Skip Header

Contribute Send feedback
Read comments (?) or add your own

B4U946 (B4U946_HYDS0) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Nucleoside diphosphate kinase HAMAP-Rule MF_00451
Short name=NDK HAMAP-Rule MF_00451
Short name=NDP kinase HAMAP-Rule MF_00451
EC=2.7.4.6 HAMAP-Rule MF_00451
Alternative name(s):
Nucleoside-2-P kinase HAMAP-Rule MF_00451
Gene names
Name:ndk HAMAP-Rule MF_00451
Ordered Locus Names:HY04AAS1_0970
OrganismHydrogenobaculum sp. (strain Y04AAS1) [Complete proteome] [HAMAP] EMBL ACG57657.1
Taxonomic identifier380749 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Hydrogenobaculum

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity. HAMAP-Rule MF_00451

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP-Rule MF_00451 RuleBase RU004013

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00451

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00451

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00451.

Sequence similarities

Belongs to the NDK family. HAMAP-Rule MF_00451 RuleBase RU004011

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1181Pros-phosphohistidine intermediate By similarity HAMAP-Rule MF_00451
Binding site91ATP By similarity HAMAP-Rule MF_00451
Binding site571ATP By similarity HAMAP-Rule MF_00451
Binding site851ATP By similarity HAMAP-Rule MF_00451
Binding site911ATP By similarity HAMAP-Rule MF_00451
Binding site1051ATP By similarity HAMAP-Rule MF_00451
Binding site1151ATP By similarity HAMAP-Rule MF_00451

Sequences

Sequence LengthMass (Da)Tools
B4U946 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 4C8D3789AAD0D156

FASTA14115,644
        10         20         30         40         50         60 
MERTLVIVKP DAFEKGATGA IIDILSKNGL RLLALKMFKF TKEKAEGFYY VHRERGFFGE 

        70         80         90        100        110        120 
LVEFMCSGPV VAMVLEGENA ISKVRELIGP TDSEEARKIA PNSIRALFGT DKGKNAIHAS 

       130        140 
DSKESASYEI PYIFSSLEIY S

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y04AAS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001130 Genomic DNA. Translation: ACG57657.1.
RefSeqYP_002121635.1. NC_011126.1.

3D structure databases

ProteinModelPortalB4U946.
ModBaseSearch...

Protein-protein interaction databases

STRING380749.HY04AAS1_0970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACG57657; ACG57657; HY04AAS1_0970.
GeneID6743782.
KEGGhya:HY04AAS1_0970.
PATRIC22136630. VBIHydSp64203_0978.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0105.
HOGENOMHOG000224565.
KOK00940.
OMAAEGFYYV.
ProtClustDBCLSK2299764.

Enzyme and pathway databases

BioCycHSP380749:GH30-1004-MONOMER.

Family and domain databases

Gene3D3.30.70.141. 1 hit.
HAMAPMF_00451. NDP_kinase.
InterProIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PANTHERPTHR11349. PTHR11349. 1 hit.
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
SMARTSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMSSF54919. NDK. 1 hit.
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4U946_HYDS0
AccessionPrimary (citable) accession number: B4U946
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info