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B4UDP6

- B4UDP6_ANASK

UniProt

B4UDP6 - B4UDP6_ANASK

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Protein

Isocitrate dehydrogenase [NADP]

Gene

AnaeK_2235

Organism
Anaeromyxobacter sp. (strain K)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciASP447217:GHB0-2259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:AnaeK_2235Imported
OrganismiAnaeromyxobacter sp. (strain K)Imported
Taxonomic identifieri447217 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000001871: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi447217.AnaeK_2235.

Structurei

3D structure databases

ProteinModelPortaliB4UDP6.
SMRiB4UDP6. Positions 12-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRYAIDND.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4UDP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADAKPVVPK DGAKISLVDG KLNVPDRPIL PFIEGDGTGR DIWRASVRVL
60 70 80 90 100
DAAVEKAYRG RRKIAWTEVY AGEKAFTKFN NWLPDETIQA FREYLIGIKG
110 120 130 140 150
PLTTPIGGGI RSLNVALRQL LDLYVCLRPV RWFRGVPSPV KRPEKVNMVI
160 170 180 190 200
FRENTEDIYA GIEWEAGSEQ AKKLLAFLEQ EFPKEYRKIR FPATSGVGVK
210 220 230 240 250
PVSREGTERL VRAALEYAVR ERRRSVTFVH KGNIMKFTEG AFRNWGYALA
260 270 280 290 300
EREFADRVYT WEQWERTKAS RGEEAANAEK QAAVAEGRIL VKDAIADITL
310 320 330 340 350
QQVLTRPEDF DVVATPNLNG DYLSDALAAQ VGGIGIAPGG NANYVTGHAI
360 370 380 390 400
FEATHGTAPK YADLDKVNPG SMILSGEMMF RHLGWNEAAD LIVKGVDGAI
410 420 430
AGHRVTYDFA RLMKAEGVTD AVEVKCSEFG DEIIRHM
Length:437
Mass (Da):48,599
Last modified:September 23, 2008 - v1
Checksum:i782AB6D57DCD2A16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG73462.1.
RefSeqiYP_002134591.1. NC_011145.1.

Genome annotation databases

EnsemblBacteriaiACG73462; ACG73462; AnaeK_2235.
GeneIDi6785211.
KEGGiank:AnaeK_2235.
PATRICi20939115. VBIAnaSp90767_2255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001131 Genomic DNA. Translation: ACG73462.1 .
RefSeqi YP_002134591.1. NC_011145.1.

3D structure databases

ProteinModelPortali B4UDP6.
SMRi B4UDP6. Positions 12-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 447217.AnaeK_2235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG73462 ; ACG73462 ; AnaeK_2235 .
GeneIDi 6785211.
KEGGi ank:AnaeK_2235.
PATRICi 20939115. VBIAnaSp90767_2255.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi RYAIDND.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci ASP447217:GHB0-2259-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KImported.

Entry informationi

Entry nameiB4UDP6_ANASK
AccessioniPrimary (citable) accession number: B4UDP6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3