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B4UER8 (MRAY_ANASK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:AnaeK_3824
OrganismAnaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]
Taxonomic identifier447217 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090589

Regions

Transmembrane26 – 4621Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane259 – 27921Helical; Potential
Transmembrane283 – 30321Helical; Potential
Transmembrane311 – 33121Helical; Potential
Transmembrane357 – 37721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B4UER8 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 972FD62179452299

FASTA38041,679
        10         20         30         40         50         60 
MLYHLLYPLA YKLSLLNVLR YPSFRIVAAG LTAMVLGLLL GPIFIERMRV LQYGSTNVRE 

        70         80         90        100        110        120 
DTPDTHKKKA GTPSMGGALI LASVAIATLL FADLANRFVW AALLVTLGYG AIGFTDDWLK 

       130        140        150        160        170        180 
ISKKNSKGLA GKKKLVLQVL VVVVVYYACL TDWRFHVEHR FPWVFVGSYV DLHVTLPFVP 

       190        200        210        220        230        240 
SRLFNPDLGF LYLPFMVFVV IATSNAVNLT DGLDGLAIGP TVVSAMTFLA LSYVAGATIA 

       250        260        270        280        290        300 
GFSLAEYLRV PYIPGAEELG VFCSAIFGAG VAFLWYNTYP ASVFMGDVGS LALGGGLGMM 

       310        320        330        340        350        360 
AVLTKNEFAS AILHGVFLTE TVSVILQVWS FKTTGKRIFR MAPIHHHYEL KGWAEPKIIV 

       370        380 
RFWIISVMLA LVALLSIKLR

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. K."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001131 Genomic DNA. Translation: ACG75035.1.
RefSeqYP_002136164.1. NC_011145.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB4UER8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6785291.
GenomeReviewsGene locus AnaeK_3824 in contig CP001131_GR.
KEGGank:AnaeK_3824.
PATRIC20942407. VBIAnaSp90767_3873.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ANASK
AccessionPrimary (citable) accession number: B4UER8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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