B4UAM6 (B4UAM6_ANASK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase HAMAP MF_01374
EC=3.1.2.6 HAMAP MF_01374

Alternative name(s):
Glyoxalase II HAMAP MF_01374

Gene names

Name:	gloB HAMAP MF_01374
Ordered Locus Names:	AnaeK_1894

Organism

Anaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]

Taxonomic identifier

447217 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374
Catalytic activity	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374
Subunit structure	Monomer By similarity. HAMAP MF_01374 SAAS SAAS017782
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. HAMAP MF_01374

Ontologies

Keywords
Ligand	Metal-binding HAMAP MF_01374 SAAS SAAS017782 Zinc HAMAP MF_01374 SAAS SAAS017782
Molecular function	Hydrolase HAMAP MF_01374 SAAS SAAS017782 EMBL ACG73122.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	antibiotic catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: InterPro hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	52	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	54	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	56	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	57	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	109	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	126	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	126	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	166	1	Zinc 2 By similarity HAMAP MF_01374

Sequences

	Sequence		Length	Mass (Da)
	B4UAM6 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: E7C4F8FCC9DEBB29	FASTA	255	26,267
	10 20 30 40 50 60 MIFDRRRYGK DNYTYLLAAG GDAALVDPGD PDAALALAAA HGVRPRWILH THGHADHTGG 70 80 90 100 110 120 TAAVARALGA QVLGHGGDAE RFRPDVDLAG RAEVALGALA LRVHPVPGHT PGSVLLEWAG 130 140 150 160 170 180 RLLTGDTLFW AGCGNCRHGG DPARLAESFL GPIARLDGAL EVHPGHDYAA PNLAFALALE 190 200 210 220 230 240 PDGAAARARL AEVEAAHAAG REPAPSTLAG ERAVNPFLRL DAPGVAAAVA RADPAAAAAG 250 PVRRFVALRA LRDRA

References

[1]

"Complete sequence of Anaeromyxobacter sp. K." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001131 Genomic DNA. Translation: ACG73122.1.
RefSeq	YP_002134251.1. NC_011145.1.
3D structure databases
ProteinModelPortal	B4UAM6.
ModBase	Search...
Protein-protein interaction databases
STRING	B4UAM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6784565.
GenomeReviews	Gene locus AnaeK_1894 in contig CP001131_GR.
KEGG	ank:AnaeK_1894.
PATRIC	20938427. VBIAnaSp90767_1916.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG753931.
OMA	RWILHTH.
ProtClustDB	CLSK945962.
Family and domain databases
HAMAP	MF_01374. Glyoxalase_2. [Tree]
InterPro	IPR001279. Beta-lactamas-like. IPR001018. Beta-lactamase_class-B_CS. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
KO	K01069.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
PROSITE	PS00743. BETA_LACTAMASE_B_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4UAM6_ANASK

Accession

Primary (citable) accession number: B4UAM6

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)