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B4UDQ2 (PYRC_ANASK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase
Short name=DHOase
EC=3.5.2.3
Gene names
Name:pyrC
Ordered Locus Names:AnaeK_2241
OrganismAnaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]
Taxonomic identifier447217 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00220_B

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00220_B

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00220_B

Subunit structure

Homodimer By similarity. HAMAP MF_00220_B

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroorotase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Dihydroorotase HAMAP MF_00220_B
PRO_1000100070

Sites

Metal binding631Zinc 1 By similarity
Metal binding651Zinc 1 By similarity
Metal binding1451Zinc 1; via carbamate group By similarity
Metal binding1451Zinc 2; via carbamate group By similarity
Metal binding1821Zinc 2 By similarity
Metal binding2351Zinc 2 By similarity
Metal binding3101Zinc 1 By similarity

Amino acid modifications

Modified residue1451N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4UDQ2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 42C00A81C4BA77FF

FASTA43345,505
        10         20         30         40         50         60 
MSDVLFIEGG RVIDPASGVD GVRTVVIRDG KVAEVAERVE RPRDARAVDA RNRWVTPGFV 

        70         80         90        100        110        120 
DLHVHLREPG QEYKETVATG ARAAVAGGFT AVCAMPNTKP VNDCAAVTEL VLARAAAAGL 

       130        140        150        160        170        180 
ARVYPVGAIS RGSNGEELAE YGELKASGCV ALSDDGRPVM SSALMRRALE YARAFGLPLT 

       190        200        210        220        230        240 
VHEEDLHLVG KGVMHEGAAA TRLGLKGIPS QAEDVMVLRD IALVELTGGR LHVAHVSTAG 

       250        260        270        280        290        300 
AVRAIREAKR RGLPVTGEVT PHHLALTDDD VGASGYSTDF KMNPPLRSAE DVRACREGLA 

       310        320        330        340        350        360 
DGTLDAIATD HAPHSAVEKD VEFDAAANGI VGLETAFSVC LGLVREGALT ERRLVEALTV 

       370        380        390        400        410        420 
GPARAFGLPA GTLARGAAAD VAVLDAAAEW TVDPARLHSK GRNTPWKGRR LAGRCTHTIV 

       430 
GGRIVHEEGK ADR

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References

[1]"Complete sequence of Anaeromyxobacter sp. K."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001131 Genomic DNA. Translation: ACG73468.1.
RefSeqYP_002134597.1. NC_011145.1.

3D structure databases

ProteinModelPortalB4UDQ2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4UDQ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6784092.
GenomeReviewsGene locus AnaeK_2241 in contig CP001131_GR.
KEGGank:AnaeK_2241.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG724623.
OMASHHQPHE.
ProtClustDBCLSK945757.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRC_ANASK
AccessionPrimary (citable) accession number: B4UDQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: November 16, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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