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B4UHR6

- LPXB_ANASK

UniProt

B4UHR6 - LPXB_ANASK

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciASP447217:GHB0-2749-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:AnaeK_2711
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001871: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000191461Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_2711.

Structurei

3D structure databases

ProteinModelPortaliB4UHR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B4UHR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLYSPRLTDQ ILIVAGEASA DLHAARTLHE LQRLRPGITA FGVGGPRLRE
60 70 80 90 100
AGLEALAPAE DISVMGLAEV LPRIPRILGI LRMLGRAAAE RRPRAALLVD
110 120 130 140 150
LPDFNLRLAA RLKKLGIPVV YYVSPTIWAW RQGRAKKIAR VVDRMLCILP
160 170 180 190 200
FEERFYEGTG VSARFVGHPF AERPPPGPAE AYRSALGLPA SRTTIAMVPG
210 220 230 240 250
SRPSELKRLL PPMLQAAERL RAAHPDAQFV VPVAPTLDRA ALEPYLAAHR
260 270 280 290 300
TLEVRLVDGR TEEVVGASDA ALVKSGTSTL EAGLMLRPMV VVYKLSWLSY
310 320 330 340 350
AVARMLVKIA HVALVNILAG RGIVPELLQG DASPERMAAE VEHLLGDRAA
360 370 380
REAQIAALRE VRASLGEPGA PLRVAEEVLG VMR
Length:383
Mass (Da):41,544
Last modified:September 23, 2008 - v1
Checksum:i088F8E2838E85FBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG73936.1.
RefSeqiWP_012526716.1. NC_011145.1.
YP_002135065.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG73936; ACG73936; AnaeK_2711.
GeneIDi6787093.
KEGGiank:AnaeK_2711.
PATRICi20940109. VBIAnaSp90767_2738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001131 Genomic DNA. Translation: ACG73936.1 .
RefSeqi WP_012526716.1. NC_011145.1.
YP_002135065.1. NC_011145.1.

3D structure databases

ProteinModelPortali B4UHR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 447217.AnaeK_2711.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG73936 ; ACG73936 ; AnaeK_2711 .
GeneIDi 6787093.
KEGGi ank:AnaeK_2711.
PATRICi 20940109. VBIAnaSp90767_2738.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci ASP447217:GHB0-2749-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiLPXB_ANASK
AccessioniPrimary (citable) accession number: B4UHR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3