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B4UHG5

- PNP_ANASK

UniProt

B4UHG5 - PNP_ANASK

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi495 – 4951MagnesiumUniRule annotation
    Metal bindingi501 – 5011MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciASP447217:GHB0-1176-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:AnaeK_1167
    OrganismiAnaeromyxobacter sp. (strain K)
    Taxonomic identifieri447217 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000001871: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 721721Polyribonucleotide nucleotidyltransferasePRO_1000147880Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi447217.AnaeK_1167.

    Structurei

    3D structure databases

    ProteinModelPortaliB4UHG5.
    SMRiB4UHG5. Positions 627-701.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini562 – 62160KHUniRule annotationAdd
    BLAST
    Domaini631 – 69969S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiHGNFKSN.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4UHG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPIQKTATV GGKDILLETG KVAKQAHGSV WVRLGDSIVL VTAVSAAEKK    50
    EGIDFFPLTV DYQEKLFAAG RVPGSFFRRE GRPTEKETLT SRLVDRSCRP 100
    LFAEGYSNET QVIATVISFD QENDTDVLAL TGASAALHIS DIPFGGPIAG 150
    VRVARVGGQL VANPTLAQRA EADLDVVMAA SRDAIVMVEG GAQEVSEAVM 200
    IEALLFGQAA VQPLLDAQDA LRAATGNKAR RSFDPPKNDV ELRAKVKALT 250
    WEKVKEAYGR NEKHDRYGRL SEIKKELLQA LKDEAAGDAA KLATIALREK 300
    EIKGYYEDVK YDYMRKMITD ERRRIGGRGM ADIRKITCEV GLLPRVHGSS 350
    LFTRGETQAL VATTLGTAED EQRVEMLTGM VFKKFMLHYN FPPFSVGEVK 400
    FLRSPGRREI GHGALAERAL RAVMPPEDQF PYTVRVVSDI MESNGSSSMA 450
    SVCGGCLSLM DAGVPIKAPV AGIAMGLIKE GEKIAILSDI LGDEDHLGDM 500
    DFKVCGTAAG ITSIQMDIKI GGVTRDILEQ ALAQAAEGRK HILGEMAKAL 550
    SAPRGSISAY APRITTIKIR PERIKDIIGP GGKTIKDITA RTGTSINIED 600
    DGSVSIASPN QDKVEEAIKM IRGLTQEAEV GRIYLGTVRK IAEFGAFVEI 650
    FPGTDGLIHI SELSDKRVKS VSDVLSEGEE VMVKVISVDR SGKIRLSRKE 700
    ALADSAKKSE GTEPPKGEPA K 721
    Length:721
    Mass (Da):77,861
    Last modified:September 23, 2008 - v1
    Checksum:i7AEAFD2AFCDE8E02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001131 Genomic DNA. Translation: ACG72400.1.
    RefSeqiWP_012525225.1. NC_011145.1.
    YP_002133529.1. NC_011145.1.

    Genome annotation databases

    EnsemblBacteriaiACG72400; ACG72400; AnaeK_1167.
    GeneIDi6787778.
    KEGGiank:AnaeK_1167.
    PATRICi20936934. VBIAnaSp90767_1180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001131 Genomic DNA. Translation: ACG72400.1 .
    RefSeqi WP_012525225.1. NC_011145.1.
    YP_002133529.1. NC_011145.1.

    3D structure databases

    ProteinModelPortali B4UHG5.
    SMRi B4UHG5. Positions 627-701.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 447217.AnaeK_1167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG72400 ; ACG72400 ; AnaeK_1167 .
    GeneIDi 6787778.
    KEGGi ank:AnaeK_1167.
    PATRICi 20936934. VBIAnaSp90767_1180.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi HGNFKSN.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci ASP447217:GHB0-1176-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K.

    Entry informationi

    Entry nameiPNP_ANASK
    AccessioniPrimary (citable) accession number: B4UHG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3