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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciASP447217:G1GCK-164-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:AnaeK_0164
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000001871 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei46 – 66HelicalUniRule annotationAdd BLAST21
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001973461 – 292Undecaprenyl-diphosphataseAdd BLAST292

Proteomic databases

PRIDEiB4ULG0

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit

Sequencei

Sequence statusi: Complete.

B4ULG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVSAALFG LLQALTEFLP VSSTAHLLVF GELLGHSLDD RRFRAFVTII
60 70 80 90 100
QAGTTLAVLV YFRADIARLV AASARGLARG RPFGTPEARL GWYIVLGTLP
110 120 130 140 150
AALAGKLLEH RIEALGNWVI AGSLVALGLV LLAAERLASH RRRVEDVGAG
160 170 180 190 200
DALLIGVAQA LALVPGSSRS GTTITGGMLL GFTREAAARF SFLLSVPITL
210 220 230 240 250
AAGAYKLWST VPDLRGEAAW TVATVVGTVV SAVAGYLVID WLLAWLRTRT
260 270 280 290
TYVFVVWRLA AGAAIAALIL SGVLPAGAEA PPPPPPALHA AP
Length:292
Mass (Da):30,466
Last modified:September 23, 2008 - v1
Checksum:iD499FF3896CF8A4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA Translation: ACG71407.1
RefSeqiWP_012524243.1, NC_011145.1

Genome annotation databases

EnsemblBacteriaiACG71407; ACG71407; AnaeK_0164
KEGGiank:AnaeK_0164

Similar proteinsi

Entry informationi

Entry nameiUPPP_ANASK
AccessioniPrimary (citable) accession number: B4ULG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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