Reviewed, UniProtKB/Swiss-Prot B4UA87 (AHPD_ANASK)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	AnaeK_0325

Organism

Anaeromyxobacter sp. (strain K) [Complete proteome] [HAMAP]

Taxonomic identifier

447217 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359470
Sites
	Active site	132	1	Proton donor By similarity
	Active site	135	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	132 ↔ 135		Alternate By similarity
	Disulfide bond	135		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4UA87-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 56EBEADF2FD783C5	FASTA	186	19,420
	10 20 30 40 50 60 MATLDAIREA LPEPARDIKL NLQAVLQPGT LTPAQRWGVA VATAAAARNE RLLAAVLADA 70 80 90 100 110 120 RAEVEPAVVE DALAAAAVMA MNNVYYRFRH MVGKASYAEK PARLRMNRLV KPAASKVDFE 130 140 150 160 170 180 LFALAVSAVN GCETCVRSHE QVVVAGGLSE DQVHEAVRIA AVLHAAAVSL ELAGYAAVPS AAAAAG

References

[1]

"Complete sequence of Anaeromyxobacter sp. K." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G., Beliaev A. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001131 Genomic DNA. Translation: ACG71567.1.
RefSeq	YP_002132696.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6788037.
GenomeReviews	Gene locus AnaeK_0325 in contig CP001131_GR.
KEGG	ank:AnaeK_0325.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAMNNVY.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_ANASK

Accession

Primary (citable) accession number: B4UA87

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)