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B4UIS1 (DNLI_ANASK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:AnaeK_4290
OrganismAnaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]
Taxonomic identifier447217 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365218

Sites

Active site2151N6-AMP-lysine intermediate By similarity
Binding site2131ATP By similarity
Binding site2201ATP By similarity
Binding site2351ATP By similarity
Binding site2641ATP By similarity
Binding site3041ATP By similarity
Binding site3761ATP By similarity
Binding site3821ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B4UIS1 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 53187E6F37F04B77

FASTA51354,097
        10         20         30         40         50         60 
MLLAELAEVS RAVAATPARL EKVALLSEAL RRLAPDERAV GASWLAGDLA GGRVGIGAAT 

        70         80         90        100        110        120 
LRAALEAAPP GAAGPGLTVG EVDAALRRIA AAAGPGSGAA RRRELDALLA RAGDPERRFL 

       130        140        150        160        170        180 
AALVLGELRQ GALEGVLSDA VARVAGLPGA EVRRAAMLAG ALPPVAEAAL AEGAAGLARF 

       190        200        210        220        230        240 
RLRVGEPVSP MLAQTAAGVD EALRALGGEA ALEWKLDGAR IQAHRDGDEV RVFSRSLREV 

       250        260        270        280        290        300 
TAAVPEVVAL LRAAPEPLLV LDGEAIALRA DGTPEPFQVT MRRFGRKLDV ERLAPDLPLT 

       310        320        330        340        350        360 
AFFFDALVAG GGELLGAPER ERWAALERAI PAERRVPRLV TGDAAEARAF LEEALARGQE 

       370        380        390        400        410        420 
GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS GRRRGWLSNL HLGARDPATG 

       430        440        450        460        470        480 
EFVMLGKTFK GMTDAMLAWQ TERLKALATG PLDAWQVPVR PELVVEVAFD GIQASPRYPG 

       490        500        510 
GLALRFARVK RYREDKRPED ADTIETVRGL YGG 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. K."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001131 Genomic DNA. Translation: ACG75493.1.
RefSeqYP_002136622.1. NC_011145.1.

3D structure databases

ProteinModelPortalB4UIS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING447217.AnaeK_4290.

Proteomic databases

PRIDEB4UIS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACG75493; ACG75493; AnaeK_4290.
GeneID6784305.
KEGGank:AnaeK_4290.
PATRIC20943280. VBIAnaSp90767_4306.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAVPIVIPY.
OrthoDBEOG6Q8HXT.

Enzyme and pathway databases

BioCycASP447217:GHB0-4349-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_ANASK
AccessionPrimary (citable) accession number: B4UIS1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families