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B4UHR6 (LPXB_ANASK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:AnaeK_2711
OrganismAnaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]
Taxonomic identifier447217 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000191461

Sequences

Sequence LengthMass (Da)Tools
B4UHR6 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 088F8E2838E85FBB

FASTA38341,544
        10         20         30         40         50         60 
MLYSPRLTDQ ILIVAGEASA DLHAARTLHE LQRLRPGITA FGVGGPRLRE AGLEALAPAE 

        70         80         90        100        110        120 
DISVMGLAEV LPRIPRILGI LRMLGRAAAE RRPRAALLVD LPDFNLRLAA RLKKLGIPVV 

       130        140        150        160        170        180 
YYVSPTIWAW RQGRAKKIAR VVDRMLCILP FEERFYEGTG VSARFVGHPF AERPPPGPAE 

       190        200        210        220        230        240 
AYRSALGLPA SRTTIAMVPG SRPSELKRLL PPMLQAAERL RAAHPDAQFV VPVAPTLDRA 

       250        260        270        280        290        300 
ALEPYLAAHR TLEVRLVDGR TEEVVGASDA ALVKSGTSTL EAGLMLRPMV VVYKLSWLSY 

       310        320        330        340        350        360 
AVARMLVKIA HVALVNILAG RGIVPELLQG DASPERMAAE VEHLLGDRAA REAQIAALRE 

       370        380 
VRASLGEPGA PLRVAEEVLG VMR 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. K."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001131 Genomic DNA. Translation: ACG73936.1.
RefSeqYP_002135065.1. NC_011145.1.

3D structure databases

ProteinModelPortalB4UHR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING447217.AnaeK_2711.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACG73936; ACG73936; AnaeK_2711.
GeneID6787093.
KEGGank:AnaeK_2711.
PATRIC20940109. VBIAnaSp90767_2738.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMARRSEIRH.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycASP447217:GHB0-2749-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_ANASK
AccessionPrimary (citable) accession number: B4UHR6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways