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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156FADUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciASP447217:GHB0-2830-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:AnaeK_2790
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000001871 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_1000135885Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB4UII2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252054.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiEOG6J74VT.

Family and domain databases

Gene3Di3.50.50.60. 5 hits.
HAMAPiMF_01037. TrmFO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

Sequencei

Sequence statusi: Complete.

B4UII2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDTRVTVIG GGLAGTEAAW QLARAGVAVE LVEMKPERRS PAHVLPGLAE
60 70 80 90 100
LVCSNSLRSD NPLNAVGLLH EELRRLGSLV LGCADETRVP AGDALAVDRE
110 120 130 140 150
RFSEAVTARL TDHAAVRIVH RELEELPPPP ALAVIATGPL TADALAARLA
160 170 180 190 200
ETTGGRLHFY DAIAPIVAAE SIDRSIAYAR SRYGKGSGDD YLNLPLDEAQ
210 220 230 240 250
YHAFVEALLQ GEKVAAHGFE EPRYFEGCLP IEVMAERGLE VLAHGPLKPV
260 270 280 290 300
GLEDPRTGRR PHAVVQLRRE DVDGTAWNLV GFQTRLTWPE QRRIFRAFLP
310 320 330 340 350
GLANAEFVRL GQIHRNTFVD APRVLAPDLS VRAAPHLFLA GQITGVEGYV
360 370 380 390 400
ESAACGLLAA RAVLDRLAGR AFRPPPPATA LGALHRHLTG EAHPPGYDYQ
410 420 430 440 450
PSNVVFALFP PLTGRHRGKA GRKEAHVERA RKELAPWIDT APPTAVPAAP

AAG
Length:453
Mass (Da):48,694
Last modified:September 23, 2008 - v1
Checksum:i2E2AFB08B8A49DE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG74015.1.
RefSeqiWP_012526795.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG74015; ACG74015; AnaeK_2790.
KEGGiank:AnaeK_2790.
PATRICi20940267. VBIAnaSp90767_2815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG74015.1.
RefSeqiWP_012526795.1. NC_011145.1.

3D structure databases

ProteinModelPortaliB4UII2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG74015; ACG74015; AnaeK_2790.
KEGGiank:AnaeK_2790.
PATRICi20940267. VBIAnaSp90767_2815.

Phylogenomic databases

HOGENOMiHOG000252054.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiEOG6J74VT.

Enzyme and pathway databases

BioCyciASP447217:GHB0-2830-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 5 hits.
HAMAPiMF_01037. TrmFO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiTRMFO_ANASK
AccessioniPrimary (citable) accession number: B4UII2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: January 20, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.