLAST23
Regioni75 – 453Head of neuraminidaseUniRule annotationAdd BLAST379
Regioni261 – 262Substrate bindingUniRule annotation2

Domaini

Intact N-terminus is essential for virion morphogenesis. Possess two apical sorting signals, one in the ectodomain, which is likely to be a glycan, and the other in the transmembrane domain. The transmembrane domain also plays a role in lipid raft association.UniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd15483 Influenza_NA, 1 hit
HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR033654 Sialidase_Influenza_A/B
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

B4URF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPNQKIITI GSICMVVGII SLILQIGNII SIWISHSIQT GNQNHTGICN
60 70 80 90 100
QGSITYKVVA GQDSTSVILT GNSSLCPIRG WAIHSKDNGI RIGSKGDVFV
110 120 130 140 150
IREPFISCSH LECRTFFLTQ GALLNDKHSR GTFKDRSPYR ALMSCPVGEA
160 170 180 190 200
PSPYNSRFES VAWSASACHD GMGWLTIGIS GPDDGAVAVL KYNGIITETI
210 220 230 240 250
KSWRKNILRT QESECTCVNG SCFTIMTDGP SDGLASYKIF KIEKGKVTKS
260 270 280 290 300
IELNAPNSHY EECSCYPDTG KVMCVCRDNW HGSNRPWVSF DQNLDYKIGY
310 320 330 340 350
ICSGVFGDNP RPKDGTGSCG PVSADGANGV KGFSYKYGNG VWIGRTKSDS
360 370 380 390 400
SRHGFEMIWD PNGWTETDSR FSMRQDVVAM TDRSGYSGSF VQHPELTGLD
410 420 430 440 450
CMRPCFWVEL IRGLPEENAI WTSGSIISFC GVNSDTVDWS WPDGAELPFT

IDK
Length:453
Mass (Da):49,673
Last modified:September 23, 2008 - v1
Checksum:i8064AFE9785A2A1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY034134 Viral cRNA Translation: ACF54601.1

Similar proteinsi

Entry informationi

Entry nameiB4URF0_I33A0
AccessioniPrimary (citable) accession number: B4URF0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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