B4UHY4 (ARLY_ANASK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	AnaeK_4195

Organism

Anaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]

Taxonomic identifier

447217 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089065

Sequences

	Sequence		Length	Mass (Da)
	B4UHY4 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 0243E6F9931011C7	FASTA	467	50,344
	10 20 30 40 50 60 MRANSKAKPV SRAALAGEAD PRLVALSVSI QDDGALYAED IRGSQAHVSM LAAQGIVPKA 70 80 90 100 110 120 AARRIVAALD QVRAEFAAGK IRFDPALEDV HTHVERRLGE LVGKDAGYLH AGRSRNDQVA 130 140 150 160 170 180 LDERLFIVGA CDRCDAALER LQRAFLGQAR AHERTILPGY THLQRAQPVS LAHHLLAYVE 190 200 210 220 230 240 MFGRDRERFA EVRRRAAISP LGSGALAGTT LPLDREAVAA RLGLAGVTHN SLDAVSDRDS 250 260 270 280 290 300 AAELLFACAL AAVHLSRIGE ELVLWTTKEF GFATLSDAFA TGSSLMPQKK NPDVGELARG 310 320 330 340 350 360 RAGRALGDLV ALLAILKGLP LSYNRDLQED KRPLLGGPEA LVLTADAVAG AVETATFHAA 370 380 390 400 410 420 RMEEALGSGE ALATDAAEYL VDRGVPFREA HEAVGKAAAF SAREGRPMAR LTAAEWATFH 430 440 450 460 RRFEKDVLRC FDARRSLRRR ELPGAPGPRA VRAELRRWEK ALGKARG

References

[1]

"Complete sequence of Anaeromyxobacter sp. K." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001131 Genomic DNA. Translation: ACG75398.1.
RefSeq	YP_002136527.1. NC_011145.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B4UHY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6784210.
GenomeReviews	Gene locus AnaeK_4195 in contig CP001131_GR.
KEGG	ank:AnaeK_4195.
PATRIC	20943084. VBIAnaSp90767_4208.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	MAEDLIF.
ProtClustDB	PRK00855.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ANASK

Accession

Primary (citable) accession number: B4UHY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program