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B4UHR6

- LPXB_ANASK

UniProt

B4UHR6 - LPXB_ANASK

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, AnaeK_2711
Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciASP447217:GHB0-2749-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:AnaeK_2711
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000001871: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000191461Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_2711.

Structurei

3D structure databases

ProteinModelPortaliB4UHR6.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B4UHR6-1 [UniParc]FASTAAdd to Basket

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MLYSPRLTDQ ILIVAGEASA DLHAARTLHE LQRLRPGITA FGVGGPRLRE    50
AGLEALAPAE DISVMGLAEV LPRIPRILGI LRMLGRAAAE RRPRAALLVD 100
LPDFNLRLAA RLKKLGIPVV YYVSPTIWAW RQGRAKKIAR VVDRMLCILP 150
FEERFYEGTG VSARFVGHPF AERPPPGPAE AYRSALGLPA SRTTIAMVPG 200
SRPSELKRLL PPMLQAAERL RAAHPDAQFV VPVAPTLDRA ALEPYLAAHR 250
TLEVRLVDGR TEEVVGASDA ALVKSGTSTL EAGLMLRPMV VVYKLSWLSY 300
AVARMLVKIA HVALVNILAG RGIVPELLQG DASPERMAAE VEHLLGDRAA 350
REAQIAALRE VRASLGEPGA PLRVAEEVLG VMR 383
Length:383
Mass (Da):41,544
Last modified:September 23, 2008 - v1
Checksum:i088F8E2838E85FBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG73936.1.
RefSeqiWP_012526716.1. NC_011145.1.
YP_002135065.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG73936; ACG73936; AnaeK_2711.
GeneIDi6787093.
KEGGiank:AnaeK_2711.
PATRICi20940109. VBIAnaSp90767_2738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG73936.1 .
RefSeqi WP_012526716.1. NC_011145.1.
YP_002135065.1. NC_011145.1.

3D structure databases

ProteinModelPortali B4UHR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 447217.AnaeK_2711.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG73936 ; ACG73936 ; AnaeK_2711 .
GeneIDi 6787093.
KEGGi ank:AnaeK_2711.
PATRICi 20940109. VBIAnaSp90767_2738.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci ASP447217:GHB0-2749-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiLPXB_ANASK
AccessioniPrimary (citable) accession number: B4UHR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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