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B4UGX9

- PUR5_ANASK

UniProt

B4UGX9 - PUR5_ANASK

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, AnaeK_2608
Organism
Anaeromyxobacter sp. (strain K)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP447217:GHB0-2640-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:AnaeK_2608
OrganismiAnaeromyxobacter sp. (strain K)
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000001871: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000192990Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_2608.

Structurei

3D structure databases

ProteinModelPortaliB4UGX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B4UGX9-1 [UniParc]FASTAAdd to Basket

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MSLTYRDAGV DIDEGDRLVD LIKPHARPTL RPEVLGGIGG FGGLFALDVK    50
KYREPVLVSG TDGVGTKLKV AFAADRHDTV GIDLVAMCVN DIAVVGAEPL 100
FFLDYYATGK LSAEQGAQVV KGIAEGCRQA GCALIGGETA ELPGFYERGE 150
YDLAGFAVGC VDRPRIVDGT RVARGDVVIG IASSGLHSNG FSLARKALLD 200
RYPLDHRFEA LGGRTLADAL LEPTRIYAKD VLALLEQVPV RAFAHITGGG 250
LPGNVPRTLP DGTRAVLEEQ RWPRPVIFDL VEREGQVPRD EMYRTFNMGL 300
GLVAVVAPGD EAAAHAALRA RGLEAWTVGA IEAGGPGEAT CEVVR 345
Length:345
Mass (Da):36,628
Last modified:September 23, 2008 - v1
Checksum:i772132A152D0503F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG73833.1.
RefSeqiWP_012526615.1. NC_011145.1.
YP_002134962.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG73833; ACG73833; AnaeK_2608.
GeneIDi6786917.
KEGGiank:AnaeK_2608.
PATRICi20939887. VBIAnaSp90767_2633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG73833.1 .
RefSeqi WP_012526615.1. NC_011145.1.
YP_002134962.1. NC_011145.1.

3D structure databases

ProteinModelPortali B4UGX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 447217.AnaeK_2608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG73833 ; ACG73833 ; AnaeK_2608 .
GeneIDi 6786917.
KEGGi ank:AnaeK_2608.
PATRICi 20939887. VBIAnaSp90767_2633.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci ASP447217:GHB0-2640-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiPUR5_ANASK
AccessioniPrimary (citable) accession number: B4UGX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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