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B4ULG0 (UPPP_ANASK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:AnaeK_0164
OrganismAnaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]
Taxonomic identifier447217 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197346

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B4ULG0 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: D499FF3896CF8A4F

FASTA29230,466
        10         20         30         40         50         60 
MSLVSAALFG LLQALTEFLP VSSTAHLLVF GELLGHSLDD RRFRAFVTII QAGTTLAVLV 

        70         80         90        100        110        120 
YFRADIARLV AASARGLARG RPFGTPEARL GWYIVLGTLP AALAGKLLEH RIEALGNWVI 

       130        140        150        160        170        180 
AGSLVALGLV LLAAERLASH RRRVEDVGAG DALLIGVAQA LALVPGSSRS GTTITGGMLL 

       190        200        210        220        230        240 
GFTREAAARF SFLLSVPITL AAGAYKLWST VPDLRGEAAW TVATVVGTVV SAVAGYLVID 

       250        260        270        280        290 
WLLAWLRTRT TYVFVVWRLA AGAAIAALIL SGVLPAGAEA PPPPPPALHA AP 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. K."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001131 Genomic DNA. Translation: ACG71407.1.
RefSeqYP_002132536.1. NC_011145.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING447217.AnaeK_0164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACG71407; ACG71407; AnaeK_0164.
GeneID6786308.
KEGGank:AnaeK_0164.
PATRIC20934894. VBIAnaSp90767_0167.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMASKTQIMF.
OrthoDBEOG6QP13M.
ProtClustDBCLSK944863.

Enzyme and pathway databases

BioCycASP447217:GHB0-166-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ANASK
AccessionPrimary (citable) accession number: B4ULG0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families