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B4U831

- MDH_HYDS0

UniProt

B4U831 - MDH_HYDS0

Protein

Malate dehydrogenase

Gene

mdh

Organism
Hydrogenobaculum sp. (strain Y04AAS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351NADUniRule annotation
    Binding sitei97 – 971SubstrateUniRule annotation
    Binding sitei103 – 1031SubstrateUniRule annotation
    Binding sitei110 – 1101NADUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Active sitei190 – 1901Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADUniRule annotation
    Nucleotide bindingi133 – 1353NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciHSP380749:GH30-623-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:HY04AAS1_0605
    OrganismiHydrogenobaculum sp. (strain Y04AAS1)
    Taxonomic identifieri380749 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobaculum
    ProteomesiUP000001872: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Malate dehydrogenasePRO_1000126137Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi380749.HY04AAS1_0605.

    Structurei

    3D structure databases

    ProteinModelPortaliB4U831.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4U831-1 [UniParc]FASTAAdd to Basket

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    MGHKKTVSII GAGNVGEHIA SLLVLKGAVN IRLFDLPKKD GEKLYAHVKG    50
    KALDMLQMAC ALGIDTDISG FVVDQNGNGY EALEGSDIVV ITAGFPRKPG 100
    MSRDDLLGIN ISIMNTISEQ IKKYAKNSIV IVVTNPVDIM TYAVYKLLGC 150
    NRKRVIGMAG VLDSSRFRTF ISLELNVSPK DVHAYVIGGH GDEMVPLAGV 200
    SNVGGIPIST LIDEKKIKEL VERTRFGGGE IVDYMGTSAY HAPAASVVEM 250
    IESVALNAKR VLTCSVLLDE EASKYYEAEN LCVGVPVKLG ENGVEKIVKV 300
    PMTDFERDLW MKSVASVKKN IAIADEFVSK YI 332
    Length:332
    Mass (Da):35,909
    Last modified:September 23, 2008 - v1
    Checksum:i0C2FCF9618291C80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG57292.1.
    RefSeqiWP_012513648.1. NC_011126.1.
    YP_002121270.1. NC_011126.1.

    Genome annotation databases

    EnsemblBacteriaiACG57292; ACG57292; HY04AAS1_0605.
    GeneIDi6743401.
    KEGGihya:HY04AAS1_0605.
    PATRICi22135862. VBIHydSp64203_0609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001130 Genomic DNA. Translation: ACG57292.1 .
    RefSeqi WP_012513648.1. NC_011126.1.
    YP_002121270.1. NC_011126.1.

    3D structure databases

    ProteinModelPortali B4U831.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 380749.HY04AAS1_0605.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACG57292 ; ACG57292 ; HY04AAS1_0605 .
    GeneIDi 6743401.
    KEGGi hya:HY04AAS1_0605.
    PATRICi 22135862. VBIHydSp64203_0609.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci HSP380749:GH30-623-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y04AAS1.

    Entry informationi

    Entry nameiMDH_HYDS0
    AccessioniPrimary (citable) accession number: B4U831
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3