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B4UIN3 (B4UIN3_ANASK) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH2 HAMAP MF_01815
Ordered Locus Names:AnaeK_2842
OrganismAnaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]
Taxonomic identifier447217 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region254 – 2585ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2531 By similarity HAMAP MF_01815
Active site2831 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B4UIN3 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 6D65A486D1104C07

FASTA32635,041
        10         20         30         40         50         60 
MRSLIAGTGS YAPEKVVTNA DLEKLVDTND QWIVERTGIR ERHVVADDQA TSDLALEASR 

        70         80         90        100        110        120 
RALDAAGLDA KDVEMIVVGT VTPDYPFPSV GAVLQGKLGN KKAFAFDVSA ACAGSLYALS 

       130        140        150        160        170        180 
VADRFVASGA VKNALVVGAD ALTRITDWTD RNTCILFGDG AGAMVLKPTD DPQRGIRAVR 

       190        200        210        220        230        240 
LHADGSLVPI LLQPGGGSRD PISEKVVREK SHYVKMNGRE VFKVAVRSLE ESCREVLADE 

       250        260        270        280        290        300 
KLTPGDVTWV IAHQANKRIL DATLHRLEIP ESKCWMNLEK YGNTSAASVP MTLDEANRAG 

       310        320 
WLKPGDTVLM MAIGGGMAWG ASVVRW

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. K."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001131 Genomic DNA. Translation: ACG74066.1.
RefSeqYP_002135195.1. NC_011145.1.

3D structure databases

ProteinModelPortalB4UIN3.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4UIN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6786774.
GenomeReviewsGene locus AnaeK_2842 in contig CP001131_GR.
KEGGank:AnaeK_2842.
PATRIC20940373. VBIAnaSp90767_2868.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAMAKISPE.
ProtClustDBCLSK946392.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB4UIN3_ANASK
AccessionPrimary (citable) accession number: B4UIN3
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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