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Protein

Probable DNA ligase

Gene

lig

Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATPUniRule annotation
Active sitei215 – 2151N6-AMP-lysine intermediateUniRule annotation
Binding sitei220 – 2201ATPUniRule annotation
Binding sitei235 – 2351ATPUniRule annotation
Binding sitei264 – 2641ATPUniRule annotation
Binding sitei304 – 3041ATPUniRule annotation
Binding sitei376 – 3761ATPUniRule annotation
Binding sitei382 – 3821ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP447217:GHB0-4349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:AnaeK_4290
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001871 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Probable DNA ligasePRO_0000365218Add
BLAST

Proteomic databases

PRIDEiB4UIS1.

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_4290.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4UIS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAELAEVS RAVAATPARL EKVALLSEAL RRLAPDERAV GASWLAGDLA
60 70 80 90 100
GGRVGIGAAT LRAALEAAPP GAAGPGLTVG EVDAALRRIA AAAGPGSGAA
110 120 130 140 150
RRRELDALLA RAGDPERRFL AALVLGELRQ GALEGVLSDA VARVAGLPGA
160 170 180 190 200
EVRRAAMLAG ALPPVAEAAL AEGAAGLARF RLRVGEPVSP MLAQTAAGVD
210 220 230 240 250
EALRALGGEA ALEWKLDGAR IQAHRDGDEV RVFSRSLREV TAAVPEVVAL
260 270 280 290 300
LRAAPEPLLV LDGEAIALRA DGTPEPFQVT MRRFGRKLDV ERLAPDLPLT
310 320 330 340 350
AFFFDALVAG GGELLGAPER ERWAALERAI PAERRVPRLV TGDAAEARAF
360 370 380 390 400
LEEALARGQE GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS
410 420 430 440 450
GRRRGWLSNL HLGARDPATG EFVMLGKTFK GMTDAMLAWQ TERLKALATG
460 470 480 490 500
PLDAWQVPVR PELVVEVAFD GIQASPRYPG GLALRFARVK RYREDKRPED
510
ADTIETVRGL YGG
Length:513
Mass (Da):54,097
Last modified:September 22, 2008 - v1
Checksum:i53187E6F37F04B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG75493.1.
RefSeqiWP_012528245.1. NC_011145.1.
YP_002136622.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG75493; ACG75493; AnaeK_4290.
KEGGiank:AnaeK_4290.
PATRICi20943280. VBIAnaSp90767_4306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG75493.1.
RefSeqiWP_012528245.1. NC_011145.1.
YP_002136622.1. NC_011145.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi447217.AnaeK_4290.

Proteomic databases

PRIDEiB4UIS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG75493; ACG75493; AnaeK_4290.
KEGGiank:AnaeK_4290.
PATRICi20943280. VBIAnaSp90767_4306.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.

Enzyme and pathway databases

BioCyciASP447217:GHB0-4349-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiDNLI_ANASK
AccessioniPrimary (citable) accession number: B4UIS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2009
Last sequence update: September 22, 2008
Last modified: March 31, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.