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B4U950

- PDXA_HYDS0

UniProt

B4U950 - PDXA_HYDS0

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene
pdxA, HY04AAS1_0974
Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291Substrate By similarity
Metal bindingi158 – 1581Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi202 – 2021Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi250 – 2501Divalent metal cation; shared with dimeric partner By similarity
Binding sitei258 – 2581Substrate By similarity
Binding sitei267 – 2671Substrate By similarity
Binding sitei276 – 2761Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

BioCyciHSP380749:GH30-1008-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:HY04AAS1_0974
OrganismiHydrogenobaculum sp. (strain Y04AAS1)
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
ProteomesiUP000001872: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3103104-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotationPRO_1000146489Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi380749.HY04AAS1_0974.

Structurei

3D structure databases

ProteinModelPortaliB4U950.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221591.
KOiK00097.
OMAiWPERPAK.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

B4U950-1 [UniParc]FASTAAdd to Basket

« Hide

MKIFGITMGD PAGIGPELIL KLQKDMEDEN AYVIYGEEYI LKHASSVLGQ    50
NFYYEKVNSV DDVKDKGIYL ISLSLKGALE PSPSSGKLAI AYLARATADA 100
ISKKLNGILT MPINKYFAKA SGFSFNGQTE YLAFADNKKD FAMMMYSDAI 150
KVVLATIHIP LKDIANAINV ELIKQKIKLI KDYIPKYFRF IPTIKVLGLN 200
PHAGEGGLIG DEEAKIIIPA IRDEDVVGPI PPDTAFIDIK KDDIFLCMYH 250
DQGLIPFKML AFDKGSNVTI GLSFLRTSPD HGTAYDIAYK GLARVDSAGY 300
SLELLKRYGY 310
Length:310
Mass (Da):34,242
Last modified:September 23, 2008 - v1
Checksum:i2C1FDF60B25CB139
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG57661.1.
RefSeqiWP_012514017.1. NC_011126.1.
YP_002121639.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG57661; ACG57661; HY04AAS1_0974.
GeneIDi6743786.
KEGGihya:HY04AAS1_0974.
PATRICi22136638. VBIHydSp64203_0982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG57661.1 .
RefSeqi WP_012514017.1. NC_011126.1.
YP_002121639.1. NC_011126.1.

3D structure databases

ProteinModelPortali B4U950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380749.HY04AAS1_0974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG57661 ; ACG57661 ; HY04AAS1_0974 .
GeneIDi 6743786.
KEGGi hya:HY04AAS1_0974.
PATRICi 22136638. VBIHydSp64203_0982.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221591.
KOi K00097.
OMAi WPERPAK.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci HSP380749:GH30-1008-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y04AAS1.

Entry informationi

Entry nameiPDXA_HYDS0
AccessioniPrimary (citable) accession number: B4U950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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