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B4U831

- MDH_HYDS0

UniProt

B4U831 - MDH_HYDS0

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NADUniRule annotation
Binding sitei97 – 971SubstrateUniRule annotation
Binding sitei103 – 1031SubstrateUniRule annotation
Binding sitei110 – 1101NADUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Active sitei190 – 1901Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADUniRule annotation
Nucleotide bindingi133 – 1353NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciHSP380749:GH30-623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:HY04AAS1_0605
OrganismiHydrogenobaculum sp. (strain Y04AAS1)
Taxonomic identifieri380749 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
ProteomesiUP000001872: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Malate dehydrogenasePRO_1000126137Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi380749.HY04AAS1_0605.

Structurei

3D structure databases

ProteinModelPortaliB4U831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

B4U831-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGHKKTVSII GAGNVGEHIA SLLVLKGAVN IRLFDLPKKD GEKLYAHVKG
60 70 80 90 100
KALDMLQMAC ALGIDTDISG FVVDQNGNGY EALEGSDIVV ITAGFPRKPG
110 120 130 140 150
MSRDDLLGIN ISIMNTISEQ IKKYAKNSIV IVVTNPVDIM TYAVYKLLGC
160 170 180 190 200
NRKRVIGMAG VLDSSRFRTF ISLELNVSPK DVHAYVIGGH GDEMVPLAGV
210 220 230 240 250
SNVGGIPIST LIDEKKIKEL VERTRFGGGE IVDYMGTSAY HAPAASVVEM
260 270 280 290 300
IESVALNAKR VLTCSVLLDE EASKYYEAEN LCVGVPVKLG ENGVEKIVKV
310 320 330
PMTDFERDLW MKSVASVKKN IAIADEFVSK YI
Length:332
Mass (Da):35,909
Last modified:September 23, 2008 - v1
Checksum:i0C2FCF9618291C80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG57292.1.
RefSeqiWP_012513648.1. NC_011126.1.
YP_002121270.1. NC_011126.1.

Genome annotation databases

EnsemblBacteriaiACG57292; ACG57292; HY04AAS1_0605.
GeneIDi6743401.
KEGGihya:HY04AAS1_0605.
PATRICi22135862. VBIHydSp64203_0609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001130 Genomic DNA. Translation: ACG57292.1 .
RefSeqi WP_012513648.1. NC_011126.1.
YP_002121270.1. NC_011126.1.

3D structure databases

ProteinModelPortali B4U831.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 380749.HY04AAS1_0605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACG57292 ; ACG57292 ; HY04AAS1_0605 .
GeneIDi 6743401.
KEGGi hya:HY04AAS1_0605.
PATRICi 22135862. VBIHydSp64203_0609.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci HSP380749:GH30-623-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y04AAS1.

Entry informationi

Entry nameiMDH_HYDS0
AccessioniPrimary (citable) accession number: B4U831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3