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B4ULG0

- UPPP_ANASK

UniProt

B4ULG0 - UPPP_ANASK

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, AnaeK_0164
Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciASP447217:GHB0-166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:AnaeK_0164
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000001871: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Transmembranei46 – 6621Helical; Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei192 – 21221Helical; Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Transmembranei253 – 27321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Undecaprenyl-diphosphataseUniRule annotation
PRO_1000197346Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_0164.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiMEIGTIF.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4ULG0-1 [UniParc]FASTAAdd to Basket

« Hide

MSLVSAALFG LLQALTEFLP VSSTAHLLVF GELLGHSLDD RRFRAFVTII    50
QAGTTLAVLV YFRADIARLV AASARGLARG RPFGTPEARL GWYIVLGTLP 100
AALAGKLLEH RIEALGNWVI AGSLVALGLV LLAAERLASH RRRVEDVGAG 150
DALLIGVAQA LALVPGSSRS GTTITGGMLL GFTREAAARF SFLLSVPITL 200
AAGAYKLWST VPDLRGEAAW TVATVVGTVV SAVAGYLVID WLLAWLRTRT 250
TYVFVVWRLA AGAAIAALIL SGVLPAGAEA PPPPPPALHA AP 292
Length:292
Mass (Da):30,466
Last modified:September 23, 2008 - v1
Checksum:iD499FF3896CF8A4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG71407.1.
RefSeqiWP_012524243.1. NC_011145.1.
YP_002132536.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG71407; ACG71407; AnaeK_0164.
GeneIDi6786308.
KEGGiank:AnaeK_0164.
PATRICi20934894. VBIAnaSp90767_0167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG71407.1 .
RefSeqi WP_012524243.1. NC_011145.1.
YP_002132536.1. NC_011145.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 447217.AnaeK_0164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG71407 ; ACG71407 ; AnaeK_0164 .
GeneIDi 6786308.
KEGGi ank:AnaeK_0164.
PATRICi 20934894. VBIAnaSp90767_0167.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi MEIGTIF.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci ASP447217:GHB0-166-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiUPPP_ANASK
AccessioniPrimary (citable) accession number: B4ULG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi