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B4U896

- SYE_HYDS0

UniProt

B4U896 - SYE_HYDS0

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Protein
Glutamate--tRNA ligase
Gene
gltX, HY04AAS1_0670
Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Zinc By similarity
Metal bindingi98 – 981Zinc By similarity
Metal bindingi123 – 1231Zinc By similarity
Metal bindingi125 – 1251Zinc By similarity
Binding sitei243 – 2431ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
  4. tRNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHSP380749:GH30-692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:HY04AAS1_0670
OrganismiHydrogenobaculum sp. (strain Y04AAS1)
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
ProteomesiUP000001872: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Glutamate--tRNA ligaseUniRule annotation
PRO_0000367690Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi380749.HY04AAS1_0670.

Structurei

3D structure databases

ProteinModelPortaliB4U896.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi8 – 1811"HIGH" regionUniRule annotation
Add
BLAST
Motifi240 – 2445"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiAMGWEVP.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
1.10.8.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020752. aa-tRNA-synth_I_codon-bd_sub1.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4U896-1 [UniParc]FASTAAdd to Basket

« Hide

MVRTRFAPSP TGYMHLGNAR TGIFSYLFAR HHNGTFVLRI EDTDRERSTK    50
EFEDSIIEDL KWLGIEWDEF YRQSERFDIY KEYAKKLIDS GHAYYCFCKE 100
EDIEKQREEA YAQGKAYRYP GTCRHLSKED VEDRLKSGES YVIRFKVPDG 150
QIVSFEDMIR GNISINVDDF GDFVIVRSDG SSVYNFVAVI DDALMKITHV 200
IRGEDHISNT PKQILIYEAL GFKPPEFAHL PVILGEDRTK LSKRHGGVSV 250
RFYKENGYCP EALFNYLCLL GWSSEKVGKE VISKEEAVKY FDIKDINLSP 300
AVFSHDKLYW LNGVYIREIL PEDRLLEDLL SFLEKAYGTV DIEYLKKIVK 350
ATRKEYNTYL EAVEKLRPFF KEKELDEVAK EELSKIDRKV FELLKQEIES 400
LEEITPENLK GVVKNIQKST SLKPKDVWHA LRIALTGSLE GIAIDVIASI 450
LPKEEVLKRL SRYT 464
Length:464
Mass (Da):53,877
Last modified:September 23, 2008 - v1
Checksum:iE320C4BEF14DE1BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG57357.1.
RefSeqiWP_012513713.1. NC_011126.1.
YP_002121335.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG57357; ACG57357; HY04AAS1_0670.
GeneIDi6743470.
KEGGihya:HY04AAS1_0670.
PATRICi22135998. VBIHydSp64203_0673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001130 Genomic DNA. Translation: ACG57357.1 .
RefSeqi WP_012513713.1. NC_011126.1.
YP_002121335.1. NC_011126.1.

3D structure databases

ProteinModelPortali B4U896.
ModBasei Search...

Protein-protein interaction databases

STRINGi 380749.HY04AAS1_0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG57357 ; ACG57357 ; HY04AAS1_0670 .
GeneIDi 6743470.
KEGGi hya:HY04AAS1_0670.
PATRICi 22135998. VBIHydSp64203_0673.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi AMGWEVP.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci HSP380749:GH30-692-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
1.10.8.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020752. aa-tRNA-synth_I_codon-bd_sub1.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y04AAS1.

Entry informationi

Entry nameiSYE_HYDS0
AccessioniPrimary (citable) accession number: B4U896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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