Reviewed, UniProtKB/Swiss-Prot B4UES2 (MURC_ANASK)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	AnaeK_3828

Organism

Anaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]

Taxonomic identifier

447217 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_1000091076
Regions
	Nucleotide binding	115 – 121	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B4UES2-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 5D2FB63DD6A77FDB	FASTA	458	49,594
	10 20 30 40 50 60 MSLFRSRQAK IHFVGVGGIG MSGIAEVLLN LGYTVSGSDL RESETTRRLA GLGGRISYGH 70 80 90 100 110 120 AAENVLQVDV VVISSAVKRD NPEVLEARRR KIPVIPRAEM LAELMRLKYG VAIAGSHGKT 130 140 150 160 170 180 TTTSMAAHLL AHAGLDPTAV VGGKVNAFGS NAKLGKGDYM VVEADESDGS FLRIPPTIAI 190 200 210 220 230 240 VTNIDPEHLD HWKTPDALRR GFVDFVNRVP FYGLAILCID HPTVQSILPD VEKRAVTYGE 250 260 270 280 290 300 SHQADYRAEA IELSGHAVRF DAFRRDEALG RFEVAMVGRH NALNALAVIA LGDEMGIPPL 310 320 330 340 350 360 VTREALRSFQ GVQRRFTVRG EAAGVTVVDD YGHHPAEVKA TLQGAREAFK RRVVCLFQPH 370 380 390 400 410 420 RYTRTRDLMA EFATAFNDAD VLLLTDIYAA GEEPIPGATA ANLADAIRAW GHRDVTLVPR 430 440 450 AELARAARER VRPGDLVLTL GAGDVTAAGP ELLALLER

References

[1]

"Complete sequence of Anaeromyxobacter sp. K." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001131 Genomic DNA. Translation: ACG75039.1.
RefSeq	YP_002136168.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6785295.
GenomeReviews	Gene locus AnaeK_3828 in contig CP001131_GR.
KEGG	ank:AnaeK_3828.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EWMVVEA.
Family and domain databases
HAMAP	MF_00046. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_ANASK

Accession

Primary (citable) accession number: B4UES2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)