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B4U9D6 (B4U9D6_HYDS0) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315
Ordered Locus Names:HY04AAS1_1061
OrganismHydrogenobaculum sp. (strain Y04AAS1) [Complete proteome] [HAMAP]
Taxonomic identifier380749 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Hydrogenobaculum

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
B4U9D6 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 5BF6FAEA1CBFB712

FASTA62769,548
        10         20         30         40         50         60 
MSILEHINSV LDLKELSKEE LKLLAEEIRE FIIDVTSKNG GHVAPGLGTV ELTIALLRVF 

        70         80         90        100        110        120 
DVPKDVVVWD IGHQAYPWKI LTDRKEVFHT LRKKGGISGF LRIEESLYDA FGAGHSSTSI 

       130        140        150        160        170        180 
SAAEGFRVAK DLLKDDSYVV AVIGDGAMTA GMVYEALNNI GHLHHNKLII ILNDNEMSIS 

       190        200        210        220        230        240 
KNIGAISTYL NKLITGRHIQ DTRNKIKNIL DKAGFVPRRF AKLTEEFVKG FATPGILFEE 

       250        260        270        280        290        300 
LGLNYIGIID GHNEEALETT LKNAKSIDGP VLIHIVTKKG KGYEPAEENP VKWHGVAPYK 

       310        320        330        340        350        360 
KESGEASKMS GGKSWTQCFS EALLKIAELD ERVVAITPAM KEGSGLVDFA KKYPDRFFDV 

       370        380        390        400        410        420 
GIAEQHAATF SAGLAAGGLK PVLAYYSTFM QRAYDQIIHD IALQNLNVVF AVDRAGLVGE 

       430        440        450        460        470        480 
DGPTHHGVFD ISFLNCIPNI VISSPKDNLE LLDLLYTAIN SNKPFAIRYP RGEAVLSKEE 

       490        500        510        520        530        540 
RAPKLIKIGK WEVLKPGTDI AILTNSYLLK EALEASYELL EHGINIEVVN ARFIKPLDED 

       550        560        570        580        590        600 
MLFDIAKRFN AVLSIEDGVL KGGFGASILE FFNDNMLDVK MYRIGIPDKF VEHASQKELR 

       610        620 
EMFNLTKDGI KKFILEHIVA SQKLENF

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001130 Genomic DNA. Translation: ACG57747.1.
RefSeqYP_002121725.1. NC_011126.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB4U9D6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6743876.
GenomeReviewsGene locus HY04AAS1_1061 in contig CP001130_GR.
KEGGhya:HY04AAS1_1061.
PATRIC22136816. VBIHydSp64203_1068.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG571647.
OMASILEHIN.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4U9D6_HYDS0
AccessionPrimary (citable) accession number: B4U9D6
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info