B4UMQ6 (T23O_ANASK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan 2,3-dioxygenase
Short name=TDO
EC=1.13.11.11

Alternative name(s):
Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Short name=TO
Short name=TRPO
Tryptophan pyrrolase
Tryptophanase

Gene names

Name:	kynA
Ordered Locus Names:	AnaeK_3282

Organism

Anaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]

Taxonomic identifier

447217 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.
Catalytic activity	L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	heme binding Inferred from sequence or structural similarity. Source: UniProtKB tryptophan 2,3-dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Tryptophan 2,3-dioxygenase		PRO_0000360081
Regions
	Region	13 – 17	5	Substrate binding By similarity
	Region	38 – 42	5	Substrate binding By similarity
Sites
	Metal binding	223	1	Iron (heme axial ligand) By similarity
	Binding site	104	1	Substrate By similarity
	Binding site	111	1	Heme By similarity
	Binding site	237	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4UMQ6 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 6F514E92C001B490	FASTA	265	29,397
	10 20 30 40 50 60 MTDPSAHSAA LTYGSYLALD ELLSAQRPRS EEHDELLFIV VHQVYELWFK QVVHELAYLQ 70 80 90 100 110 120 ERLHRGEGGH ALATLKRVLT ILKTVVSQVD VIETMTPRQF TAFRSRLEAA SGFQSAQFRV 130 140 150 160 170 180 LEAMLGRRDE RMLAPYPPGG PGHARIAAAM AAPSLFDSLL RYLATQGFAV PPVPEAPAAG 190 200 210 220 230 240 WRPPSEAVQR VLLDVYRADG EAALVCERFV DLDEGVQEWR YRHVKMVERT IGDKPGTGGS 250 260 AGAQYLRTTL FTPAFPDLWA VRGAL

References

[1]

"Complete sequence of Anaeromyxobacter sp. K." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001131 Genomic DNA. Translation: ACG74502.1.
RefSeq	YP_002135631.1. NC_011145.1.
3D structure databases
ProteinModelPortal	B4UMQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	B4UMQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6786640.
GenomeReviews	Gene locus AnaeK_3282 in contig CP001131_GR.
KEGG	ank:AnaeK_3282.
PATRIC	20941291. VBIAnaSp90767_3326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG647485.
OMA	QYREIEF.
ProtClustDB	CLSK946558.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
KO	K00453.
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23O_ANASK

Accession

Primary (citable) accession number: B4UMQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program