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B4U8M6

- GSA_HYDS0

UniProt

B4U8M6 - GSA_HYDS0

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciHSP380749:GH30-828-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:HY04AAS1_0800
    OrganismiHydrogenobaculum sp. (strain Y04AAS1)
    Taxonomic identifieri380749 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
    ProteomesiUP000001872: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000121897Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi380749.HY04AAS1_0800.

    Structurei

    3D structure databases

    ProteinModelPortaliB4U8M6.
    SMRiB4U8M6. Positions 3-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4U8M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNKEAFELA KKYMPGGVSS PVRAFKSVGA EPIVVNRGFG AFVEDIEGKK    50
    YIDYMLSFGP LILGHRSEIV VSKIMEALDK GNSFGITNMY EIELSELIIK 100
    ASKVIDKVRF VSSGTEAVMS AIRLARGITN KPYIIKFDGC YHGFSDSVLV 150
    GAGSGVATLG IPGTPGIPKE FAALTIVLDY NDENALEEAF IKYKNQIAAV 200
    LVEPVAGNMG VVLPKESWLK KLRDITKEND ALLIFDEVIT GFRLALGGAA 250
    EYFGIEPDIV CYGKIIGGGM PIGAYGAKNH IMERVAPEGP IYQAGTLSGN 300
    PISVASGLAI LKTLIKDIAI YDRLSELRAY LTYTLSKMLS EKGIPHRINE 350
    IASMFTIFFT DKDVIDFKSA KTSDTALFGK FFRNALKEGV LMPPSQFEAW 400
    FLSTAHTKDV VDTTLEKLKK AIDLL 425
    Length:425
    Mass (Da):46,312
    Last modified:September 23, 2008 - v1
    Checksum:iCF75F55D729E3036
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG57487.1.
    RefSeqiWP_012513843.1. NC_011126.1.
    YP_002121465.1. NC_011126.1.

    Genome annotation databases

    EnsemblBacteriaiACG57487; ACG57487; HY04AAS1_0800.
    GeneIDi6743606.
    KEGGihya:HY04AAS1_0800.
    PATRICi22136276. VBIHydSp64203_0806.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG57487.1 .
    RefSeqi WP_012513843.1. NC_011126.1.
    YP_002121465.1. NC_011126.1.

    3D structure databases

    ProteinModelPortali B4U8M6.
    SMRi B4U8M6. Positions 3-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380749.HY04AAS1_0800.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG57487 ; ACG57487 ; HY04AAS1_0800 .
    GeneIDi 6743606.
    KEGGi hya:HY04AAS1_0800.
    PATRICi 22136276. VBIHydSp64203_0806.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci HSP380749:GH30-828-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y04AAS1.

    Entry informationi

    Entry nameiGSA_HYDS0
    AccessioniPrimary (citable) accession number: B4U8M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3