B4UIQ6 (B4UIQ6_ANASK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193 RuleBase RU003812
EC=6.3.1.5 HAMAP MF_00193 RuleBase RU003812

Gene names

Name:	nadE HAMAP MF_00193
Ordered Locus Names:	AnaeK_2865

Organism

Anaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]

Taxonomic identifier

447217 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 RuleBase RU003812 SAAS SAAS003694
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193 SAAS SAAS003694 RuleBase RU004252
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193 RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 NAD SAAS SAAS003694 HAMAP MF_00193 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 EMBL ACG74089.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	38 – 45	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	40	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	B4UIQ6 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 4557690B3EB903D0	FASTA	323	36,115
	10 20 30 40 50 60 MFTRDVLKID APLVSERIEG SIREQVLGTL RRRGAVVGMS GGIDSSVVAS LCVRALGPDR 70 80 90 100 110 120 VVGLLMPERD SSGDALRLGR MLAAHLGIRH VVEDIAPALE GLGCYARQLE AIRMAVPEYG 130 140 150 160 170 180 DGWRCKLTLP SLLEGERLNI TSLTVSDPRG SQRTVRMPPA AYLQMVAATN FKQRTRKMME 190 200 210 220 230 240 YYHADRLNYA VAGTPNRLEY DQGFFVKQGD GAADFKPIAH LYKTQVYALA EHLGVPEEIR 250 260 270 280 290 300 RRPPTTDTFS LAQTQEEFYF ALPYREMDLC LWAHEHDTPA AEVAPVLGLT PEQVERVYRD 310 320 IEAKRRVSRY LHQAPLLVAD PRG

References

[1]

"Complete sequence of Anaeromyxobacter sp. K." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001131 Genomic DNA. Translation: ACG74089.1.
RefSeq	YP_002135218.1. NC_011145.1.
3D structure databases
ProteinModelPortal	B4UIQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	B4UIQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6786323.
GenomeReviews	Gene locus AnaeK_2865 in contig CP001131_GR.
KEGG	ank:AnaeK_2865.
PATRIC	20940425. VBIAnaSp90767_2893.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG351567.
OMA	DGAVDCH.
ProtClustDB	PRK00876.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K01916.
Pfam	PF02540. NAD_synthase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B4UIQ6_ANASK

Accession

Primary (citable) accession number: B4UIQ6

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)