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B4UIS1

- DNLI_ANASK

UniProt

B4UIS1 - DNLI_ANASK

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Protein
Probable DNA ligase
Gene
lig, AnaeK_4290
Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATP By similarity
Active sitei215 – 2151N6-AMP-lysine intermediate By similarity
Binding sitei220 – 2201ATP By similarity
Binding sitei235 – 2351ATP By similarity
Binding sitei264 – 2641ATP By similarity
Binding sitei304 – 3041ATP By similarity
Binding sitei376 – 3761ATP By similarity
Binding sitei382 – 3821ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP447217:GHB0-4349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:AnaeK_4290
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000001871: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Probable DNA ligaseUniRule annotation
PRO_0000365218Add
BLAST

Proteomic databases

PRIDEiB4UIS1.

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_4290.

Structurei

3D structure databases

ProteinModelPortaliB4UIS1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiVPIVIPY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4UIS1-1 [UniParc]FASTAAdd to Basket

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MLLAELAEVS RAVAATPARL EKVALLSEAL RRLAPDERAV GASWLAGDLA    50
GGRVGIGAAT LRAALEAAPP GAAGPGLTVG EVDAALRRIA AAAGPGSGAA 100
RRRELDALLA RAGDPERRFL AALVLGELRQ GALEGVLSDA VARVAGLPGA 150
EVRRAAMLAG ALPPVAEAAL AEGAAGLARF RLRVGEPVSP MLAQTAAGVD 200
EALRALGGEA ALEWKLDGAR IQAHRDGDEV RVFSRSLREV TAAVPEVVAL 250
LRAAPEPLLV LDGEAIALRA DGTPEPFQVT MRRFGRKLDV ERLAPDLPLT 300
AFFFDALVAG GGELLGAPER ERWAALERAI PAERRVPRLV TGDAAEARAF 350
LEEALARGQE GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS 400
GRRRGWLSNL HLGARDPATG EFVMLGKTFK GMTDAMLAWQ TERLKALATG 450
PLDAWQVPVR PELVVEVAFD GIQASPRYPG GLALRFARVK RYREDKRPED 500
ADTIETVRGL YGG 513
Length:513
Mass (Da):54,097
Last modified:September 23, 2008 - v1
Checksum:i53187E6F37F04B77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG75493.1.
RefSeqiWP_012528245.1. NC_011145.1.
YP_002136622.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG75493; ACG75493; AnaeK_4290.
GeneIDi6784305.
KEGGiank:AnaeK_4290.
PATRICi20943280. VBIAnaSp90767_4306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG75493.1 .
RefSeqi WP_012528245.1. NC_011145.1.
YP_002136622.1. NC_011145.1.

3D structure databases

ProteinModelPortali B4UIS1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 447217.AnaeK_4290.

Proteomic databases

PRIDEi B4UIS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG75493 ; ACG75493 ; AnaeK_4290 .
GeneIDi 6784305.
KEGGi ank:AnaeK_4290.
PATRICi 20943280. VBIAnaSp90767_4306.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi VPIVIPY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci ASP447217:GHB0-4349-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiDNLI_ANASK
AccessioniPrimary (citable) accession number: B4UIS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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