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B4U831 (MDH_HYDS0) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:HY04AAS1_0605
OrganismHydrogenobaculum sp. (strain Y04AAS1) [Complete proteome] [HAMAP]
Taxonomic identifier380749 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Malate dehydrogenase HAMAP-Rule MF_00487
PRO_1000126137

Regions

Nucleotide binding11 – 166NAD By similarity
Nucleotide binding133 – 1353NAD By similarity

Sites

Active site1901Proton acceptor By similarity
Binding site351NAD By similarity
Binding site971Substrate By similarity
Binding site1031Substrate By similarity
Binding site1101NAD By similarity
Binding site1351Substrate By similarity
Binding site1661Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B4U831 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 0C2FCF9618291C80

FASTA33235,909
        10         20         30         40         50         60 
MGHKKTVSII GAGNVGEHIA SLLVLKGAVN IRLFDLPKKD GEKLYAHVKG KALDMLQMAC 

        70         80         90        100        110        120 
ALGIDTDISG FVVDQNGNGY EALEGSDIVV ITAGFPRKPG MSRDDLLGIN ISIMNTISEQ 

       130        140        150        160        170        180 
IKKYAKNSIV IVVTNPVDIM TYAVYKLLGC NRKRVIGMAG VLDSSRFRTF ISLELNVSPK 

       190        200        210        220        230        240 
DVHAYVIGGH GDEMVPLAGV SNVGGIPIST LIDEKKIKEL VERTRFGGGE IVDYMGTSAY 

       250        260        270        280        290        300 
HAPAASVVEM IESVALNAKR VLTCSVLLDE EASKYYEAEN LCVGVPVKLG ENGVEKIVKV 

       310        320        330 
PMTDFERDLW MKSVASVKKN IAIADEFVSK YI 

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y04AAS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001130 Genomic DNA. Translation: ACG57292.1.
RefSeqYP_002121270.1. NC_011126.1.

3D structure databases

ProteinModelPortalB4U831.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING380749.HY04AAS1_0605.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACG57292; ACG57292; HY04AAS1_0605.
GeneID6743401.
KEGGhya:HY04AAS1_0605.
PATRIC22135862. VBIHydSp64203_0609.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAYGQNDIC.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycHSP380749:GH30-623-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_HYDS0
AccessionPrimary (citable) accession number: B4U831
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families