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B4UDP6

- B4UDP6_ANASK

UniProt

B4UDP6 - B4UDP6_ANASK

Protein

Isocitrate dehydrogenase [NADP]

Gene

AnaeK_2235

Organism
Anaeromyxobacter sp. (strain K)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciASP447217:GHB0-2259-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:AnaeK_2235Imported
    OrganismiAnaeromyxobacter sp. (strain K)Imported
    Taxonomic identifieri447217 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000001871: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi447217.AnaeK_2235.

    Structurei

    3D structure databases

    ProteinModelPortaliB4UDP6.
    SMRiB4UDP6. Positions 12-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiRYAIDND.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4UDP6-1 [UniParc]FASTAAdd to Basket

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    MADAKPVVPK DGAKISLVDG KLNVPDRPIL PFIEGDGTGR DIWRASVRVL    50
    DAAVEKAYRG RRKIAWTEVY AGEKAFTKFN NWLPDETIQA FREYLIGIKG 100
    PLTTPIGGGI RSLNVALRQL LDLYVCLRPV RWFRGVPSPV KRPEKVNMVI 150
    FRENTEDIYA GIEWEAGSEQ AKKLLAFLEQ EFPKEYRKIR FPATSGVGVK 200
    PVSREGTERL VRAALEYAVR ERRRSVTFVH KGNIMKFTEG AFRNWGYALA 250
    EREFADRVYT WEQWERTKAS RGEEAANAEK QAAVAEGRIL VKDAIADITL 300
    QQVLTRPEDF DVVATPNLNG DYLSDALAAQ VGGIGIAPGG NANYVTGHAI 350
    FEATHGTAPK YADLDKVNPG SMILSGEMMF RHLGWNEAAD LIVKGVDGAI 400
    AGHRVTYDFA RLMKAEGVTD AVEVKCSEFG DEIIRHM 437
    Length:437
    Mass (Da):48,599
    Last modified:September 23, 2008 - v1
    Checksum:i782AB6D57DCD2A16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001131 Genomic DNA. Translation: ACG73462.1.
    RefSeqiYP_002134591.1. NC_011145.1.

    Genome annotation databases

    EnsemblBacteriaiACG73462; ACG73462; AnaeK_2235.
    GeneIDi6785211.
    KEGGiank:AnaeK_2235.
    PATRICi20939115. VBIAnaSp90767_2255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001131 Genomic DNA. Translation: ACG73462.1 .
    RefSeqi YP_002134591.1. NC_011145.1.

    3D structure databases

    ProteinModelPortali B4UDP6.
    SMRi B4UDP6. Positions 12-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 447217.AnaeK_2235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG73462 ; ACG73462 ; AnaeK_2235 .
    GeneIDi 6785211.
    KEGGi ank:AnaeK_2235.
    PATRICi 20939115. VBIAnaSp90767_2255.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi RYAIDND.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci ASP447217:GHB0-2259-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KImported.

    Entry informationi

    Entry nameiB4UDP6_ANASK
    AccessioniPrimary (citable) accession number: B4UDP6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3