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B4UJ61

- PUR9_ANASK

UniProt

B4UJ61 - PUR9_ANASK

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciASP447217:GHB0-1408-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:AnaeK_1391
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001871: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Bifunctional purine biosynthesis protein PurHPRO_1000096039Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_1391.

Structurei

3D structure databases

ProteinModelPortaliB4UJ61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiLKSTLRY.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B4UJ61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRRALVSVS DKTGLVPFAR RLAALGVELL STGGTQKTLA EAGVPVVGVG
60 70 80 90 100
DYTQAPEILG GRVKTLHPRV HGGILYRRGL ASDEADVKAR DIPPIDLVVV
110 120 130 140 150
NLYPFREAVA AGKPFETCVE EIDIGGPTMV RSAAKNSAHV GVVVDPADYE
160 170 180 190 200
KVAAELEATR TLSAATRFYL MKKAFAHTAA YDAAISEYLT AREAPEAAPA
210 220 230 240 250
HFPATLAAVY TKAYDLRYGE NPHQAGAFYR AAREPEEPSV AFADVLQGKE
260 270 280 290 300
LSYNNLLDLQ AALAGVMEFD ETACVIIKHN TPCGVSTGRT AGEAFARARE
310 320 330 340 350
CDPVSAFGGI VALNRPVDEA TASELTSLFL ECVIAPGYDA AARAALAVKK
360 370 380 390 400
NLRLLEAPRL GAARATWRRR PEEGRELRSI PGGLLVMDRD LGSVRRDDCK
410 420 430 440 450
VMTKRAPTEQ EWKDLLFAWK VVKHVKSNAI VFAKDDRTVA IGGGQTSRVE
460 470 480 490 500
SVKTAVMKAA LDVRGSSVGS DAFFPFADGV EEIIKAGATA IIQPGGSMRD
510 520
AEVIAAADKA GIAMVATGMR HFRH
Length:524
Mass (Da):55,969
Last modified:September 23, 2008 - v1
Checksum:i9E4BB6528D87F982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG72622.1.
RefSeqiWP_012525443.1. NC_011145.1.
YP_002133751.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG72622; ACG72622; AnaeK_1391.
GeneIDi6785935.
KEGGiank:AnaeK_1391.
PATRICi20937400. VBIAnaSp90767_1405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG72622.1 .
RefSeqi WP_012525443.1. NC_011145.1.
YP_002133751.1. NC_011145.1.

3D structure databases

ProteinModelPortali B4UJ61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 447217.AnaeK_1391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG72622 ; ACG72622 ; AnaeK_1391 .
GeneIDi 6785935.
KEGGi ank:AnaeK_1391.
PATRICi 20937400. VBIAnaSp90767_1405.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi LKSTLRY.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci ASP447217:GHB0-1408-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiPUR9_ANASK
AccessioniPrimary (citable) accession number: B4UJ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3